Highly Active Antiretroviral Therapy–Associated Flare of Oropharyngeal Kaposi Sarcoma

Naidu, Tesuven K.; Ramdial, Pratistadevi K.; Naidoo, Shamlan K.

doi:10.1001/archoto.2012.1343

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…After implementation of cART, practitioners should be especially aware of potentially lethal KS flares as a result of immune reconstitution inflammatory syndrome (IRIS). 17 These cannot accurately be predicted and one should be prepared to undertake appropriate life-supporting measures as soon as any signs and symptoms of IRIS have been recognized. 18 This patient demonstrated an increase in enoral tumorous lesions with the introduction of cART, however, oral KS lesion flare with further airway compromise was avoided by electrosurgical tumor debulking in general anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Oral Kaposi’s Sarcoma: A Case Report and Literature Review on Treatment Management

Thieringer

Cede

Glatz

et al. 2021

Craniomaxillofacial Trauma & Reconstruction Open

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Background: Kaposi’s sarcoma is a common malignancy in HIV patients. Oral manifestation of AIDS-associated Kaposi’s sarcoma occurs in up to 65% of HIV/AIDS patients and is a poor prognostic factor. We report the case of a patient with a progressive bulky manifestation of oral Kaposi’s sarcoma. Case Presentation: A 48-year-old male presented with dysphagia due to progressive indolent swelling of the palate. Intraoral inspection revealed an uneven, partially ulcerated, livid mass, approximately 5 cm in diameter, extending antero-posteriorly from the superior vestibulum to the soft palate and across the hard palate, thereby overgrowing remaining teeth and the alveolar arch. Serological testing revealed an HIV infection, and further tests showed HHV8-positivity. The patient underwent surgical debulking of the oral lesions and, following complete remission, received full mouth reconstruction with an implant-supported prosthesis. Conclusions: Understanding the relation of HIV and HHV8-infection in terms of disease onset and clinical presentation is important to increase awareness of oral Kaposi’s sarcoma and ensure subsequent appropriate management of affected patients. Clinical staging represents the most important factor for choosing the optimal treatment. The introduction of combined antiretroviral therapy has proven to be efficient in curing oral Kaposi’s sarcoma, while several additional locoregional treatment options, including debulking surgery, may be necessary for symptom relief or to improve cosmesis. Radiotherapy should be applied restrictively due to potentially severe toxic mucosal reactions, whereas additional chemotherapy must be considered in severe cases that present with widespread disseminated disease. A multidisciplinary approach to the treatment of functionally and aesthetically impairing oral Kaposi’s sarcoma is highly recommended.

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Section: Discussionmentioning

confidence: 99%

Oral Kaposi’s Sarcoma: A Case Report and Literature Review on Treatment Management

Thieringer

Cede

Glatz

et al. 2021

Craniomaxillofacial Trauma & Reconstruction Open

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“…Campanini et al in their retrospective study on 470 HIV-positive patients treated with HAART showed a reduction cancer probability (i.e., from 3% to 0%) [ 22 ]. Despite those positive effects, adverse clinical events can occur; in particular, the immune reconstitution inflammatory syndrome (IRIS), characterized by an exuberant immune-mediated inflammatory response, can increase the treatment-related morbidity [ 23 ]. It can allow the recurrence of previously treated opportunistic infections and/or neoplasm [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Isolated Kaposi Sarcoma of the Tonsil: A Case Report and Review of the Scientific Literature

Pittore

Pelagatti

Deiana

et al. 2015

Case Reports in Otolaryngology

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Kaposi sarcoma is a tumour caused by human herpes virus 8, also known as Kaposi sarcoma-associated herpes virus. It usually affects the skin and oral mucosa; however, it can also sometimes affect the lungs, the liver, the stomach, the bowel, and lymph nodes. Several body sites may be affected simultaneously. The involvement of the tonsils is rare. We described an isolated localization of Kaposi's sarcoma of the right tonsil in a HIV-positive patient.

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“…However, remission can be achieved after considerable time, ranging from months to years . Delayed clinical responses are particularly undesirable in patients who have upper respiratory tract lesions at risk of ulceration, bleeding, dysphonia, dysphagia, or dyspnea . Chemotherapy or other local therapies (e.g., radiotherapy, sclerotherapy, vinblastine) have shown to be effective, but they may induce significant toxicities.…”

Section: Discussionmentioning

confidence: 99%

“…7 Delayed clinical responses are particularly undesirable in patients who have upper respiratory tract lesions at risk of ulceration, bleeding, dysphonia, dysphagia, or dyspnea. 6,16 Chemotherapy or other local therapies (e.g., radiotherapy, sclerotherapy, vinblastine) 5,17,18 have shown to be effective, but they may induce significant toxicities. Therefore, we explored whether local administration of BVZ would be a safe and efficient treatment for KS lesions of the upper airway.…”

Section: Discussionmentioning

confidence: 99%

Intralesional bevacizumab in patients with Human immunodeficiency virus–associated Kaposi's sarcoma in the upper airway

Ablanedo-Terrazas¹,

Barrera²,

Ormsby³

et al. 2014

The Laryngoscope

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Highly Active Antiretroviral Therapy–Associated Flare of Oropharyngeal Kaposi Sarcoma

Cited by 3 publications

References 15 publications

Oral Kaposi’s Sarcoma: A Case Report and Literature Review on Treatment Management

Oral Kaposi’s Sarcoma: A Case Report and Literature Review on Treatment Management

Isolated Kaposi Sarcoma of the Tonsil: A Case Report and Review of the Scientific Literature

Intralesional bevacizumab in patients with Human immunodeficiency virus–associated Kaposi's sarcoma in the upper airway

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