Highly and Adaptively Undersampling Pattern for Pulmonary Hyperpolarized <sup>129</sup>Xe Dynamic MRI

Xiao, Sa; He, Di; Duan, Caohui; Xie, Junshuai; Li, Haidong; Sun, Xiaofeng; Ye, Chaohui; Zhou, Xin

doi:10.1109/tmi.2018.2882209

Cited by 10 publications

(16 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown 1 H MRI is a promising method for imaging lung ventilation function without radioactivity [24][25][26][27][28][29][30][31][32]. Howbeit, most methods do not visualize dynamic process of ventilation and might conceal some abnormal regions [33,34]. Recently a phase-resolved functional lung (PREFUL) MRI method was proposed to quantify regional dynamic ventilation using pulmonary free-breathing 1 H MRI acquisition [35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Abnormal dynamic ventilation function of COVID-19 survivors detected by pulmonary free-breathing proton MRI

Wang

Xiao

et al. 2022

Eur Radiol

Self Cite

View full text Add to dashboard Cite

Objectives To visualize and quantitatively assess regional lung function of survivors of COVID-19 who were hospitalized using pulmonary free-breathing 1 H MRI. Methods A total of 12 healthy volunteers and 27 COVID-19 survivors (62.4 ± 8.1 days between infection and image acquisition) were recruited in this prospective study and performed chest 1 H MRI acquisitions with free tidal breathing. Then, conventional Fourier decomposition ventilation (FD-V) and global fractional ventilation (FV Global ) were analyzed. Besides, a modified PREFUL (mPREFUL) method was developed to adapt to COVID-19 survivors and generate dynamic ventilation maps and parameters. All the ventilation maps and parameters were analyzed using Student’s t -test. Pearson’s correlation and a Bland-Altman plot between FV Global and mPREFUL were analyzed. Results There was no significant difference between COVID-19 and healthy groups regarding a static FD-V map (0.47 ± 0.12 vs 0.42 ± 0.08; p = .233). However, mPREFUL demonstrated lots of regional high ventilation areas (high ventilation percentage (HVP): 23.7% ± 10.6%) existed in survivors. This regional heterogeneity (i.e., HVP) in survivors was significantly higher than in healthy volunteers ( p = .003). The survivors breathed deeper (flow-volume loop: 5375 ± 3978 vs 1688 ± 789; p = .005), and breathed more air in respiratory cycle (total amount: 62.6 ± 19.3 vs 37.3 ± 9.9; p < .001). Besides, mPREFUL showed both good Pearson’s correlation ( r = 0.74; p < .001) and Bland-Altman consistency (mean bias = −0.01) with FV Global . Conclusions Dynamic ventilation imaging using pulmonary free-breathing 1 H MRI found regional abnormity of dynamic ventilation function in COVID-19 survivors. Key Points • Pulmonary free-breathing 1 H MRI was used to visualize and quantitatively assess regional lung ventilation function of COVID-19 survivors. • Dynamic ventilation maps generated from 1 H MRI were more sensitive to distinguish the COVID-19 and healthy groups (total air amount: 62.6 ± 19.3 vs 37.3 ± 9.9; p < .001), compared with static ventilation maps (FD-V value: 0.47 ± 0.12 vs 0.42 ± 0.08; p = .233). • COVID-19 survivors had larger regional heterogeneity (high ventilation percentage: 23.7% ± 10.6% vs 13.1% ± 7.9%; p = .003), and breathed deeper (flow-volume loop: 5375 ± 3978 vs 1688 ± 789; p = .005) than healthy volunteers. Supplementary Information The online version c...

show abstract

Section: Introductionmentioning

confidence: 99%

Abnormal dynamic ventilation function of COVID-19 survivors detected by pulmonary free-breathing proton MRI

Wang

Xiao

et al. 2022

Eur Radiol

Self Cite

View full text Add to dashboard Cite

show abstract

“…A, The dose equivalent volume delivered to the subject was 55 mL (0.6 L of natural abundance 129 Xe polarized to 35%) and the SNR is 22. B, The dose equivalent volume delivered to the subject was 100 mL (0.38 L of enriched 129 Xe polarized to 33%) and the SNR is 39 achieved via compressed sensing techniques 106 -enables both ventilation and 1 H anatomical images to be acquired within the same breath, thereby improving image registration and quantitative analysis. 107 3D imaging has several potential advantages, including improved SNR and spatial contiguity of data, 108 but is more prone to motion artifacts from respiratory and cardiac motion.…”

Section: Ventilation Imagingmentioning

confidence: 99%

“…“Stack of spirals” imaging has enabled full lung coverage in 1‐2 s, 98,103‐105 which mitigates concerns of subjects exhaling early, particularly in those with severe lung disease. Furthermore, such rapid encoding–which can also be achieved via compressed sensing techniques 106 —enables both ventilation and 1 H anatomical images to be acquired within the same breath, thereby improving image registration and quantitative analysis 107 . 3D imaging has several potential advantages, including improved SNR and spatial contiguity of data, 108 but is more prone to motion artifacts from respiratory and cardiac motion.…”

Section: Challenges and Areas For Developmentmentioning

confidence: 99%

Protocols for multi‐site trials using hyperpolarized ¹²⁹Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the ¹²⁹Xe MRI clinical trials consortium

Niedbalski

Hall

Castro

et al. 2021

Magnetic Resonance in Med

View full text Add to dashboard Cite

Hyperpolarized (HP) 129Xe MRI uniquely images pulmonary ventilation, gas exchange, and terminal airway morphology rapidly and safely, providing novel information not possible using conventional imaging modalities or pulmonary function tests. As such, there is mounting interest in expanding the use of biomarkers derived from HP 129Xe MRI as outcome measures in multi‐site clinical trials across a range of pulmonary disorders. Until recently, HP 129Xe MRI techniques have been developed largely independently at a limited number of academic centers, without harmonizing acquisition strategies. To promote uniformity and adoption of HP 129Xe MRI more widely in translational research, multi‐site trials, and ultimately clinical practice, this position paper from the 129Xe MRI Clinical Trials Consortium (https://cpir.cchmc.org/XeMRICTC) recommends standard protocols to harmonize methods for image acquisition in HP 129Xe MRI. Recommendations are described for the most common HP gas MRI techniques—calibration, ventilation, alveolar‐airspace size, and gas exchange—across MRI scanner manufacturers most used for this application. Moreover, recommendations are described for 129Xe dose volumes and breath‐hold standardization to further foster consistency of imaging studies. The intention is that sites with HP 129Xe MRI capabilities can readily implement these methods to obtain consistent high‐quality images that provide regional insight into lung structure and function. While this document represents consensus at a snapshot in time, a roadmap for technical developments is provided that will further increase image quality and efficiency. These standardized dosing and imaging protocols will facilitate the wider adoption of HP 129Xe MRI for multi‐site pulmonary research.

show abstract

“…conventional MRI) (10,29). Therefore, the optimum use of the strong hyperpolarized MR signal benefits using dedicated image acquisition strategies including the rapid k-space sampling, and fewer RF pulses (14,(30)(31)(32)(33)(34).…”

Section: Hyperpolarizedmentioning

confidence: 99%

Computational investigation of fitting for calculation of signal dynamics from hyperpolarized xenon-129 Gas MRI

DOĞANAY

2022

Ege Tıp Dergisi

View full text Add to dashboard Cite

Aim: Computational fitting methods were investigated to determine the most accurate fitting approach for the calculation of dynamic hyperpolarized MRI parameters. Materials and Methods: The signal decay of a time-series Hyperpolarized xenon gas MRI phantom was fitted to Bloch equations using three methods varying the fitting parameters for calculation of flip angle, α, and longitudinal relaxation time, T 1 . The first fitting method used an initial calculation of α before the fitting process. The second and third techniques used direct fitting of signal decay equations with and without upper-lower boundaries for calculation of α, and T 1 . Wilcoxon signed-rank test was used to investigate the statistical significance of the calculated parameters. Results: The first approach was the most accurate fitting technique that allowed direct calculation of α=8.65° in agreement to the third approach α=8.73±0.78°, 8.75±0.12°, 8.67±0.05°. Additionally, the standard deviation of the calculated T 1 was lower than 1% (T 1 =103.2±0.04s) which was significantly more accurate than the second method (T 1 =90±30.2s and 135.7±10.3s) and the third method (T 1 =101.4±5.1s and 113.5±16.1s). Conclusion:The first technique provides repeatable and reliable calculation of signal decay parameters including α and T 1 from the dynamic hyperpolarized gas MR images and more accurate than direct fitting methods.

show abstract

Highly and Adaptively Undersampling Pattern for Pulmonary Hyperpolarized ¹²⁹Xe Dynamic MRI

Cited by 10 publications

References 40 publications

Abnormal dynamic ventilation function of COVID-19 survivors detected by pulmonary free-breathing proton MRI

Abnormal dynamic ventilation function of COVID-19 survivors detected by pulmonary free-breathing proton MRI

Protocols for multi‐site trials using hyperpolarized ¹²⁹Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the ¹²⁹Xe MRI clinical trials consortium

Computational investigation of fitting for calculation of signal dynamics from hyperpolarized xenon-129 Gas MRI

Contact Info

Product

Resources

About

Highly and Adaptively Undersampling Pattern for Pulmonary Hyperpolarized 129Xe Dynamic MRI

Cited by 10 publications

References 40 publications

Abnormal dynamic ventilation function of COVID-19 survivors detected by pulmonary free-breathing proton MRI

Abnormal dynamic ventilation function of COVID-19 survivors detected by pulmonary free-breathing proton MRI

Protocols for multi‐site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium

Computational investigation of fitting for calculation of signal dynamics from hyperpolarized xenon-129 Gas MRI

Contact Info

Product

Resources

About

Highly and Adaptively Undersampling Pattern for Pulmonary Hyperpolarized ¹²⁹Xe Dynamic MRI

Protocols for multi‐site trials using hyperpolarized ¹²⁹Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the ¹²⁹Xe MRI clinical trials consortium