Highly degradable imine-doped mesoporous silica particles

Travaglini, Leana; Picchetti, Pierre; Totovao, Ricardo; Prasetyanto, Eko Adi; Cola, Luisa De

doi:10.1039/c8qm00438b

Cited by 25 publications

(31 citation statements)

References 41 publications

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“…Interestingly, the diimine-bridged MONs could be highly degradable, and the enhanced degradation occurred with decreasing the pH value of solution. 50…”

Section: Mons With Ph-triggered Degradationmentioning

confidence: 99%

Mesoporous organosilica nanoparticles: Degradation strategies and application in tumor therapy

Guan

Chen

Tian

et al. 2021

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Biodegradation is a crucial issue for silica-based mesoporous nanoparticles that is related to the biosafety in tumor therapy. Nowadays, mesoporous silica nanoparticles (MSNs) have been intensively developed to construct multifunctional nanosystems for tumor therapy due to their biocompatibility, high drug loading capacity and easy functionalization; however, their biodegradation is relatively slow and still under debate. To improve the biodegradability of silica-based mesoporous nanoparticles, a simple organic-inorganic hybridization strategy to synthesize mesoporous organosilica nanoparticles (MONs) has been successfully developed. By hybridizing the silica framework (-Si-O-Si-) with stimuli-sensitive organic moieties to form organic-inorganic network (-Si-R-Si-, R: organic moiety), when exposed to the stimuli environment, the breakdown of the organic-inorganic network could accelerate the degradation of MONs, which is great promising for MONs as a multifunctional therapeutic nanoplatform in tumor therapy. This review aims to summarize the degradation strategies for MONs to improve biodegradability in recent years, and highlight the potential applications of MONs in tumor therapy. Finally, we also discuss the challenges of MONs for tumor therapy in future clinical translation.

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“…Interestingly, the diimine-bridged MONs could be highly degradable, and the enhanced degradation occurred with decreasing the pH value of solution. 50…”

Section: Mons With Ph-triggered Degradationmentioning

confidence: 99%

Mesoporous organosilica nanoparticles: Degradation strategies and application in tumor therapy

Guan

Chen

Tian

et al. 2021

VIEW

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“…[ 113 ] The peptide section in the framework could be quickly decomposed after exposure to the protease trypsin, with deconstruction of the nanostructure. The other organic moieties, including tetrasulfide, [ 68,114 ] imine, [ 115 ] and oxamide [ 116,117 ] were also introduced as breakable bridging groups for the fabrication of biodegradable MONs.…”

Section: Tuning Siliceous Framework By Incorporation Of Organic Speciesmentioning

confidence: 99%

Tuning Nanosiliceous Framework for Enhanced Cancer Theranostic Applications

et al. 2021

Advanced Therapeutics

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As nanotechnology rapidly advances, siliceous nanomaterials have become increasingly examined for biomedical applications. To further expand their advantageous physicochemical properties and counter intrinsic limitations challenging their progress toward clinical translation, strategies ranging from new fabrication methods to diverse forms of modifications have been proposed. Among them, direct incorporation of foreign species into the siliceous frameworks has emerged. The incorporation of inorganic or organic moieties into an otherwise purely siliceous framework enriches the structure with novel or improved properties. In this review, the progress of inorganic modification is mainly examined on mesoporous silica nanoparticles (MSNs) due to their widely appreciated attributes that garnered them an important position within cancer nanomedicine, while organic modifications are studied through designs of mesoporous organosilica nanoparticles (MONs). General synthesis methods and philosophies behind framework modifications are first discussed in brief. Subsequently, several interesting inorganically doped MSNs and formulations of MONs are studied for their advantages, including the role of catalysis after metal impregnation, improved biodegradability, novel stimuli‐responsiveness, role in bioimaging, and enhancing the outcomes of key treatment strategies. Finally, the advances are summarized, along with proposed prospects for these hybrid materials in their progress toward clinical use.

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“…Although these innovative organosilicas displayed time‐dependent biodegradation behavior in various bio‐mimicking environments, the examination of the critical degradation behavior and characterization of the resultant end products have not yet been thoroughly explored, requiring precise mechanisms related to redox‐triggered and hydrolysis‐induced degradation 118a,b. In another case, De Cola and coworkers demonstrated the finely controlled degradation of MSNs by incorporating the stimuli‐responsive imine groups, which resulted in a faster degradation rate in both acidic and neutral environments . In conclusion, the degradation rate of MSNs depends on the functionalization, the degree of silica condensation and particle size, and the pore morphology.…”

Section: Interesting Attributesmentioning

confidence: 99%

Metal Species–Encapsulated Mesoporous Silica Nanoparticles: Current Advancements and Latest Breakthroughs

Kankala

Zhang

Liu

et al. 2019

Adv Funct Materials

126

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Despite their advantageous morphological attributes and attractive physicochemical properties, mesoporous silica nanoparticles (MSNs) are merely supported as carriers or vectors for a reason. Incorporating various metal species in the confined nanospaces of MSNs (M-MSNs) significantly enriches their mesoporous architecture and diverse functionalities, bringing exciting potentials to this burgeoning field of research. These incorporated guest species offer enormous benefits to the MSN hosts concerning the reduction of their eventual size and the enhancement of their performance and stability, among other benefits. Substantially, the guest species act through contributing to reduced aggregation, augmented durability, ease of long-term storage, and reduced toxicity, attributes that are of particular interest in diverse fields of biomedicine. In this review, the first aim is to discuss the current advancements and latest breakthroughs in the fabrication of M-MSNs, emphasizing the pros and cons, the confinement of various metal species in the nanospaces of MSNs, and various factors influencing the encapsulation of metal species in MSNs. Further, an emphasis on potential applications of M-MSNs in various fields, including in adsorption, catalysis, photoluminescence, and biomedicine, among others, along with a set of examples is provided. Finally, the advances in M-MSNs with perspectives are summarized.(2-5 nm), tunable sizes (50-150 nm), shapes (hexagonal, wormhole-like, cubic, and lamellar) and morphologies (spheres, helical fibers, tubules, gyroids, crystals, and numerous other hierarchical complex architectures), ease of surface functionalization (both interior as well as exterior), unique topology, colloidal and thermal stabilities, and high dispersity. [4] The exceptional topology of surfactant-templated MSNs makes them unique with desirable properties that can be obtained by controlling the preparation conditions, such as the reaction temperature, pH value, stirring speed, and type of silica source, as well as surfactant, among others. [4j,m,n,5] These advantages make the MSNs as versatile materials and ideal choice for catalysis, [6] adsorption, [7] optical devices, [4j] polymeric fillers, [8] and diverse biomedical applications including bio-imaging, [4r,t,u,9] biocatalysts, [10] biosensing, [11] tissue engineering, [4f ] and drug/ gene delivery accounting for targeted and controlled release systems. [3d,4i,o-t,v,12] With these significant advantages and attractive physicochemical properties, it is highly anticipated to harness the desirable and beneficial properties of MSNs through the incorporation of various metals and their respective conjugates for exploration in innovative applications with exceptional performance. [13] The encapsulated metal species in the confined nanospaces of MSNs (M-MSNs) not only significantly enrich the mesoporous architecture and functionalities of MSN, but also tend to overcome their intrinsic limitations, such as their poor suspension ability and stability, lack of intrig...

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Highly degradable imine-doped mesoporous silica particles

Abstract: Enhanced degradation of mesoporous silica particles in neutral and acidic aqueous solutions was achieved by embedding diimine moieties in the silica network.

Cited by 25 publications

References 41 publications

Mesoporous organosilica nanoparticles: Degradation strategies and application in tumor therapy

Mesoporous organosilica nanoparticles: Degradation strategies and application in tumor therapy

Tuning Nanosiliceous Framework for Enhanced Cancer Theranostic Applications

Metal Species–Encapsulated Mesoporous Silica Nanoparticles: Current Advancements and Latest Breakthroughs

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