Highlights of the annual meeting of the European Association of Nuclear Medicine, Lausanne 1993

Britton, K. E.

doi:10.1007/bf00175765

Cited by 7 publications

(1 citation statement)

References 14 publications

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“…Better use of the biochemical and cell biological information content of radioisotope scans will be made. Professor Britton, in his summing up of the 1993 European Association of Nuclear Medicine Annual Congress [ 11 ], detected a trend from function/blood flow measurement towards tissue characterisation, and from sensitivity towards specificity. He argued that this shift in emphasis is a desirable goal for the 1990s, and achieving it will require improved understanding of the biochemical behaviour and targeting mechanisms of radiopharmaceuticals.…”

Section: Introductionmentioning

confidence: 97%

Radionuclide targeting and dosimetry at the microscopic level: the role of microautoradiography

Puncher

Blower

1994

Eur J Nucl Med

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The understanding of localisation mechanisms and microdosimetry of diagnostic and therapeutic radiopharmaceuticals depends on knowledge of their biodistribution at the microscopic level (cellular and subcellular) in the target tissues. Various methods have been advanced for obtaining information about this microdistribution: subcellular fractionation, secondary ion mass spectrometry imaging, microprobe elemental analysis in the electron microscope, and microautoradiography. This review compares these approaches, and discusses in detail the methodology of microautoradiography (the most generally useful approach) with imaging and therapy radionuclides. Literature examples of applications of microautoradiography in nuclear medicine are reviewed, and the future potential contribution of the techniques is assessed.

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Section: Introductionmentioning

confidence: 97%

Radionuclide targeting and dosimetry at the microscopic level: the role of microautoradiography

Puncher

Blower

1994

Eur J Nucl Med

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The Tissue Characterisation of Malignancy with Radionuclide Studies

Britton

1995

Radioactive Isotopes in Clinical Medicine and Research

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Radiolabelled monoclonal antibodies in tumour imaging and therapy: out of fashion?

Delaloye

1995

Eur J Nucl Med

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The initial enthusiasm for the development of diagnostic and therapeutic studies involving the use of monoclonal antibodies was replaced by scepticism as hopes remained unfulfilled. Against this background one needs to ask whether immunoscintigraphy (IS) serves clinical needs effectively and whether radioimmunotherapy (RIT) has a future. The current review considers these questions by reference to relevant studies. Taking colorectal cancer as an example, an appraisal is offered of the ability of IS to detect disease at an early stage and thereby to reduce mortality, and of the influence of the results of IS on patient management. It is concluded that in a limited number of cases of colorectal cancer and other solid tumors, IS will allow surgery to be performed at a stage where cure is still possible because of its ability to detect early recurrence. Turning to RIT, the results of studies in respect of various tumour types are reviewed, with due attention to reported toxicity. As regards colorectal cancer, no consistent therapeutic effects have been achieved, and myelotoxicity is typically the dose-limiting factor. Thus many questions remain to be answered, regarding antigens to be targeted, fractionation schedule, the use of "humanised" antibodies, choice of radionuclide and the use of intact immunoglobulins or fragments. These questions are considered. Overall it is concluded that the most promising application of RIT is as adjuvant therapy in patients with minimal residual disease, and a controlled multicentre trial is recommended. The development of more potent radio-immunoconjugates for therapeutic and ultimately diagnostic purposes will contribute to the improvement and development of IS by increasing its potential to influence prognosis.

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Highlights of the annual meeting of the European Association of Nuclear Medicine, Lausanne 1993

Cited by 7 publications

References 14 publications

Radionuclide targeting and dosimetry at the microscopic level: the role of microautoradiography

Radionuclide targeting and dosimetry at the microscopic level: the role of microautoradiography

The Tissue Characterisation of Malignancy with Radionuclide Studies

Radiolabelled monoclonal antibodies in tumour imaging and therapy: out of fashion?

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