Highly efficient H₂S scavengersviathiolysis of positively-charged NBD amines

Abstract

<p>H2S is a well-known toxic gas and also a gaseous signaling molecule involved in many biological processes. Advanced chemical tools that can regulate H2S levels in vivo are useful for...</p>

An NBD tertiary amine is a fluorescent quencher and/or a weak green-light fluorophore in H2S-specific probes

“…According to the above studies and previous works on NBD-based probes, 7 c ,20–25 we summarize that the NBD tertiary amine can be a green-light fluorophore and/or fluorescent quencher in different cases (Scheme 3). Four types of cases are highlighted below.…”

Chemiluminescence Detection of Hydrogen Sulfide Release by β-Lactamase-Catalyzed β-Lactam Biodegradation: Unprecedented Pathway for Monitoring β-Lactam Antibiotic Bacterial Resistance

“…Hydrogen sulfide is an important biological signaling molecule that recently is gaining considerable scientific attention. − Therefore, numerous probes, including a chemiluminescent one, for detection of hydrogen sulfide were developed in order to better understand the chemistry and properties of this signaling molecule in biological systems. ,,, However, hydrogen sulfide was never linked to β-lactamase activity and never considered as a biodegradation marker for antibiotic bacterial resistance.…”

Fluorescent probes based on nucleophilic aromatic substitution reactions for reactive sulfur and selenium species: Recent progress, applications, and design strategies

“…Probes that use NBD as a reactive group can be mainly classified into those with an NBD-O ether, an NBD-S ether, or an NBD-N bond [111] , [192] , [193] , [194] , [195] , [196] . When forming the above structures, NBD will show different fluorescence emissions, making it suitable to distinguish different RSSs [197] , [198] , [199] , [200] , [201] , [202] , [203] , [204] .…”