Highly active antimycobacterial derivatives of benzoxazine

Petrlikova, Eva; Waisser, Karel; Divišová, Hana; Husáková, Petra; Vrabcová, Petra; Kuneš, Jiřı́; Kolář, Karel; Stolaříková, Jiřina

doi:10.1016/j.bmc.2010.10.017

Cited by 35 publications

(7 citation statements)

References 14 publications

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“…Dihydro-1,3-oxazine derivatives are important heterocyclic molecules, which exhibit a wide range of pharmacological activity, including antibacterial, [10] fungicidal, [11] antitumor, [12] antituberculosis, [13] and anti-HIV. [14] Naphthoxazine derivatives have therapeutic potential for the treatment of Parkinsons disease, and are also used as potent nonsteroidal progesterone receptor agonists.…”

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confidence: 99%

Copper‐Catalyzed Regioselective Intramolecular Oxidative α‐Functionalization of Tertiary Amines: An Efficient Synthesis of Dihydro‐1,3‐Oxazines

et al. 2013

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confidence: 99%

Copper‐Catalyzed Regioselective Intramolecular Oxidative α‐Functionalization of Tertiary Amines: An Efficient Synthesis of Dihydro‐1,3‐Oxazines

et al. 2013

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“…Further, the antimycobacterial activity increased with the replacement of the carbonyl group by the thiocarbonyl group in the starting 3-(4-alkylphenyl) -2H-1,3-benzoxazine-2,4 (3H) -diones. 138,139…”

Section: Anti-tuberculosis Activitymentioning

confidence: 99%

3,4-Dihydro-2H-1,3-benzoxazines and their oxo-derivatives - Chemistry and bioactivities

Eldin

2021

JSCS

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It must be stressed that the manuscript still has to be subjected to copyediting, typesetting, English grammar and syntax corrections, professional editing and authors' review of the galley proof before it is published in its final form. Please note that during these publishing processes, many errors may emerge which could affect the final content of the manuscript and all legal disclaimers applied according to the policies of the Journal.

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“…3,4-dihydro-2 H -1,3-benzoxazines exhibit a wide range of biological activity [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ], such as bactericidal, fungicidal, antitumour, antituberculosis, and anthelmintic effects, therefore, the synthesis of these compounds has attracted great interest. Several elegant methods for the preparation of these compounds have been documented in the literature [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines

et al. 2012

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A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, 1H-NMR, 13C-NMR, MS and elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated, and some compounds exhibited good activity against Rhizoctonia solani.

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Highly active antimycobacterial derivatives of benzoxazine

Cited by 35 publications

References 14 publications

Copper‐Catalyzed Regioselective Intramolecular Oxidative α‐Functionalization of Tertiary Amines: An Efficient Synthesis of Dihydro‐1,3‐Oxazines

Copper‐Catalyzed Regioselective Intramolecular Oxidative α‐Functionalization of Tertiary Amines: An Efficient Synthesis of Dihydro‐1,3‐Oxazines

3,4-Dihydro-2H-1,3-benzoxazines and their oxo-derivatives - Chemistry and bioactivities

Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines

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