Highly Biocompatible, Fluorescence, and Zwitterionic Carbon Dots as a Novel Approach for Bioimaging Applications in Cancerous Cells

Sri, Smriti; Kumar, Robin; Panda, Amulya K.; Solanki, Pratima R.

doi:10.1021/acsami.8b13217

Cited by 63 publications

(38 citation statements)

References 68 publications

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“…The first approach is based on the breakdown of large graphite materials in smaller carbon-based materials [16]. However, bottom-up methods, such as microwave-assisted processes [17][18][19][20], appear to be the most widely used for the preparation of CDs, which consist of the synthesis of CDs from smaller carbon precursors (small organic molecules) [21,22]. Among these, citric acid (CA) is one of the most used [17,[23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Environmental Impact and Efficiency of N-Doping Strategies in the Synthesis of Carbon Dots

Christé

Silva

2020

Materials

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The efficiency and associated environmental impacts of different N-doping strategies of carbon dots (CDs) were evaluated. More specifically, N-doped CDs were prepared from citric acid via two main synthesis routes: Microwave-assisted hydrothermal treatment with addition of N-containing small organic molecules (urea and ethylenediamine (EDA)); and microwave-assisted solvothermal treatment in N-containing organic solvents (n,n-dimethylformamide (DMF), acetonitrile and pyridine). These syntheses produced CDs with similar blue emission. However, XPS analysis revealed that CDs synthesized via both hydrothermal routes presented a better N-doping efficiency (~15 at.%) than all three solvothermal-based strategies (0.6–7 at.%). However, from the former two hydrothermal strategies, only the one involving EDA as a nitrogen-source provided a non-negligible synthesis yield, which indicates that this should be the preferred strategy. This conclusion was supported by a subsequent life cycle assessment (LCA) study, which revealed that this strategy is clearly the most sustainable one from all five studied synthesis routes.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Environmental Impact and Efficiency of N-Doping Strategies in the Synthesis of Carbon Dots

Christé

Silva

2020

Materials

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“…Compared to other fluorescent nanomaterials, the C‐dots can be easily synthesized from different kind of sources including organic molecules, biowastes, proteins, amino acids, and so on . Moreover, the surface of C‐dots can be modified with several capping agents to improve their fluorescence properties according to the applications . That's why the C‐dots have been extensively utilized in the fields of chemo‐ and biosensors, and optoelectronic applications.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Nanohybrid of Palladium Nanoparticles Encapsulated by Carbon‐Dots for Exploiting Synergetic Applications

Dhenadhayalan

Hsin

Lin

2019

Adv Materials Inter

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and textile. [2,7] It can be readily bound to biomolecules and consequently used as a strain to tissue and cells. [8] However, the application of abnormal level of EY becomes toxic and unfriendly to both the environment and living things. The development of reduction/degradation of nitro compound and dye is thus much needed to convert these materials into harmless products. For instance, the 4-NP and EY could be catalytically reduced into the formation of 4-aminophenol and reduced form of EY, respectively, and believe that this process could become potentially an effective way to treat 4-NP and EY in polluted water. Accordingly, the design and development of proficient catalyst are a significant task for the catalytic reduction of 4-NP and EY with aspects of the efficient and fast process. The nanomaterial-based catalysts are enormously developed for their superior catalytic performance in the reduction of pollutants. [9][10][11][12][13] In general, metal nanoparticles are usually adopted for the catalysis application; especially palladium nanoparticles (Pd NPs) exhibited excellent catalytic activities. [14][15][16] Such metal nanoparticles play a vital role in the catalytic reduction showing effective performance compared to other bare nanomaterials. In order to further improve their catalytic activity, the metal nanoparticles were incorporated with diverse nanomaterials including carbon-based materials, transition metal dichalcogenides (TMD), and porous organic cages. [17][18][19][20][21][22][23][24][25] Compared to other fluorescent nanomaterials, the C-dots can be easily synthesized from different kind of sources including organic molecules, biowastes, proteins, amino acids, and so on. [26][27][28][29][30][31][32] Moreover, the surface of C-dots can be modified with several capping agents to improve their fluorescence properties according to the applications. [33][34][35][36][37] That's why the C-dots have been extensively utilized in the fields of chemo-and biosensors, and optoelectronic applications. Thus far, the C-dots are much less utilized in the catalysis as in the sensing application. By taking advantage of C-dots and Pd NPs, this work aims to develop a superior multifunctional nanohybrid in the multiple applications including chemical sensor and catalysis.With this intention, we have synthesized carbon-dots to encapsulate palladium nanoparticles (Pd/C-dots) by the photochemical method. Prior to the synthesis of Pd/C-dots, Palladium nanoparticles encapsulated in the carbon dots (Pd/C-dots) are demonstrated to play a role of multifunctional nanohybrid in the synergetic applications of sensor and catalysis. The photochemical method is applied to synthesize Pd/C-dots in which Pd nanoparticles (NPs) are dispersedly encapsulated by C-dots layer. The nanohybrid can function as a fluorescent sensor and reductive catalyst, due to the inherent properties of C-dots and Pd NPs, respectively. The Pd/C-dots exhibit a highly selective and sensitive detection toward the nickel (Ni 2+ ) ion with a detection limit of ...

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“…Many synthesis methods have been developed so far, in particular bottom-up routes based on the polymerization and carbonization of the molecular precursors [3]. Several syntheses employ citric acid as a precursor [4,5], which has the advantage of being highly biocompatible [6]. The quantum yield (QY) of the product is in general in the range of 5-15%, which is quite low in comparison to C-dots obtained with other precursors [7].…”

Section: Introductionmentioning

confidence: 99%

Reversible Aggregation of Molecular-Like Fluorophores Driven by Extreme pH in Carbon Dots

et al. 2020

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The origin of carbon-dots (C‑dots) fluorescence and its correlation with the dots structure still lack a comprehensive model. In particular, the core-shell model does not always fit with the experimental results, which, in some cases, suggest a molecular origin of the fluorescence. To gain a better insight, we have studied the response of molecular-like fluorophores contained in the C‑dots at extreme pH conditions. Citric acid and urea have been employed to synthesize blue and green‑emitting C‑dots. They show a different emission as a function of the pH of the dispersing media. The photoluminescence has been attributed to molecular-like fluorophores: citrazinic acid and 4‑hydroxy‑1H‑pyrrolo[3,4‑c]‑pyridine‑1,3,6‑(2H,5H)-trione. 3D and time‑resolved photoluminescence, ultraviolet–visible (UV–vis) spectroscopy, and dynamic light scattering have been used to determine the aggregation state, quantum yield and emission properties of the C-dots. The dependence of the C-dots blue and green components on the chemical environment indicates that the origin of fluorescence is due to molecular-like fluorophores.

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Highly Biocompatible, Fluorescence, and Zwitterionic Carbon Dots as a Novel Approach for Bioimaging Applications in Cancerous Cells

Cited by 63 publications

References 68 publications

Evaluation of the Environmental Impact and Efficiency of N-Doping Strategies in the Synthesis of Carbon Dots

Evaluation of the Environmental Impact and Efficiency of N-Doping Strategies in the Synthesis of Carbon Dots

Multifunctional Nanohybrid of Palladium Nanoparticles Encapsulated by Carbon‐Dots for Exploiting Synergetic Applications

Reversible Aggregation of Molecular-Like Fluorophores Driven by Extreme pH in Carbon Dots

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