Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent

Guo, Chongshen; Yu, Haijun; Feng, Bing; Gao, Weidong; Yan, Mi; Zhang, Zhiwen; Li, Yaping; Liu, Shaoqin

doi:10.1016/j.biomaterials.2015.02.054

Cited by 107 publications

(72 citation statements)

References 39 publications

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“…Taking advantages of these properties, several NP-based photothermal and magnetothermal agents have been investigated on treating metastatic breast cancer. Researchers have studied the effects of single-walled carbon nanotubes,[33] upconversion NPs,[38] (NH 4 ) X WO 3 nanocubes[73] and W 18 O 49 NPs[19] on breast cancer photothermal therapy. By applying a NIR laser beam, the upconversion NPs were able to generate heat that could eliminate tumors by ~100% and suppress distant metastasis.…”

Section: Treatment Of Metastatic Breast Cancer Using Nanoparticlesmentioning

confidence: 99%

Nanoparticles for imaging and treatment of metastatic breast cancer

Wang

Zhang

2016

Expert Opinion on Drug Delivery

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Introduction Metastatic breast cancer is one of the most devastating cancers that have no cure. Many therapeutic and diagnostic strategies have been extensively studied in the past decade. Among these strategies, cancer nanotechnology has emerged as a promising strategy in preclinical studies by enabling early identification of primary tumors and metastases, and by effective killing of cancer cells. Areas covered This review covers the recent progress made in targeting and imaging of metastatic breast cancer with nanoparticles, and treatment using nanoparticle-enabled chemo-, gene, photothermal- and radio-therapies. This review also discusses recent developments of nanoparticle-enabled stem cell therapy and immunotherapy. Expert opinion Nanotechnology is expected to play important roles in modern therapy for cancers, including metastatic breast cancer. Nanoparticles are able to target and visualize metastasis in various organs, and deliver therapeutic agents. Through targeting cancer stem cells, nanoparticles are able to treat resistant tumors with minimal toxicity to healthy tissues/organs. Nanoparticles are also able to activate immune cells to eliminate tumors. Owing to their multifunctional, controllable and trackable features, nanotechnology-based imaging and therapy could be a highly potent approach for future cancer research and treatment.

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Section: Treatment Of Metastatic Breast Cancer Using Nanoparticlesmentioning

confidence: 99%

Nanoparticles for imaging and treatment of metastatic breast cancer

Wang

Zhang

2016

Expert Opinion on Drug Delivery

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“…PTT induces ECM degradation and improves NP delivery to solid tumors by converting near-infrared (NIR) light to local heat. Compared to the conventional modalities for cancer therapy, including surgical resection, chemotherapy and radiotherapy, PTT is noninvasive and induces minimal side effects [50,51] . However, the majority of the NPs employed for PTT are inorganic nanomaterials (eg, gold nanorods and carbon nanomaterials).…”

Section: Overcoming Extracellular Barriers Using Nanomedicinementioning

confidence: 99%

Smart nanoparticles improve therapy for drug-resistant tumors by overcoming pathophysiological barriers

Liu

Wang

et al. 2016

Acta Pharmacol Sin

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The therapeutic outcome of chemotherapy is severely limited by intrinsic or acquired drug resistance, the most common causes of chemotherapy failure. In the past few decades, advancements in nanotechnology have provided alternative strategies for combating tumor drug resistance. Drug-loaded nanoparticles (NPs) have several advantages over the free drug forms, including reduced cytotoxicity, prolonged circulation in the blood and increased accumulation in tumors. Currently, however, nanoparticulate drugs have only marginally improved the overall survival rate in clinical trials because of the various pathophysiological barriers that exist in the tumor microenvironment, such as intratumoral distribution, penetration and intracellular trafficking, etc. Smart NPs with stimulusadaptable physico-chemical properties have been extensively developed to improve the therapeutic efficacy of nanomedicine. In this review, we summarize the recent advances of employing smart NPs to treat the drug-resistant tumors by overcoming the pathophysiological barriers in the tumor microenvironment.

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“…Cs x WO 3 nanorods exhibited absorption in 800-1300 nm with a high extinction coefficient of 4.8 × 10 10 m −1 cm −1 at 980 nm, which was attributed to SPR effect. [265] Photothermal conversion efficiency of 39.4% was recorded using 1064 nm excitation, which was higher than previously mentioned tungsten bronzes. Tian et al synthesized NIR light-responsive PVP-coated Rb x WO 3 for PA, CT imaging, and DOX delivery.…”

Section: Metal Oxidesmentioning

confidence: 57%

Advanced Near‐Infrared Light‐Responsive Nanomaterials as Therapeutic Platforms for Cancer Therapy

Chien

Chan

Anderson

et al. 2018

Advanced Therapeutics

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Cancer is one of the leading causes of death. Despite the huge progress in the field of cancer drugs and therapies, the treatment outcome is still bleak for most cancer patients. Nanotechnology has revolutionized cancer therapeutics. By using nano-sized particles as delivery systems, therapeutic biomolecules are transported efficiently to the target sites. Moreover, these particles are designed to carry out multiple cancer treatments simultaneously. Near-infrared (NIR) light-responsive nanomaterials have gained much attention as NIR light has a greater penetration depth, minimal phototoxicity, lower autofluorescence, and reduced light scattering. Among the available NIR light-responsive nanomaterials, gold nanorods, upconversion nanoparticles, carbon dots, transition metal dichalcogenide, metal oxides, black phosphorus, and polymeric nanomaterials have become attractive options owing to their excellent optical properties, ease of synthesis and modification, outstanding photodynamic and photothermal conversion properties, and most importantly, favorable toxicity level and biocompatibility which are prerequisites for biological applications. In this review, the outstanding properties, synthesis, and surface functionalization of the aforementioned NIR light-responsive nanomaterials are introduced in detail. Recent advances of these nanomaterials for various cancer treatment modalities are summarized to highlight their versatility and potential in cancer theranostics. Finally, a perspective is proposed on future research directions and their clinical translation.

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Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent

Cited by 107 publications

References 39 publications

Nanoparticles for imaging and treatment of metastatic breast cancer

Nanoparticles for imaging and treatment of metastatic breast cancer

Smart nanoparticles improve therapy for drug-resistant tumors by overcoming pathophysiological barriers

Advanced Near‐Infrared Light‐Responsive Nanomaterials as Therapeutic Platforms for Cancer Therapy

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