Highly dynamic changes of regional HBV epidemiology over two decades

Ricco, G.; Coco, B.; Colombatto, P.; Oliveri, Filippo; Cavallone, D.; Bleve, Patrizia; Vianello, Barbara; Romagnoli, V.; Salvati, A; Surace, L.; Bonino, Ferruccio; Brunetto, M.R.

doi:10.1016/j.dld.2022.11.003

Cited by 7 publications

(8 citation statements)

References 16 publications

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“…Similarly, Caviglia et al, 27 in a recent survey on natural history of HDV infection in Italy, showed that HDV infection was still present in a cohort of ageing cirrhotic patients and maintained a discreet impact on liver transplantation programs. Also Ricco et al 30 Moreover, in the present study, upon stratification by RNA positivity, we showed that, in non-Italian natives, the prevalence of HDV-RNA-positive subjects was higher. This result was in line with other studies demonstrating the higher HDV active infection prevalence in immigrants compared to Italian natives.…”

Section: Discussionsupporting

confidence: 77%

“…This result was in line with other studies demonstrating the higher HDV active infection prevalence in immigrants compared to Italian natives. 9,30 Our cohort of HDV viremic patients shows higher transaminases values and higher prevalence of advanced liver fibrosis compared to HDV-RNA negative cohort. The significant association between HDV viraemia and increased ALT levels has also been described in both univariate and multivariate analyses in a cross-sectional study of over 1.500 patients from 15 countries.…”

Section: Discussionmentioning

confidence: 86%

“…Similarly, Caviglia et al, 27 in a recent survey on natural history of HDV infection in Italy, showed that HDV infection was still present in a cohort of ageing cirrhotic patients and maintained a discreet impact on liver transplantation programs. Also Ricco et al 30 demonstrated that the prevalence of cirrhosis in HDV‐positive patients increased in the decade 2010–2019 compared to 2000–2009 years, as a consequence of old infections.…”

Section: Discussionmentioning

confidence: 99%

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Anti‐HDV reflex testing in HBsAg‐positive subjects: An efficacious strategy to identify HDV infection

Cossiga,

Brusa,

Montalti

et al. 2023

Liver International

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Background and AimsThe prevalence of HDV infection in HBsAg carriers is about 9.9% in Italy. However, the real prevalence is underestimated because the anti‐HDV test is not performed routinely in all HBsAg carriers. The aim of this study was to compare the prevalence and the absolute number of HDV infection identified in HBsAg‐positive subjects tested at University Hospital Federico II before and after the introduction of anti‐HDV reflex testing.MethodsFrom January to December 2022, reflex test for the detection of total HDV antibodies was performed in all HBsAg‐positive subjects tested at University Hospital Federico II. The control group consisted of all the HBsAg‐positive subjects tested at the same laboratory in 2019, before the implementation of anti‐HDV reflex testing. Sera were evaluated with ADVIA Centaur HBsAgII Qualitative, Liaison Murex HBsAg Quantitative and Liaison Murex Total Anti‐HDV Qualitative.ResultsBefore reflex testing, anti‐HDV had been tested in 16.4% (84/512) of HBsAg‐positive subjects, while after its implementation, 100% (484/484) of HBsAg‐positive patients was tested for anti‐HDV. The anti‐HDV positive prevalence was lower than before the introduction of reflex test (10.7% vs. 16.6%) but the absolute number of anti‐HDV positive patients increased (14 vs. 52 subjects). HDV‐RNA was detectable in 26 (53%) of 49 tested subjects.ConclusionsOur data showed that the implementation of anti‐HDV reflex testing increased the diagnoses of HDV infection. In this setting, due to the approval of specific anti‐HDV drugs, a reflex test for anti‐HDV should be implemented to early identify patients with HBV/HDV infection.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 86%

“…Similarly, Caviglia et al, 27 in a recent survey on natural history of HDV infection in Italy, showed that HDV infection was still present in a cohort of ageing cirrhotic patients and maintained a discreet impact on liver transplantation programs. Also Ricco et al 30 demonstrated that the prevalence of cirrhosis in HDV‐positive patients increased in the decade 2010–2019 compared to 2000–2009 years, as a consequence of old infections.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anti‐HDV reflex testing in HBsAg‐positive subjects: An efficacious strategy to identify HDV infection

Cossiga,

Brusa,

Montalti

et al. 2023

Liver International

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Section: Introductionmentioning

confidence: 99%

“…Prospective studies have shown that the annual incidence of chronic HBV infection developing into cirrhosis is 2 to 10%, and liver cirrhosis is a common cause of death in gastrointestinal diseases. [3] Research shows that etiological treatment can help inhibit or even reverse liver fibrosis, which can effectively inhibit viral replication and reverse liver fibrosis in chronic hepatitis B. [4] However, there are still some limitations in the treatment of liver fibrosis.…”

Section: Introductionmentioning

confidence: 99%

The mechanism of peach kernel and safflower herb-pair for the treatment of liver fibrosis based on network pharmacology and molecular docking technology: A review

Huang

Peng

et al. 2023

Medicine

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Peach kernel and safflower herb-pair (PKSH) are widely used in traditional Chinese medicine for the treatment of liver fibrosis. Therefore, network pharmacology was performed to explore potential therapeutic targets and pharmacological mechanisms of PKSH. The active components of PKSH from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database and potential targets of liver fibrosis from the Online Mendelian Inheritance in Man, Pharmacogenetics and Pharmacogenomics Knowledge Base, GeneCards, and DrugBank Database were identified. The protein-protein interaction network was constructed using Cytoscape (v3.8.0). Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed for the treatment of liver fibrosis, and molecular docking was carried out to verify the results of network pharmacology analysis. After screening disease-related genes, 179 intersection genes overlapped between 196 target proteins of the active compound and 9189 potential disease targets. Furthermore, we obtained 15 hub nodes and 146 edges to establish a related network diagram using CytoNCA. 2559 Gene Ontology biological processes underlying PKSH have been explored for the treatment of liver fibrosis, in which the response to oxidative stress plays a vital role. Furthermore, Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that PKSH might play a role in inhibiting liver fibrosis, mainly through the PI3K-Akt signaling pathway. PKSH can regulate the response to oxidative stress through the PI3K-Akt signaling pathway for the treatment of liver fibrosis. The main bioactive components in PKSH, including quercetin and luteolin, can activate the PI3K-Akt signaling pathway by binding with the hub targets of the disease, which may provide insights into drug development for liver fibrosis.

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A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort

Kondili,

Brancaccio,

Tosti

et al. 2024

International Journal of Infectious Diseases

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Highly dynamic changes of regional HBV epidemiology over two decades

Cited by 7 publications

References 16 publications

Anti‐HDV reflex testing in HBsAg‐positive subjects: An efficacious strategy to identify HDV infection

Anti‐HDV reflex testing in HBsAg‐positive subjects: An efficacious strategy to identify HDV infection

The mechanism of peach kernel and safflower herb-pair for the treatment of liver fibrosis based on network pharmacology and molecular docking technology: A review

A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort

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