Highly efficient and compatible shampoo for use after hair transplant

Abstract

BackgroundSensitive or hyperreactive skin is a common condition defined by prickling, burning, pain, and pruritus. Although this skin problem was initially described on the face, the scalp is often affected. A sensitive scalp can react with irritation to harsh surfactants or other additives which are often present in shampoos. For this reason, we developed a new rinse-off hypertolerant shampoo specifically designed for the hypersensitive and problematic scalp.MethodsThe shampoo formulation is based on an extremely mild surfactant system and contains bisabolol, an anti-irritant and anti-inflammatory ingredient of chamomile. The shampoo is free of additives such as perfumes, silicones, colorants, parabens, paraffins, and betaine. Since skin can remain in a hyperreactive state after wounding, the status after hair transplantation was chosen as a model system to test the shampoo. Scalp condition and compatibility of each volunteer were analyzed by a plastic surgeon directly after hair transplant and after stitch removal. The plastic surgeons also rated whether they would recommend the further use of the test shampoo. Additionally, volunteers completed a self-assessment questionnaire.ResultsFollowing hair transplantation, regular use of the shampoo resulted in a significant reduction in the extent of scabbing and erythema. This was confirmed by dermatological scalp examinations performed by the plastic surgeon as well as in volunteers’ self-assessments. The plastic surgeon highly recommended the further use of the test shampoo after hair transplant to all study participants.ConclusionApplication of the test shampoo demonstrated excellent skin compatibility and product efficacy after hair transplant. The test shampoo significantly reduced the extent of scabs and erythema. Therefore, the shampoo is ideally suited for use after hair transplantation and for the treatment of sensitive scalp. The excellent skin compatibility is because of the mild surfactant system, the calming ingredient bisabolol, and the absence of potentially irritating ingredients.

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

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“…Chamomile was proven to have a proliferative effect on keratinocytes in vitro [34] and in one study, the topical application of Chamomile essential oil lowered the serum IgG1, histamine and IgE level in atopic dermatitis-like mice [35]. It was also proven that Chamomile can increase the permeability of skin for caffeine and salicylic acid [36] and has good hair care properties in shampoo formulations [37]. Sage was shown to reduce axillary malodor levels when used in a deodorant stick [38] and an in vitro study showed that Sage ethanol extract inhibited NGF-induced neuritic outgrowth in an in vitro study based on a PC12 cell-line [39].…”

“…For Chamomile for example, the components showing anti-bacterial activity were identified to be coumarins, flavonoids, phenolic acids, fatty acids and essential oil components [48]. The component bisabolol - which can also be found in Marigold [49] - is known to have anti-irritant and anti-inflammatory properties [37]. Oleanolic acid extracted from Marigold has been proven to be active against Gram-positive and Gram-negative bacteria [50].…”

“…Chamomile was the plant for which the most references investigating anti-pruritic effects could be included. One clinical reference did not show a clear result concerning this effect but two clinical studies on humans [37, 104] and one in vivo reference using an AD mice model [35] did report Chamomile and its constituent bisabolol to relieve itching. Even though there were no publications found studying this effect in dogs, it seems likely that Chamomile might have a similar effect on dog skin as on human and mouse skin.…”

Corneal antinociceptive effect of (-)-α-bisabolol

“…This is due to the fact that it has anti-inflammatory properties and the absence of potentially irritating ingredients (Schweiger et al. 2015 ).…”