Highly Elastic and Moldable Polyester Biomaterial for Cardiac Tissue Engineering Applications

Huyer, Locke Davenport; Zhang, Boyang; Korolj, Anastasia; Montgomery, Miles; Drecun, Stasja; Conant, Genevieve; Zhao, Yong; Reis, Lewis A.

doi:10.1021/acsbiomaterials.5b00525

Cited by 83 publications

(101 citation statements)

References 32 publications

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“…Both materials were initially developed for tissue engineering applications inside the body. PGS is approved by the US Food and Drug Administration (FDA) for biomedical use, while POMaC has been subject to extensive biocompatibility studies, demonstrating its cell and tissue biocompatibility comparable to PLLA control 19,20 . In addition to their established biocompatibility upon degradation, they are excellent candidates for this application in terms of their mechanical properties and the degradation characteristics, which can be tuned by varying the polymerization conditions 17,18 .…”

Section: Biodegradable Sensor Concept and Fabricationmentioning

confidence: 99%

A stretchable and biodegradable strain and pressure sensor for orthopaedic application

et al. 2018

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The ability to monitor, in real time, the mechanical forces on tendons after surgical repair could allow personalised rehabilitation programs to be developed for recovering patients. However, the development of devices capable of such measurements has been hindered by the strict requirements of biocompatible materials and the need for sensors with satisfactory performance. Here we report an implantable pressure and strain sensor made entirely of biodegradable materials. The sensor is designed to degrade after its useful lifetime, eliminating the need for a second surgery to remove the device. It can measure strain and pressure independently using two vertically isolated sensors capable of discriminating strain as small as 0.4% and the pressure exerted by a grain of salt (12 Pa) without interfering with one another. The device has minimal hysteresis, a response time in the millisecond range, and an excellent cycling stability for strain and pressure sensing, respectively. We have incorporated a biodegradable elastomer which was optimized to improve the strain cycling performances by 54%. An in vivo study shows that the sensor exhibits excellent biocompatibility and function in a rat model, illustrating the potential applicability of the device to the real-time monitoring of tendon healing. Text body In the U.S. alone, around 14 million people per year suffer from tendon, ligament, and joint injuries 1. After injury, tissues in the body undergo changes in their native biomechanical properties in order to repairs themselves. This is true for both hard tissues (bones) and soft tissues (tendons, skin, muscles). The objective of surgery and rehabilitation is to restore the tissues to their pre-injury function, with biomechanical properties as close as possible to native properties 2. A diagnostic tool that measures the biomechanical properties of the repair site in real-time would represent a significant step towards improved assessment of healing and the development of personalized rehabilitation strategies 3. Current clinical practice for monitoring tissue rehabilitation includes magnetic resonance imaging (MRI) or ultrasound, which provide a snapshot of tissue density and inflammation 4. Implantable sensors could give continuous information about tissue strain during rehabilitation protocols, as well as during the patient's daily activities, allowing activities to be tailored based on what the tissue can tolerate. Previously described implantable sensors have limited biocompatibility or have been designed for laboratory biomechanics studies rather than clinical practice 4,5 .

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Section: Biodegradable Sensor Concept and Fabricationmentioning

confidence: 99%

A stretchable and biodegradable strain and pressure sensor for orthopaedic application

et al. 2018

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“…The obtained mold can then be capped with a glass slide or a second PDMS block through plasma oxidation methods or through pressure application to form noncovalent bonds . PDMS prototypes in this phase can both serve as on chip devices, or support further fabrication by serving as a mold for a secondary material type . Microchannel cross‐sections of straight lines and rectangles, are easy to fabricate but they have little resemblance to complicated branching structures in the body that involve tortuous microchannels with a round cross‐section .…”

Section: Materials In Organ‐on‐a‐chip Platformsmentioning

confidence: 99%

“…Common polyesters include PLA, poly(lactic acid‐ co ‐glycolic acid) (PLGA), polyglycolic acid, poly(1,8‐octanediol citrate), and poly(glycerol sebacate) . We have recently used polyesters in OOC technology including poly(octamethylene maleate (anhydride) citrate) (POMAC), and poly(octamethylene maleate (anhydride) 1,2,4‐butanetricarboxylate) (124 polymer) . These materials are moldable and elastic, and demonstrated utility in developing a biodegradable microvascularized scaffolds for OOC constructs (Figure E) …”

Section: Materials In Organ‐on‐a‐chip Platformsmentioning

confidence: 99%

Organ‐On‐A‐Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

Ahadian

Civitarese

Bannerman

et al. 2017

Adv Healthcare Materials

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243

162

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Significant advances in biomaterials, stem cell biology, and microscale technologies have enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs, referred to as organ-on-a-chip (OOC) platforms, have emerged as a powerful tool in tissue analysis and disease modeling for biological and pharmacological applications. A variety of biomaterials are used in tissue fabrication providing multiple biological, structural, and mechanical cues in the regulation of cell behavior and tissue morphogenesis. Cells derived from humans enable the fabrication of personalized OOC platforms. Microscale technologies are specifically helpful in providing physiological microenvironments for tissues and organs. In this review, biomaterials, cells, and microscale technologies are described as essential components to construct OOC platforms. The latest developments in OOC platforms (e.g., liver, skeletal muscle, cardiac, cancer, lung, skin, bone, and brain) are then discussed as functional tools in simulating human physiology and metabolism. Future perspectives and major challenges in the development of OOC platforms toward accelerating clinical studies of drug discovery are finally highlighted.

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“…The core capability of our integrated vasculature for assessing dynamic events (InVADE) platform originates from the convergence of microfabricated scaffolds with standard cell‐culture plate. The base material for the scaffolds was constructed with a synthetic highly elastic polymer, poly(octamethylene maleate (anhydride) 1,2,4‐butanetricarboxylate) (here referred to as 1,2,4 polymer) . 1,2,4 polymer is amendable to both ultraviolet (UV) and heat polymerization.…”

Section: Resultsmentioning

confidence: 99%

InVADE: Integrated Vasculature for Assessing Dynamic Events

Lai

Huyer

et al. 2017

Adv Funct Materials

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100

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Drug screening with simplified 2D cell culture and relevant animal testing fail to predict clinical outcomes. With the rising cost of drug development, predictive 3D tissue models with human cells are in urgent demand. Establishing vascular perfusion of 3D tissues has always been a challenge, but it is necessary to mimic drug transport and to capture complex interorgan crosstalk. Here, a versatile multiwell plate is presented empowered by built-in microfabricated vascular scaffolds that define the vascular space and support self-assembly of various parenchymal tissues. In this configuration, assembly and organ-specific function of a metabolically active liver, a free-contracting cardiac muscle, and a metastatic solid tumor are demonstrated, tracking organ function using noninvasive analysis techniques. By linking the 3D tumor and the liver tissue in series, it is demonstrated that the presence of liver tissue is crucial to correctly reveal the efficacy of a chemotherapeutic drug, Tegafur. Furthermore, the complete cancer metastasis cascade is demonstrated across multiple organs, where cancer cells escaping from the solid tumor can invade a distant liver tissue connected through a continuous vascular interface. This combinatory use of microfabricated scaffold onto a standard cell culturing platform can offer important insights into the mechanics of complex interorgan biological events.

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Highly Elastic and Moldable Polyester Biomaterial for Cardiac Tissue Engineering Applications

Cited by 83 publications

References 32 publications

A stretchable and biodegradable strain and pressure sensor for orthopaedic application

A stretchable and biodegradable strain and pressure sensor for orthopaedic application

Organ‐On‐A‐Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

InVADE: Integrated Vasculature for Assessing Dynamic Events

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