Highly Active Antiretroviral Therapy is Associated with Decreased Incidence of Sexually Transmitted Diseases in a Taiwanese HIV-Positive Population

Cheng, Shu Hsing; Yang, Chin-Hui; Hsueh, Yu Mei

doi:10.1089/apc.2012.0385

Cited by 7 publications

(10 citation statements)

References 41 publications

(78 reference statements)

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“…[ 11 , 28 ] The clinical role of ART on prevention of STIs other than HIV infection is pondered. Although ART has been associated with a lower incidence of STIs, including syphilis, [ 29 ] the association between ART and repeat syphilis in HIV-infected patients remained controversial. [ 10 , 19 , 30 – 32 ] Our national data demonstrated that retention in HIV care with ART adherence rate of ≥ 85% were associated with a lower risk of repeat syphilis.…”

Section: Discussionmentioning

confidence: 99%

“…[ 34 ] In Taiwan, HIV-infected patients could easily access to free ART since 1997, and since 2007 a national integrated case management program was launched to reduce risky behaviors in AIDS referral hospitals. [ 25 , 29 ] Other than antiviral agents, integration of program of assessment of ART adherence, health education and counseling of STIs prevention were provided by clinician and HIV case manager is important strategy for control of syphilis. [ 25 , 26 ] Previous studies have demonstrated that risky behaviors among HIV-infected patients will decrease when linked to and retained in primary care [ 35 ] and with clinician-delivered intervention.…”

Section: Discussionmentioning

confidence: 99%

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Increased repeat syphilis among HIV-infected patients

et al. 2020

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Among human immunodeficiency virus (HIV)–infected individuals, syphilis is an important sexually transmitted infection (STI), and repeat infections are common. Identifying risk factors for delineating the trends in repeat syphilis are essential for STI and HIV prevention. This study is to investigate the dynamic of the syphilis epidemic among HIV-infected patients and to identify the risk factors associated with repeat syphilis. A population-based cohort design was used to analyze claim data between January 2000 and December 2010 using the Taiwan National Health Insurance Research Database. The Poisson regression test was used to identify risk factors for repeat syphilis. Of 13,239 HIV-infected patients, annual syphilis screen tests have been performed in 4,907 (37.1%) of these patients. Syphilis has been diagnosed in 956 (19.5%) patients, and 524 (10.7%) had repeat syphilis. The annual trend in repeat syphilis showed a significant increase in the study period ( β = 0.23, P < .001). Younger age (adjusted incidence rate ratio [aIRR] 1.43; 95% CI 1.11–1.86), male gender (aIRR 11.14, 95% CI 4.16–29.79), a history of STIs (aIRR 1.39, 95% CI 1.21–1.59) were independently associated with repeat syphilis. The retention in HIV care and adherence to antiretroviral therapy ≥85% ([aIRR] 0.77, 95% CI 0.61–0.98; P < .001) were associated with a reduced risk of repeat syphilis. The incidence of repeat syphilis increased during 11 years of follow-up. The screening of syphilis for early diagnosis and retention in HIV care with medication adherence should be encouraged to minimize the risk of repeat syphilis in the targeted population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Increased repeat syphilis among HIV-infected patients

et al. 2020

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“…4 There are dyadic benefits to early HAART initiation and adherence; viral suppression improves health outcomes and reduces the likelihood of transmission to an HIV-negative person. 6-12 Despite evidence indicating that male same-sex dyads may benefit from improved HAART adherence, no HIV interventions currently exist to address dyadic needs across the care continuum.…”

Section: Introductionmentioning

confidence: 99%

“Working Together to Reach a Goal”

Goldenberg

Clarke

Stephenson

2013

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Introduction Same-sex serodiscordant male dyads represent a high priority risk group, with approximately one to two-thirds of new HIV infections among MSM attributable to main partnerships. Early initiation and adherence to highly active antiretroviral treatment (HAART) is a key factor in HIV prevention and treatment; however, adherence to HAART in the U.S. is low, with poor retention throughout the continuum of care. This study examines MSM's perceptions of dyadic HIV treatment across the continuum of care to understand preferences for how care may be sought with a partner. Methods We conducted five focus group discussions (FGDs) in Atlanta, GA with 35 men who report being in same-sex male partnerships. Participants discussed perceptions of care using scenarios of a hypothetical same-sex male couple who recently received serodiscordant or seroconcordant positive HIV results. Verbatim transcripts were segmented thematically and systematically analyzed to examine patterns in responses within and between participants and FGDs. Results Participants identified the need for comprehensive dyadic care and differences in care for seroconcordant positive versus serodiscordant couples. Participants described a reciprocal relationship between comprehensive dyadic care and positive relationship dynamics. This combination was described as reinforcing commitment, ultimately leading to increased accountability and treatment adherence. Discussion Results indicate that the act of same-sex male couples “working together to reach a goal” may increase retention to HIV care across the continuum if care is comprehensive, focuses on both individual and dyadic needs, and promotes positive relationship dynamics.

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“…14,15 Patients on ART have not only a reduced risk of HIV transmission to their sero-discordant partners, 16,17 but also a reduced risk of acquiring other STDs. 18 A recent study has indicated that home-based interventions can significantly improve the adherence of ART patients. Sustaining a matching scale-up of ART and adherence interventions is necessary in reducing disease burden of HIV infection in the affected populations.…”

Section: Discussionmentioning

confidence: 99%

Shifting Patterns of the HIV Epidemic in Southwest China: A Case Study Based on Sentinel Surveillance, 1995–2012

Chow

Gao

Liang

et al. 2015

AIDS Patient Care and STDs

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The HIV epidemic is experiencing a rapid shift in transmission profile in China. This study aims to examine the changes in magnitude, transmission pattern, and trend of the HIV epidemic in a typical Southwest Chinese prefecture over the period of 1995-2012. HIV surveillance data from the web-based reporting system were analyzed during this period. We investigated the temporal trends in the changing characteristics of HIV transmission, the HIV disease burden in key affected populations, and assessed the impacts on HIV disease progression due to scale-up of antiretroviral treatment. A total of 3556 HIV/AIDS cases were reported in Yuxi prefecture, Yunnan, over the study period. The number of HIV tests conducted has dramatically increased from 1041 in 1995 to 247,859 in 2012, resulting in a substantial increase in HIV diagnoses from 11 cases to 327 cases over the same period. Since 2005, cumulatively 1250 eligible people living with HIV (PLHIV) have received combination antiretroviral therapy which reduced AIDS disease progression from 9.0% (95% CI: 6.7-11.4%) in 1995 to 0.1% (0-0.3%) in 2012 (ptrend=0.0002). The primary mode of HIV transmission has been shifted from injection sharing (71.9% diagnoses in 1995-2004) to unsafe sexual contacts (82.6% diagnoses in 2012). Yuxi prefecture is experiencing a concentrated but shifting HIV epidemic. Scale-up of HIV testing is essential to effective sentinel surveillance and enhancing early diagnosis and treatment in PLHIV.

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Highly Active Antiretroviral Therapy is Associated with Decreased Incidence of Sexually Transmitted Diseases in a Taiwanese HIV-Positive Population

Cited by 7 publications

References 41 publications

Increased repeat syphilis among HIV-infected patients

Increased repeat syphilis among HIV-infected patients

“Working Together to Reach a Goal”

Shifting Patterns of the HIV Epidemic in Southwest China: A Case Study Based on Sentinel Surveillance, 1995–2012

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