Highly Fluorescent Silicon Nanocrystals Stabilized in Water Using Quatsomes

Silbaugh, Dorothy; Ferrer-Tasies, Lidia; Faraudo, Jordi; Veciana, Jaume; Ventosa, Nora; Korgel, Brian A.

doi:10.1021/acs.langmuir.7b03539

Cited by 16 publications

(9 citation statements)

References 37 publications

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“…In our previous work ,, we have been using a slightly different formula. For A 0 , we take the value A 0 ≈ 15 Å 2 , as reported by both experiments and simulations . In the Supporting Information we provide a critical discussion on these values.…”

Section: Discussionmentioning

confidence: 99%

Stability and Free Energy of Nanocrystal Chains and Superlattices

Zha

Travesset

2018

J. Phys. Chem. C

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We discuss the stability and free energy of 1D (chains), 2D (planar superlattices), and 3D (bcc or fcc superlattices) nanocrystals (having hydrocarbons as capping ligands) structures. We start by introducing the method to compute the pressure and free energy. We then analyze the magnitude of many body (or nonadditive) effects, those not described by two body interactions. For 3D superlattices, we examine the relative stability of fcc vs bcc as well as the prevalence of rotator vs crystal phases. We identify a bundling phenomena that occurs during bcc assembly, when next to nearest neighbors begin to make contact. We precisely calculate the density and lattice constant as well as the presence of ligand vortices and find that overall, the simulations fully support the recently introduced Orbifold Topological Model (OTM). By comparing our results with the considerable experimental data available in the literature, we identify a number of subtle effects.

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Section: Discussionmentioning

confidence: 99%

Stability and Free Energy of Nanocrystal Chains and Superlattices

Zha

Travesset

2018

J. Phys. Chem. C

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“…Fluorescence imaging has been broadly applied in the field of bioimaging, as one is able to rapidly diagnose diseases at a relatively low cost . However, its applicability is limited by the fluorescence moiety, which should demonstrate specific site binding efficiency and high fluorescence yield . In this regard, M13 virus‐fluorophore complexes have been developed for fluorescence‐based imaging .…”

Section: Methodsmentioning

confidence: 99%

M13 Virus‐Based Framework for High Fluorescence Enhancement

Huang

deQuilettes

et al. 2019

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Fluorescence imaging is a powerful tool for studying biologically relevant macromolecules, but its applicability is often limited by the fluorescent probe, which must demonstrate both high site‐specificity and emission efficiency. In this regard, M13 virus, a versatile biological scaffold, has previously been used to both assemble fluorophores on its viral capsid with molecular precision and to also target a variety of cells. Although M13‐fluorophore systems are highly selective, these complexes typically suffer from poor molecular detection limits due to low absorption cross‐sections and moderate quantum yields. To overcome these challenges, a coassembly of the M13 virus, cyanine 3 dye, and silver nanoparticles is developed to create a fluorescent tag capable of binding with molecular precision with high emissivity. Enhanced emission of cyanine 3 of up to 24‐fold is achieved by varying nanoparticle size and particle‐fluorophore separation. In addition, it is found that the fluorescence enhancement increases with increasing dye surface density on the viral capsid. Finally, this highly fluorescent probe is applied for in vitro staining of E. coli. These results demonstrate an inexpensive framework for achieving tuned fluorescence enhancements. The methodology developed in this work is potentially amendable to fluorescent detection of a wide range of M13/cell combinations.

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“… 1 , 2 They can be prepared by exploiting sonication or protocols that encompass the use of compressed fluids. 3 As a consequence of their unique characteristics, these nanovesicles have gained increasing attention because they can be employed in a wide variety of applications like biological imaging 4 − 6 and as drug-delivery systems. 3 , 7 In fact, they can integrate small drugs or large biomolecules in the bilayer and/or in the aqueous core and their surface can be decorated with functional groups.…”

Section: Introductionmentioning

confidence: 99%

Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity

Battista

Köber

Bellio

et al. 2022

ACS Appl. Nano Mater.

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The efficacy of the treatment of bacterial infection is seriously reduced because of antibiotic resistance; thus, therapeutic solutions against drug-resistant microbes are necessary. Nanoparticle-based solutions are particularly promising for meeting this challenge because they can offer intrinsic antimicrobial activity and sustained drug release at the target site. Herein, we present a newly developed nanovesicle system of the quatsome family, composed of l -prolinol-derived surfactants and cholesterol, which has noticeable antibacterial activity even on Gram-negative strains, demonstrating great potential for the treatment of bacterial infections. We optimized the vesicle stability and antibacterial activity by tuning the surfactant chain length and headgroup charge (cationic or zwitterionic) and show that these quatsomes can furthermore serve as nanocarriers of pharmaceutical actives, demonstrated here by the encapsulation of (+)-usnic acid, a natural substance with many pharmacological properties.

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Highly Fluorescent Silicon Nanocrystals Stabilized in Water Using Quatsomes

Cited by 16 publications

References 37 publications

Stability and Free Energy of Nanocrystal Chains and Superlattices

Stability and Free Energy of Nanocrystal Chains and Superlattices

M13 Virus‐Based Framework for High Fluorescence Enhancement

Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity

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