Highly Efficient Fluorescent Material Based on Rare-Earth-Modified Polyhydroxyalkanoates

Abstract

Fluorescent materials play an important role in biomedical fields. However, the main types of fluorescent materials suffer from several disadvantages especially the biotoxicity, which largely restrict its wider applications in biological fields. In this study, a highly efficient rare-earthmodified fluorescent material was successfully designed and fabricated based on polyhydroxyalkanoates, which are known as biodegradable and biocompatible materials. A new Functional-PHA polymer was microbially synthesized by engineered Halomonas bluephagenesis and was used as a basal matrix to generate the rare-earth-modified PHA. N-Acetyl-L-cysteine-grafted PHA (NAL-grafted-PHA) was first produced via a UV-initiated thiol−ene click reaction and the rare earth metal ions (Eu 3+ and Tb 3+ ) were subsequently chelated onto the NAL-grafted-PHA through the coordination effect. The composite material exhibited intense photoluminescence properties under UV laser excitation, indicating the excellent features as fluorescent material. The enhanced hydrophilicity and superior biocompatibility of rare-earth-chelated PHA were confirmed, suggesting its great potential application value in biomedical fields.

Tailor‐Made Polyhydroxyalkanoates by Reconstructing Pseudomonas Entomophila

“…The modulation of both monomer compositions and molar ratios of P(3HB ‐co‐ MCL/LCL 3HA) provides a precise regulation mode for customized PHA material properties, including thermal and mechanical properties. As often emphasized, P(3HB ‐co‐ MCL/LCL 3HA) containing unsaturated double bonds for diverse chemical modifications have potentials on high value‐added applications in smart materials and medical fields, [ 56,57 ] for example tissue engineering, [ 58–60 ] drug vehicles, [ 61,62 ] fluorescent materials, [ 63 ] temperature responsive materials, [ 64 ] and other functional materials of multiple uses [ 65 ] etc.…”

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

“…This novel rare earth fluorescent material not only has strong photoluminescence properties, but also has excellent physiological compatibility and enhanced hydrophilicity. [95]…”

“…Flow chart for preparation of high-efficiency fluorescent materials based on rare earth metal ions (Eu 3+ and Tb 3+ ) modified PHA. Reproduced with permission [95]. Copyright 2019, American Chemical Society.…”

Development and Application of Transcription Terminators for Polyhydroxylkanoates Production in Halophilic Halomonas bluephagenesis TD01

“…H. bluephagenesis TD01 is an excellent industrial producer of polyhydroxylkanoates (PHAs), an environmentally friendly biomaterial (Ye et al, 2018). Wildtype H. bluephagenesis TD01 accumulates polyhydroxybutyrate (PHB) up to 80% of the cell dry weight, and numerous functional PHAs with excellent properties have also been achieved by engineered H. bluephagenesis TD01 (Tan et al, 2011;Meng et al, 2014;Yu et al, 2019bYu et al, , 2020Zhang et al, 2022). Tremendous efforts have been made to allow the property improvements of the strain (Tan et al, 2021).…”