Highly efficient and convenient Strecker reaction of carbonyl compounds and amines with TMSCN catalyzed by MCM-41 anchored sulfonic acid as a recoverable catalyst

Expeditious and efficient synthesis of Strecker’s α-aminonitriles catalyzed by sulfated polyborate

“…18 Protocols based on TMSCN often require variety of Lewis or Bronsted acid catalyst such as Pr(OTf) 3 , 19 Yb(OTf), 20 Cu(OTf) 2 32 Montmorillonite KSF, 33 polymer-supported Sc(OTf) 3,34 silica-supported heteropoly acids, 35 cellulose sulfuric acid, 36 alumina supported tungstosilicic acid, 37 SBA-15 supported sulfonic acid, 38 sulfamic acid functionalized magnetic Fe 3 O 4 nanoparticles, 39 H 2 SO 4/ Silica gel, 40 silica-bonded S-sulfonic acid, 41 sulphated tungstate, 42 MCM-41 anchored sulfonic acid, 43 nano magnetic sulfated zirconia, 44 sulfamic acid, 45 and xanthan sulfuric acid. 46 However, many of these methods suffer from several shortcomings such as low reactivity, unsatisfactory yields, moisture sensitive nature, longer reaction time, harsh reaction conditions, tedious workup, generation of toxic byproducts, use of expensive, metal-based, corrosive/toxic catalysts or reagent.…”

Application of Nanocatalysts in Multi-Component Reactions

“…105 Dekamin was also prepared nano mesoporous borosilicate (B-MCM-41) by the modification of MCM-41 with H 3 BO 3 and used this reagent for the promotion of the Strecker reaction. 106 The results indicated that, although the reaction conditions were similar in both of the methods but the reaction times were longer using B-MCM-41.…”

A facile and environmentally benign polyethylene glycol 600-mediated method for the synthesis of densely functionalized 2-aminothiophene derivatives under ultrasonication

“…Lower reaction and purification steps, and high atom economy as well as highly convergent and requiring minimum time compared to multi-step alternative synthetic routs make MCRs good candidates for green organic processes (12)(13)(14)(15)(16)(17)(18)(19). The Gewald reaction is a popular catalytic and one-pot three-component reaction between elemental sulfur, a cyanomethylene containing an electron-withdrawing group and an enolizable carbonyl compound that affords highly substituted 2-aminothiophene derivatives (12,20).…”