Highly Cytokinergic IgE Antibodies and Autoimmune Mechanisms

Kim, Mi-Ae; Park, Hae‐Sim

doi:10.4168/aair.2012.4.6.311

Cited by 7 publications

(10 citation statements)

References 17 publications

(27 reference statements)

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“…This notion is supported by new findings that point to IgE‐mediated autoimmunity as a cause of CSU in a subpopulation of patients. In that regard, highly cytokinergic IgE antibodies with polyreactivity to autoantigens including thyroid peroxidase (TPO) in the sera from patients with atopic dermatitis, which could induce mast cell activation, have been reported by Kim and Park . IgE against TPO is a common feature of patients with CSU.…”

Section: Resultsmentioning

confidence: 99%

“…In that regard, highly cytokinergic IgE antibodies with polyreactivity to autoantigens including thyroid peroxidase (TPO) in the sera from patients with atopic dermatitis, which could induce mast cell activation, have been reported by Kim and Park. 77 IgE against TPO is a common feature of patients with CSU. A relation of IgE and thyroid autoimmunity has been observed in CSU.…”

Section: Laboratory Markers Of Severity and Prognosismentioning

confidence: 99%

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Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

Sánchez‐Borges

Caballero‐Fonseca

Capriles‐Hulett

et al. 2017

Acad Dermatol Venereol

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Biomarkers useful for the evaluation and management of patients with chronic spontaneous urticaria (CSU) are not currently available. A review of various clinical and laboratory markers that have been studied to assess their value for determining the severity or predicting the evolution of disease in adult patients with CSU was carried out. A search of the medical literature on PubMed and MEDLINE including the terms urticaria, chronic urticaria, chronic idiopathic urticaria, CSU, severity, prognosis and treatment was performed. Based on our review of the literature, among the clinical markers studied, higher age at onset, being female, long disease duration and aspirin/NSAID hypersensitivity may be linked to both severe CSU and a long time to spontaneous remission. In addition, a positive autologous serum skin test (ASST) may be associated with severe CSU, and comorbidity of inducible urticaria and concomitant recurrent angio-oedema may be linked to longer CSU duration. Potential biomarkers of CSU severity and/or duration include basophil numbers and susceptibility to activation, inflammatory markers, markers of activation of the extrinsic coagulation pathway, immunoglobulin E and vitamin D. Although the described markers are promising, further studies on representative and well-characterized patient populations are needed to determine the value of these clinical and biological markers for predicting the severity and course of disease in patients with CSU.

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Section: Resultsmentioning

confidence: 99%

Section: Laboratory Markers Of Severity and Prognosismentioning

confidence: 99%

Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

Sánchez‐Borges

Caballero‐Fonseca

Capriles‐Hulett

et al. 2017

Acad Dermatol Venereol

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“…Various types of serum autoantibody, such as ANA and IgGs against thyroglobulin and thyroid peroxidase (TPO), were elevated in sera from CU patients, although it is unknown how these autoantibodies are involved in the pathogenic mechanism 3,7,27. One recent study demonstrated the presence of highly cytokinergic serum IgE antibodies specific for various autoantigens, such as TPO on the mast cell surface, which could activate mast cells 28. When mast cells are triggered, they release preformed mediators, and subsequently leukotrienes, prostaglandins, cytokines, and chemokines, which aggravate chronic inflammation 29,30.…”

Section: The Candidate Gene Approach In Cumentioning

confidence: 99%

Molecular Genetic Mechanisms of Chronic Urticaria

Losol

Yoo

Park

2014

Allergy Asthma Immunol Res

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Chronic urticaria (CU) is a common allergic skin disease that requires long-term pharmacological treatment. Some patients with severe CU suffer a poor quality of life. Although the pathogenic mechanisms of CU are not clearly understood, several groups have suggested that genetic mechanisms are involved in various CU cohorts. To further understand the molecular genetic mechanisms of CU, we summarize recent genetic data in this review. Although a few HLA alleles were suggested to be candidate markers in different ethnic groups, further replication studies that apply the recent classification are needed. Genetic polymorphisms in histamine-related genes, including FcεRI and HNMT, were suggested to be involved in mast cell activation and histamine metabolism. Several genetic polymorphisms of leukotriene-related genes, such as ALOX5, LTC4S, and the PGE2 receptor gene PTGER4, were suggested to be involved in leukotriene overproduction, a pathogenic mechanism. Further investigations using candidate gene approaches and genome-wide association studies (GWAS) will provide new insights into the molecular genetic mechanisms of CU, which will provide new marker genes for differentiation of CU phenotypes and identification of potential therapeutic targets.

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“…A recent study demonstrated the presence of highly cytokinergic IgE antibodies with polyreactivity to autoantigens including TPO in sera of atopic dermatitis patients, which could induce mast cell activation ( 10 ), and Altrichter et al ( 11 ) reported that some of chronic spontaneous urticaria patients expressed IgE antibodies against TPO as a novel pathomechanism of chronic urticaria. However, they could not confirm whether these antibodies directly activate effector cells in chronic urticaria.…”

Section: Introductionmentioning

confidence: 99%

Serum Specific IgE to Thyroid Peroxidase Activates Basophils in Aspirin Intolerant Urticaria

et al. 2015

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Thyroid antibodies are frequently observed in urticaria patients, but their roles in urticaria are not clearly elucidated. We investigated the role of serum specific IgE to thyroid peroxidase (TPO) in patients with aspirin intolerant acute urticaria (AIAU) and aspirin intolerant chronic urticaria (AICU). We recruited 59 AIAU and 96 AICU patients with 69 normal controls (NC). Serum specific IgE to TPO was measured by manual direct ELISA, and CD203c expressions on basophil with additions of TPO were measured to prove a direct role of TPO in effector cells. The prevalences of serum specific IgE to TPO were significantly higher in AIAU (15.2%) and AICU groups (7.5%) compared to NC (0%, P=0.018: P=0.013, respectively). Flow cytometry showed CD203c induction in a dose dependent manner with serial additions of TPO in some AIAU and AICU patients having high specific IgE to TPO. Our findings show that the prevalence of serum specific IgE to TPO was significantly higher in both AIAU and AICU patients than in NC. It is suggested that specific IgE to TPO play a pathogenic role in AIAU and AICU.Graphical Abstract

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Highly Cytokinergic IgE Antibodies and Autoimmune Mechanisms

Cited by 7 publications

References 17 publications

Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

Molecular Genetic Mechanisms of Chronic Urticaria

Serum Specific IgE to Thyroid Peroxidase Activates Basophils in Aspirin Intolerant Urticaria

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