Highly Differentiated Plantar Verrucous Carcinoma Secondary to Neuropathy Leprosy Ulcer: Case Report and Literature Review

Abstract

Malignant transformation of chronic trophic ulcers in leprosy is not rare as it had been considered to be in the past. We described a case of a 77-year-old man diagnosed with lepromatous leprosy (LL) fiftyeight years ago, and skin ulcer initially occurred on the sole of his right foot because of neurovascular dystrophic and had been existing during the last five decades, which had gradually grown into a “cauliflower-like” tumor with mild pain and spontaneous bleeding over last 3 years. No improvement was achieved after oral antibiotic and topical treatment. The patient underwent tumor excision and four toes amputation after the diagnosis of verrucous carcinoma based on lesion histopathologic examination. After 1year follow-up, no metastasis was found.