Abstract:Cancer (COSMIC) database and mapped on the TRPA1 structure. TRPA1 structures harbouring OAC mutations were simulated in order to inform alterations in structure-function relationships of the channel and propose ways by which mutations promote cancer. Notably, we observe clustering of cancer mutations around dynamic hinges in the intracellular ankyrin repeat region of the structure. We propose that missense mutations observed in OAC promote cancer via TRPA1 activation by altering protein dynamics. Increasing ev… Show more
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