Highly Active Antiretroviral Therapy (HAART) and Circulating Markers of Immune Activation: Specific Effect of HAART on Neopterin

Amirayan-Chevillard, Nathalie; Tissot‐Dupont, Hervé; Obadia, Yolande; Gallais, H; Mège, Jean‐Louis; Capo, Christian

doi:10.1128/cdli.7.5.832-834.2000

Cited by 21 publications

(21 citation statements)

References 21 publications

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“…Our results correlate with a study conducted by Amirayan-Chevillard et al which showed that ART significantly decreased the circulating levels of neopterin by about 30% (15.6 ± 1.5 ng/mL for treated versus 22.3 ± 3.7 ng/mL for naïve patients) [12]. For groups B and C subjects, the median level of neopterin at baseline was 22.9 nmol/L and 16.2 nmol/L, respectively, which significantly increased to 37 nmol/L and 27.6 nmol/L at followup, respectively.…”

Section: Discussionsupporting

confidence: 91%

Utility of Serum Neopterin and Serum IL-2 Receptor Levels to Predict Absolute CD4 T Lymphocyte Count in HIV Infected Cases

Chadha

Gautam

Chakravarti

et al. 2013

Interdisciplinary Perspectives on Infectious Diseases

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A prospective study was carried out to evaluate the efficacy of serum neopterin and soluble IL-2 receptor (sIL-2R) concentrations in comparison to CD4 count to study the progression of HIV disease and monitor response to ART in HIV cases. One hundred newly diagnosed HIV seropositive subjects were recruited. CD4 counts were determined by FACS system. Serum neopterin and sIL-2R levels were measured using enzyme immunoassay. In our study, levels of neopterin and sIL-2R were significantly higher in subjects with CD4 <200 cells/ L (with S. neopterin levels of >25.1 nmol/L and sIL-2R levels of >47.1 pM as cutoff values for CD4 <200 cells/ L) compared to those in subjects with CD4 >200 cells/ L at baseline which indicate that these markers can be utilized for initiation of ART in HIV cases. The levels of these markers decreased significantly after initiation of ART. In patients with CD4 >200 cells/ L, these markers are helpful in predicting disease progression.

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Section: Discussionsupporting

confidence: 91%

Utility of Serum Neopterin and Serum IL-2 Receptor Levels to Predict Absolute CD4 T Lymphocyte Count in HIV Infected Cases

Chadha

Gautam

Chakravarti

et al. 2013

Interdisciplinary Perspectives on Infectious Diseases

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“…2,3,5,33 For example, in Austria, additional testing of neopterin among blood donors was made mandatory since 1986, such that between 1986 and 2002, nearly 900 000 voluntary blood donations were screened as part of routine practice with commercially available assays that used a cut point of 10 nmol/L to define an abnormal result. 34 Importantly, in the present large cohort, the intraclass correlation between neopterin at 7 days after ACS and at 2 years was 0.6, which was comparable to the long-term intraindividual variance in both hsCRP and LDL-C. 13 This suggests that neopterin levels are relatively stable in any given individual over time.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Prognostic Value of Neopterin

et al. 2007

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Background-Monocyte activation is believed to play an important role in the pathogenesis of acute coronary syndromes (ACS). Neopterin is a soluble marker of monocyte activation, and elevated levels are of prognostic value in patients with stable coronary artery disease. Methods and Results-Neopterin levels were measured on average at 7 days (in 3946 patients) and at 4 months (in 3369 patients) after ACS in the PRavastatin Or atorVastatin Evaluation Infection Therapy-Thrombolysis In Myocardial Infarction (PROVE IT-TIMI 22) trial. We assessed the relationship between plasma neopterin levels and the risk of death and death or acute coronary events (nonfatal myocardial infarction or unstable angina) over 2 years. Seven days after an ACS event, neopterin levels Ն12.11 nmol/L (upper quartile, derived from a post hoc analysis) were associated with an increased risk of death and an increased risk of death or acute coronary events after adjustment for age, gender, history of diabetes mellitus, history of hypertension, history of smoking, type of ACS presentation, use of percutaneous coronary intervention for the index event, statin regimen, low-density lipoprotein cholesterol, and high-sensitivity C-reactive protein (hazard ratio,

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“…Plasma galectin-9 (GAL-9), which binds to T-cell immunoglobulin domain and mucin domain 3 (TIM-3), negatively regulates IFN-γ secretion and influences the ability to induce T cell tolerance in both mice and man, was also studied (Anderson 2007;Anderson et al 2007). We also measured neopterin, which is known to be increased in AIDS patients and decreased after HAART (Amirayan-Chevillard et al 2000) along with other conventional inflammatory markers such as endotoxin and procalcitonin in this study.…”

Section: Tohoku University Medical Pressmentioning

confidence: 99%

Persistent Elevation of Plasma Osteopontin Levels in HIV Patients Despite Highly Active Antiretroviral Therapy

Chagan-Yasutan

Saitoh

Ashino

et al. 2009

Tohoku J. Exp. Med.

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Highly Active Antiretroviral Therapy (HAART) and Circulating Markers of Immune Activation: Specific Effect of HAART on Neopterin

Cited by 21 publications

References 21 publications

Utility of Serum Neopterin and Serum IL-2 Receptor Levels to Predict Absolute CD4 T Lymphocyte Count in HIV Infected Cases

Utility of Serum Neopterin and Serum IL-2 Receptor Levels to Predict Absolute CD4 T Lymphocyte Count in HIV Infected Cases

Long-Term Prognostic Value of Neopterin

Persistent Elevation of Plasma Osteopontin Levels in HIV Patients Despite Highly Active Antiretroviral Therapy

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