Highly efficient magnetically separable Zn-Ag@l-arginine Fe3O4 catalyst for synthesis of 2-aryl-substituted benzimidazoles and multicomponent synthesis of pyrimidines

Kulkarni, Padmakar A.; Kahandal, Sandeep S.; Mirgane, Nitin A.; Satpati, Ashis Kumar; Shendage, Suresh S.

doi:10.1016/j.rechem.2022.100655

Cited by 5 publications

(2 citation statements)

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“…[23][24][25][26] Imidazole derivatives are a valuable class of nitrogen-containing heterocycles, whose synthesis and activities are always an attractive challenge among synthetic chemists. [27][28][29] Ketoconazole, miconazole and clotrimazole are imidazole derivatives and are widely used in the treatment of fungal infections. [30][31][32] Molecules containing imidazole ring are used to treat duodenal and gastric ulcers, gastroesophageal reflux disease, and associated symptoms such as heartburn and pain.…”

Section: Introductionmentioning

confidence: 99%

“…Heterocyclic compounds in particular nitrogen heterocycles are abundantly seen in the structure of various medicinal compounds for veterinary and herbal medicine [23–26] . Imidazole derivatives are a valuable class of nitrogen–containing heterocycles, whose synthesis and activities are always an attractive challenge among synthetic chemists [27–29] . Ketoconazole, miconazole and clotrimazole are imidazole derivatives and are widely used in the treatment of fungal infections [30–32] .…”

Section: Introductionmentioning

confidence: 99%

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One–Pot Three–Component Synthesis of 2,4,5–Triaryl Imidazoles using Fe3O4@BisImid−CuBr Nanocomposite as an Ecofriendly and Efficient Magnetically Reusable Catalyst

Al‐Dolaimy,

Alsalamy,

Abdullah Abbas

et al. 2024

ChemistrySelect

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Imidazoles are one of the keys of N‐heterocycle molecules that exist in the structure of many biomolecules. In this research project, we reported that Fe3O4@BisImid−CuBr nanocomposite is an attractive and efficient nanomagnetic catalyst to afford 2,4,5–triaryl imidazoles through reactions of 1,2–diketones and aldehydes in the presence of NH4OAc under ecofriendly conditions. The Fe3O4@BisImid−CuBr nanocomposite was readily fabricated by a simple method from available reagents and its structure was analyzed by spectroscopic techniques. SEM and TEM images affirmed the formation of particles in spherical shape and nanometer–size. Under this methodology, a diverse library of triaryl imidazoles were afforded with high yields in water. This synthetic methodology has significant features such as (a) high yields and high purity of the products (b) suitable reaction time (c) use of magnetic reusable nanocatalyst (d) high reusability of Fe3O4@BisImid−CuBr nanocatalyst and the performance of reactions in aqueous medium.

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