Highly hydrophilic quaternary ammonium salt containing organotin (IV) carboxylate for visualization of antibacterial action and multi-photon absorption activity

Xu, Jing; Wang, Tao; Fang, Zhiyun; Cai, Xiancheng; Dai, Wenxuan; Wang, Jingmin; Tian, Xiaohe; Xü, Xinsheng; Zhang, Qiong; Tian, Yupeng

doi:10.1016/j.dyepig.2022.110186

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…Also, the third mouse, which was injected with a ligand molecule, displayed almost no fluorescence, but in the fourth mouse after being treated with 73 the large intestine displayed strong fluorescence upon one and two-photon fluorescence imaging. 60 …”

Section: Multiphoton Imaging In Anticancer/antibacterial Study Using ...mentioning

confidence: 99%

“…59 Recently, fluorescent tin complexes have been reported for showing two or multiple photon-induced emission characteristics for advanced application in cellular imaging. 28,39,[60][61][62][63][64][65][66][67] The maximum twophoton cross-section reported for tin complexes is in the range of 50-2500 GM (1 GM is 10 À50 cm 4 s photon À1 ; Goe ¨ppert-Mayer units), 60 which is much higher than the commercially used dyes such as DAPI, rhodamine B, and fluorescein. This property of tin(IV) complexes is promising for taking a bright two-photon image without triggering any considerable photodamage to the sample.…”

Section: Tin(iv) Complexes As Bioimaging Probesmentioning

confidence: 99%

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Recent advancements of fluorescent tin(iv) complexes in biomedical molecular imaging

et al. 2023

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Section: Multiphoton Imaging In Anticancer/antibacterial Study Using ...mentioning

confidence: 99%

Section: Tin(iv) Complexes As Bioimaging Probesmentioning

confidence: 99%

Recent advancements of fluorescent tin(iv) complexes in biomedical molecular imaging

et al. 2023

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“…21,22,35−37 Some luminescent organotin(IV) complexes are summarized in Figure 1, which have been used for the study of in vivo imaging and toxicity earlier. 38,39,40,41 On the other hand, the cytotoxicity activity of a metal-based drug can be modulated by the choice of a suitable ligand. For a long time, aroylhydrazone has been paid substantial consideration due to its attractive chemical behavior and biological essentialness.…”

Section: Introductionmentioning

confidence: 99%

“…Some luminescent organotin(IV) complexes are summarized in Figure , which have been used for the study of in vivo imaging and toxicity earlier. ,,, …”

Section: Introductionmentioning

confidence: 99%

Fluorescent Diorganotin(IV) Complexes as Anticancer Agents: Study of Cytotoxicity, Cellular Localization, and Mechanism of Cell Death

et al. 2023

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Three luminescent mixed ligand diorganotin(IV) complexes [Sn2Ph4(L)1–3(DPA)(MeOH)Cl] (where L1 = (Z)-N-((E)-3-ethoxy-2-hydroxybenzylidene)isonicotinohydrazonic acid, L2 = (Z)-N-((E)-5-bromo-2-hydroxybenzylidene)isonicotinohydrazonic acid, L3 = (Z)-N-((E)-2-hydroxy-3-methoxybenzylidene)isonicotinohydrazonic acid, and DPA = dipicolinic acid) (1–3) were synthesized and characterized physiochemically along with the single-crystal X-ray diffraction analysis of 1 and 3. Aqueous phase stabilities of the complexes were performed with UV–vis and 1H nuclear magnetic resonance, suggesting that they are stable in aqueous/biological media. The interaction of 1–3 with DNA was evaluated through analytical methods, which supported the intercalation mode of binding. Also, the interaction of complexes with bovine serum albumin was evaluated with fluorescence quenching experiments showing static quenching. In addition, the results of partition coefficients and cellular uptake suggest that the complexes are hydrophobic and can easily enter the cells. Cytotoxic potential of 1–3 was evaluated against HeLa, HT-29 (cancerous), and NIH-3T3 (normal) cell lines. Complex 2 is the most cytotoxic of the series having IC50 4.2 ± 0.7 μM against HeLa cells. Furthermore, all the complexes showed an apoptotic cell death confirmed by acridine orange/ethidium bromide, cell cycle analysis, and Annexin V-FITC/PI double staining assays. Finally, by using live cell confocal microscopy, it was found that the compounds target the mitochondria of cancer cells and raise the reactive oxygen species level.

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Imine-functionalized organotin(IV) carboxylates: Syntheses, structures and antibacterial activities

Vinayak,

Basu,

Bhowmick

et al. 2024

Inorganica Chimica Acta

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Highly hydrophilic quaternary ammonium salt containing organotin (IV) carboxylate for visualization of antibacterial action and multi-photon absorption activity

Cited by 7 publications

References 35 publications

Recent advancements of fluorescent tin(iv) complexes in biomedical molecular imaging

Recent advancements of fluorescent tin(iv) complexes in biomedical molecular imaging

Fluorescent Diorganotin(IV) Complexes as Anticancer Agents: Study of Cytotoxicity, Cellular Localization, and Mechanism of Cell Death

Imine-functionalized organotin(IV) carboxylates: Syntheses, structures and antibacterial activities

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