Highly Efficient and Facile Green Approach for One-Pot Fischer Indole Synthesis

Abstract

요약. HPA-phosphomolybdic acid 촉매 하에서, 아릴히드라진과 알데히드/케톤을 반응시켜서 치환기를 가지고 있는 indole 화 합물을 효율적으로 합성할 수 있는 친환경적인 합성 방법을 개발하였으며, 이때 촉매는 독성이 없으며, 회수하여 재 사용할 수 있다. 주제어: Heteropoly acid, Fischer indole, 아릴히드라진, 알데히드/케톤ABSTRACT. A simple, efficient and an environmental friendly method have been developed for the synthesis of substituted indole from aryl hydrazines and aldehydes/ ketones with HPA-phosphomolybdic acid as a heterogeneous catalyst. The catalyst is nontoxic and recyclable.

Marine Sponge/H3PO4: As a Naturally Occurring Chiral Catalyst for Solvent-free Fischer-Indole Synthesis

“…This procedure involves an acid- catalyzed 3,3-sigmatropic rearrangement of an N-arylhydrazone intermediate, followed by elimination of ammonia. Several Bronsted acids (H 2 SO 4 , HCl, PPA, AcOH, TsOH, and ionic liquids), Lewis acids (ZnCl 2 , TiCl 4 , BiNO 3 , and Sc(OTf) 3 ), and solid acids (zeolite, and Montmorillonite clay) have been reported to catalyze the Fischer-indole synthesis (4-19). Recently, propyl phosphonic acid in combination with cyclic anhydride (T3P) has also been reported recently to catalyze this synthesis (20).…”