Highly Efficient Stereoconservative Amidation and Deamination of α‐Amino Acids.

Abstract

Acids. -A highly efficient and stereoselective protection/deprotection and amidation/ deamidation protocol for chiral α-amino acids is presented. It leads to important building blocks for synthetic peptides. -(SHENDAGE, D. M.; FROEHLICH, R.; HAUFE*, G.; Org. Lett. 6 (2004) 21, 3675-3678; Org.-Chem. Inst., Westfael. Wilhelms Univ., D-48149 Muenster, Germany; Eng.) -Steudel 05-180

Synthesis and spectral characteristics of fluorescent dyes based on coumarin fluorophore and hindered amine stabilizer in solution and polymer matrices

“…The protection and deprotection of the amino group was performed according to the method described in Ref. [36] by di-tertbutyldicarbonate (Boc 2 O) and hydrolysis with tri-fluoro-acetic acid (CF 3 COOH).…”

Synthesis of Estrone-Opioid Peptide Analogue With Expected Analgesic Activity

“…The peptide was then filtered, dried, and recrystallized from ethyl acetate-ether (23) . Yield percent, physical appearance, melting point, R f value, and IR interpretation werelisted in Table (2).…”

“…The solvents were removed under reduced pressure leaving a sticky product which after triturated several times with diethel ether a solid material obtained and was recrystallized from methanol-diethyl ether (3-1) (23) . Yield percent, physical appearance, melting point, R f value, and IR interpretation werelisted in Table (2).…”