Highly efficient dissociation of oxygen from hemoglobin in Tibetan chicken embryos compared with lowland chicken embryos incubated in hypoxia

Liu, C.; Zhang, L. F.; Song, Meirong; Bao, Haigang; Zhao, Chunjiang; Li, N.

doi:10.3382/ps.2009-00311

Cited by 23 publications

(15 citation statements)

References 20 publications

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“…Adaptive lung development has also been reported in mammals living at higher altitudes [38]. E19 is the peak of mortality for embryos growing in both normal and hypoxic conditions [53]. Our data showed relative hypoxic stress at E19 even when embryos are incubated in normal conditions.…”

Section: Discussionsupporting

confidence: 78%

Hypoxia-Induced miR-15a Promotes Mesenchymal Ablation and Adaptation to Hypoxia during Lung Development in Chicken

Hao

et al. 2014

PLoS ONE

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The lungs undergo changes that are adaptive for high elevation in certain animal species. In chickens, animals bred at high elevations (e.g., Tibet chickens) are better able to hatch and survive under high-altitude conditions. In addition, lowland chicken breeds undergo physiological effects and suffer greater mortality when they are exposed to hypoxic conditions during embryonic development. Although these physiological effects have been noted, the mechanisms that are responsible for hypoxia-induced changes in lung development and function are not known. Here we have examined the role of a particular microRNA (miRNA) in the regulation of lung development under hypoxic conditions. When chicks were incubated in low oxygen (hypoxia), miR-15a was significantly increased in embryonic lung tissue. The expression level of miR-15a in hypoxic Tibet chicken embryos increased and remained relatively high at embryonic day (E)16–20, whereas in normal chickens, expression increased and peaked at E19–20, at which time the cross-current gas exchange system (CCGS) is developing. Bcl-2 was a translationally repressed target of miR-15a in these chickens. miR-16, a cluster and family member of miR-15a, was detected but did not participate in the posttranscriptional regulation of bcl-2. Around E19, the hypoxia-induced decrease in Bcl-2 protein resulted in apoptosis in the mesenchyme around the migrating tubes, which led to an expansion and migration of the tubes that would become the air capillary network and the CCGS. Thus, interfering with miR-15a expression in lung tissue may be a novel therapeutic strategy for hypoxia insults and altitude adaptation.

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Section: Discussionsupporting

confidence: 78%

Hypoxia-Induced miR-15a Promotes Mesenchymal Ablation and Adaptation to Hypoxia during Lung Development in Chicken

Hao

et al. 2014

PLoS ONE

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“…Another study by Liu et al . [43] showed that the Hb concentration is the most important factor responsible for ensuring oxygen concentration in the blood under hypoxic conditions. In the present study, we found that the hypoxic environment significantly increased the Hb levels on day 14 compared to the normoxia group in AACs, and similar changes in Hb have also been observed in avian embryos [44].…”

Section: Discussionmentioning

confidence: 99%

High altitude hypoxia as a factor that promotes tibial growth plate development in broiler chickens

et al. 2017

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Tibial dyschondroplasia (TD) is one of the most common problems in the poultry industry and leads to lameness by affecting the proximal growth plate of the tibia. However, due to the unique environmental and geographical conditions of Tibet, no case of TD has been reported in Tibetan chickens (TBCs). The present study was designed to investigate the effect of high altitude hypoxia on blood parameters and tibial growth plate development in chickens using the complete blood count, morphology, and histological examination. The results of this study showed an undesirable impact on the overall performance, body weight, and mortality of Arbor Acres chickens (AACs) exposed to a high altitude hypoxic environment. However, AACs raised under hypoxic conditions showed an elevated number of red blood cells (RBCs) and an increase in hemoglobin and hematocrit values on day 14 compared to the hypobaric normoxia group. Notably, the morphology and histology analyses showed that the size of tibial growth plates in AACs was enlarged and that the blood vessel density was also higher after exposure to the hypoxic environment for 14 days, while no such change was observed in TBCs. Altogether, our results revealed that the hypoxic environment has a potentially new role in increasing the blood vessel density of proximal tibial growth plates to strengthen and enhance the size of the growth plates, which may provide new insights for the therapeutic manipulation of hypoxia in poultry TD.

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“…Experimental models have been created using a wide variety of species. Compared with models in mammals, studies made in bird embryos 107,108 (such as the chicken) are remarkable because their oviparous nature excludes maternal factors (such as stress, maternal hormones, and maternal nutrition) from the list of potential confounding factors in the model. 109 However, the absence of any feto-placento-maternal interactions and the birds' physiological peculiarities make results obtained in this model hard to extrapolate to other species.…”

Section: Animal Species Used To Study Early Programmingmentioning

confidence: 99%

The Early Origins of Cardiovascular Health and Disease: Who, When, and How

2011

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Almost 30 years ago, a series of epidemiological studies popularized the early programming theory that had resulted from observed associations between low birthweight and increased cardiovascular morbidity and mortality later in life. Since then, several clinical and experimental models have been created to understand the principles and mechanisms of this fascinating phenomenon and describe its relevance to the pathophysiology of cardiovascular and many other chronic diseases. Despite the growing body of published evidence, the specific mechanisms mediating early programming effects are still elusive. Moreover, many controversial issues have arisen regarding the characteristics of the most commonly used clinical and experimental models, the existence of potential windows of susceptibility for different organs, and the presence of sex differences in its pathophysiology. Therefore, this review synthesizes some of the antecedents behind the early programming theory and discusses some of the controversial issues surrounding it. Early programming has been extensively linked to several chronic diseases; however, for the purposes of this review we have concentrated on the potential role of this entity in the pathophysiology of chronic cardiovascular diseases.

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Highly efficient dissociation of oxygen from hemoglobin in Tibetan chicken embryos compared with lowland chicken embryos incubated in hypoxia

Cited by 23 publications

References 20 publications

Hypoxia-Induced miR-15a Promotes Mesenchymal Ablation and Adaptation to Hypoxia during Lung Development in Chicken

Hypoxia-Induced miR-15a Promotes Mesenchymal Ablation and Adaptation to Hypoxia during Lung Development in Chicken

High altitude hypoxia as a factor that promotes tibial growth plate development in broiler chickens

The Early Origins of Cardiovascular Health and Disease: Who, When, and How

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