2017
DOI: 10.1021/acsami.7b11107
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Highly Efficient Capture and Electrochemical Release of Circulating Tumor Cells by Using Aptamers Modified Gold Nanowire Arrays

Abstract: The effective capture and release of circulating tumor cells (CTCs) is of significant importance in cancer prognose and treatment. Here we report a highly efficient method to capture and release human leukemic lymphoblasts (CCRF-CEM) using aptamers modified gold nanowire arrays (AuNWs). The gold nanowires, showing tunable morphologies from relatively random pillar deposit to relatively uniform arrays, were fabricated by electrochemical deposition using anodic aluminum oxide (AAO) as template. Upon simply being… Show more

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Cited by 67 publications
(55 citation statements)
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“…For example, comparable Au NWs arrays fabricated by template-assisted electrodeposition have been described as highly efficient platforms for the capture and electrochemical release of circulating human leukemic lymphoblasts (tumor cells) when functionalized with aptamers. [53] By using electrochemical deposition on anodic aluminum oxide as a template, the arrays fabricated were able to capture target cells with much higher yield and to release them with little damage through an electrochemical desorption process. Silicon NWs (150 nm in diameter and 2.6 µm in length) decorated with Au are being also explored as highly efficient near-infrared (NIR) hyperthermia and photothermal agents for cancer treatment.…”
Section: Nanostructured Electrodes Enable Electrical Stimulation Of Bmentioning
confidence: 99%
“…For example, comparable Au NWs arrays fabricated by template-assisted electrodeposition have been described as highly efficient platforms for the capture and electrochemical release of circulating human leukemic lymphoblasts (tumor cells) when functionalized with aptamers. [53] By using electrochemical deposition on anodic aluminum oxide as a template, the arrays fabricated were able to capture target cells with much higher yield and to release them with little damage through an electrochemical desorption process. Silicon NWs (150 nm in diameter and 2.6 µm in length) decorated with Au are being also explored as highly efficient near-infrared (NIR) hyperthermia and photothermal agents for cancer treatment.…”
Section: Nanostructured Electrodes Enable Electrical Stimulation Of Bmentioning
confidence: 99%
“…Compared with thiol‐containing linkers, thiol‐terminal aptamers exhibit more merits for the combined recognition capability of aptamers with convenient modification and desorption of thiol to Au substrate. Xia and co‐workers constructed cell capture‐and‐release platform based on aptamer modified gold nanowire arrays (AuNWs) . With a potential of −1.2 V to treat AuNWs for 30 s, 96.2% of the captured tumor cells were released with excellent cell viability of ≈90% ( Figure a).…”
Section: Ctc Releasementioning
confidence: 99%
“…a) Gold nanowire array platform modified with thiol‐terminal aptamers for CTC release via electrochemical breakage of AuS bond. Reproduced with permission . Copyright 2017, American Chemical Society.…”
Section: Ctc Releasementioning
confidence: 99%
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