Highly efficient and tunable miktoarm stars for HIPE stabilization and polyHIPE synthesis

Horowitz, Rotem; Lamson, Melissa; Cohen, Orit; Fu, Travis; Cuthbert, Julia; Matyjaszewski, Krzysztof; Silverstein, Michael S.

doi:10.1016/j.polymer.2021.123444

Cited by 14 publications

(11 citation statements)

References 66 publications

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“…The 2-acryloxyethyl-2 0 -bromoisobutyrate used in this work was synthesized according to the methods reported in the previous literature. 56 The oil-phase solution was prepared by mixing pretreated styrene (1.7 g), 2-acryloxyethyl-2 0 -bromoisobutyrate (0.8 g), divinylbenzene (0.7 g), and Span 80 surfactant (0.8 g). The mixture was stirred for 1 h at 300 rpm using an overhead stirrer.…”

Section: Preparation Of Polyhipe-br (Phipe-br)mentioning

confidence: 99%

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Macroporous polyHIPE modified with β-cyclodextrin for the removal of bisphenol A from water

et al. 2023

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Section: Preparation Of Polyhipe-br (Phipe-br)mentioning

confidence: 99%

“…ATRP can be adopted to fabricate the polyHIPE platform with functional groups. [53][54][55] Porous polyHIPEs as the polymerization initiator (inimer) can be decorated with different polymer brushes. PolyHIPEs with a high surface area offer an effective platform for loading b-CD, which could improve the adsorption effect for BPA.…”

Section: Introductionmentioning

confidence: 99%

Macroporous polyHIPE modified with β-cyclodextrin for the removal of bisphenol A from water

et al. 2023

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“…A potential alternative to stabilize the non-equilibrium droplet shape is provided by gelation of the continuous phase using polymers, proteins, and low molecular weight gelators, packing the droplets efficiently within the continuous phase. [17][18][19][20][21][22] HIPE droplets dispersed in in-situ gelled continuous phase provide functional micro-compartments mimicking tissues. However, the introduction of hydrogels as the continuous phase to produce a HIPE gel (HIPEG) would offer functionally encoded systems with external stimuli sensitiveness and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

G-quadruplex Hydrogel-based Stimuli-responsive High-internal-phase Emulsion Scaffold for Biocatalytic Cascades and Synergistic Antimicrobial Activity

Das

Solra

Sahoo

et al. 2023

Preprint

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High internal phase emulsions (HIPEs) are non-equilibrium systems with distorted liquid droplet shapes consisting of high volume of internal phase (>74% v/v), enabling high loading of pharmaceutics and useful viscoelastic properties. Stability of the HIPEs is low and requires a high volume of surfactants in the continuous phase, which is environmentally unfriendly. Utilization of hydrogel as the continuous phase to stabilize HIPEs would offer a robust method to produce stable HIPE gels displaying reconfigurable and biocompatible properties, as well as access the huge repertoire of different biocompatible hydrogels. Herein, we introduce a new gel-immobilized HIPE (HIPEG) using chiral G-quadruplex (GQ) based hydrogel with external stimuli-responsive dual-drug release behavior, which is scarce for HIPEs. The hydrophilic and hydrophobic compartments of HIPEGs allow encapsulation of different drugs in both the compartments, with stimuli-responsive diffusion mediated release. Encapsulation of natural oils and antibiotics produces synergistic antimicrobial effects on both Gram positive (MRSA) and Gram negative (P. aeruginosa) bacterial strains. Moreover, we demonstrate biocatalytic reaction networks utilizing compartmentalized enzyme dyads. Notably, the ideal viscoelastic property of HIPEGs enables 3D bioprinting into different shapes, making the scaffold potential for tissue engineering applications. Altogether, our approach offers a one-step route to stimuli-responsive HIPE microcompartments immobilized in GQ hydrogels with endogenous reactivity and high viscoelasticity, and provides a viable step towards the development of biocompatible soft materials with tailorable functionality.

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“…The applicability of HIPEs as biomaterials is often limited by the use of large quantities of surfactants for stabilization, which adversely affect the biocompatibility of the final product. − Recently, research has focused on developing biocompatible and biodegradable components for polyHIPE fabrication, ,, to fulfill the needs of different biological applications. ,− Several studies are dedicated to developing alternative emulsifiers, such as nanoparticles − and polymers, , to minimize the need for surfactants. However, the biocompatibility and cytotoxicity of these materials and their byproducts after degradation must be taken into consideration prior to use.…”

Section: Introductionmentioning

confidence: 99%

Porous Polymerized High Internal Phase Emulsions Prepared Using Proteins and Essential Oils for Antimicrobial Applications

et al. 2022

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High internal phase emulsions (HIPEs) provide a versatile platform for encapsulating large volumes of therapeutics that are immiscible in water. A stable scaffold is obtained by polymerizing the external phase, resulting in polyHIPEs. However, fabrication of polyHIPEs usually requires using a considerable quantity of surfactants along with nonbiocompatible components, which hinders their biological applications, e.g., drug-eluting devices. We describe here a straightforward method for generating porous biomaterials by using proteins as both the emulsifier and the building blocks for the fabrication of polyHIPEs. We demonstrate the versatility of this method by using different essential oils as the internal phase. After the gelation of protein building blocks is triggered by the addition of reducing agents, a stable protein hydrogel containing essential oils can be formed. These oils can be either extracted to obtain protein-based porous scaffolds or slowly released for antimicrobial applications.

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Highly efficient and tunable miktoarm stars for HIPE stabilization and polyHIPE synthesis

Cited by 14 publications

References 66 publications

Macroporous polyHIPE modified with β-cyclodextrin for the removal of bisphenol A from water

Macroporous polyHIPE modified with β-cyclodextrin for the removal of bisphenol A from water

G-quadruplex Hydrogel-based Stimuli-responsive High-internal-phase Emulsion Scaffold for Biocatalytic Cascades and Synergistic Antimicrobial Activity

Porous Polymerized High Internal Phase Emulsions Prepared Using Proteins and Essential Oils for Antimicrobial Applications

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