Highly enantioselective tandem double Michael reactions catalyzed by Ni(acac)2/(+)-MINBOL complex

β-Chloroaldehydes from Trapping Zirconium Enolates Produced in Asymmetric 1,4-Additions

“…Many ACA/trapping reactions are initiated by organometallic nucleophiles such as Grignard, organoaluminum, and organozinc reagents. The intermediate enolates generated from these ACAs have been trapped in a variety of ways, including with Mander’s reagent, the Heller–Sarpong reagent, carbenium ions, nitro-olefins, and Stork–Jung electrophiles . Trapping of intermediate aluminum enolates has been extensively investigated by Alexakis and co-workers. , Generally, tandem ACA/trapping reactions remain strongly substrate dependent, ,,− and developing new trapping methods would facilitate chemists’ ability to rapidly access complex molecules.…”

“…Many ACA/trapping reactions are initiated by organometallic nucleophiles such as Grignard, organoaluminum, and organozinc reagents. The intermediate enolates generated from these ACAs have been trapped in a variety of ways, 1 including with Mander's reagent, 3 the Heller−Sarpong reagent, 4 carbenium ions, 5 nitro-olefins, 6 and Stork−Jung electrophiles. 7 Trapping of intermediate aluminum enolates has been extensively investigated by Alexakis and co-workers.…”