Highly dynamic biodegradable micelles capable of lysing Gram-positive and Gram-negative bacterial membrane

Qiao, Yuan; Yang, Chuan; Coady, Daniel J.; Ong, Zhan Yuin; Hedrick, James L.; Yang, Yi-Yan

doi:10.1016/j.biomaterials.2011.10.020

Cited by 163 publications

(171 citation statements)

References 19 publications

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“…Yang and Hedrick et al studied the molecular weight effect on antimicrobial poly(carbonate)s [133]. They also observed similar trends with Gram-positive activity for low molecular weight polycarbonates and the reverse trend for Gram-negative bacteria such as E. coli and P. aeruginosa.…”

Section: Molecular Weight Effectmentioning

confidence: 61%

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Controlling macromolecular structures towards effective antimicrobial polymers

Ganewatta

Tang

2015

Polymer

219

255

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Section: Molecular Weight Effectmentioning

confidence: 61%

“…In another study, Hedrick, Yang and coworkers developed highly dynamic, biodegradable micelles from poly(carbonate)s that demonstrated stronger bactericidal properties [133]. The micelles from random poly(carbonate)s showed stronger activity against Gram-negative bacteria, compared to block copolymers.…”

Section: Antimicrobial Polymer Assembliesmentioning

confidence: 97%

Controlling macromolecular structures towards effective antimicrobial polymers

Ganewatta

Tang

2015

Polymer

219

255

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“…Since MTC-ethyl and MTC-(CH 2 ) 3 Br have similar reactivity, both monomers should be dispersed randomly throughout the polymeric chain. [ 18 ] The alkyl bromide in the block copolymer was quaternized with trimethylamine to yield the targeted cationic block copolymers (APCs). These APCs have narrow molecular weight distributions (polydispersity indices: 1.19-1.26) and well-defi ned structure, where the compositions and molecular weights of the APCs are in good agreement with initial monomer to initiator feed ratios ( 1 H-NMR spectrum ( Figure S1 in the Supporting Information).…”

Section: Doi: 101002/adma201202225mentioning

confidence: 99%

Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition

et al. 2012

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A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad-spectrum antimicrobial activities against various clinically isolated multidrug-resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.

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“…Host defence peptides and synthetic polymers are two classes of macromolecules currently being studied as effective antimicrobials [8][9][10][11] . These materials are amphiphilic while also carrying cationic charge.…”

mentioning

confidence: 99%

Supramolecular high-aspect ratio assemblies with strong antifungal activity

Fukushima

Liu

et al. 2013

Nat Commun

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Efficient and pathogen-specific antifungal agents are required to mitigate drug resistance problems. Here we present cationic small molecules that exhibit excellent microbial selectivity with minimal host toxicity. Unlike typical cationic polymers possessing molecular weight distributions, these compounds have an absolute molecular weight aiding in isolation and characterization. However, their specific molecular recognition motif (terephthalamidebisurea) facilitates spontaneous supramolecular self-assembly manifesting in several polymer-like properties. Computational modelling of the terephthalamide-bisurea structures predicts zig-zag or bent arrangements where distal benzyl urea groups stabilize the highaspect ratio aqueous supramolecular assemblies. These nanostructures are confirmed by transmission electron microscopy and atomic force microscopy. Antifungal activity against drug-sensitive and drug-resistant strains with in vitro and in vivo biocompatibility is observed. Additionally, despite repeated sub-lethal exposures, drug resistance is not induced. Comparison with clinically used amphotericin B shows similar antifungal behaviour without any significant toxicity in a C. albicans biofilm-induced mouse keratitis model.

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Highly dynamic biodegradable micelles capable of lysing Gram-positive and Gram-negative bacterial membrane

Cited by 163 publications

References 19 publications

Controlling macromolecular structures towards effective antimicrobial polymers

Controlling macromolecular structures towards effective antimicrobial polymers

Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition

Supramolecular high-aspect ratio assemblies with strong antifungal activity

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