We developed herein an iridium-catalyzed direct CÀ H activation/ CÀ N bond formation reaction of benzenesulfonamides with sulfonyl azides. The amidation reaction provides a protocol for the synthesis of 2-aminobenzesulfonamides in good to excellent yields. This strategy features a wide substrate scope, tolerates a broad range of functional groups under external oxidant-free conditions and only releases molecular nitrogen as the sole by-product. Moreover, the preliminary mechanism was investigated and the proposed reaction pathway was provided. Figure 1. Selected biologically active benzothidiazine-1,1-dioxides containing the 2-aminobenzenesulfonamides motif.