Highlights from the Latest Articles in Advanced Biomanufacturing at Micro- and Nano-Scale

Assal, Rami El; Chen, Pu; Demirci, Utkan

doi:10.2217/nnm.14.210

Cited by 22 publications

(2 citation statements)

References 14 publications

(11 reference statements)

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“…Following rewarming, the biopreserved cells maintained their unique morphology, mechanics, and function. The bio-inspired bioprinting approach has the potential to create new avenues to biopreserve cells (e.g., stem cells, lymphocytes, and oocytes) for regenerative and reproductive medicine applications [7,68,174].…”

Section: Biopreservationmentioning

confidence: 99%

“…Analogously, bioprinting can potentially enable a high-throughput and affordable tool to assemble cells, enabling complex tissue constructs to become broadly available to many researchers and scientists [2][3][4]. Bioprinting is the process of patterning biological materials (e.g., cells, biomaterials, and biomolecules) to fabricate tissuemimicking constructs using advanced additive manufacturing technologies [5][6][7][8]. During the bioprinting process, biocompatible materials (i.e., bio-inks) are used to facilitate the printing and act as matrices (i.e., bio-papers) for printed cells [5,9,10], which can then be grown in perfusion vessels (i.e., bioreactors) for further cellular and functional maturation.…”

Section: Introductionmentioning

confidence: 99%

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Towards artificial tissue models: past, present, and future of 3D bioprinting

Arslan‐Yildiz¹,

Assal²,

Chen³

et al. 2016

Biofabrication

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243

175

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Regenerative medicine and tissue engineering have seen unprecedented growth in the past decade, driving the field of artificial tissue models towards a revolution in future medicine. Major progress has been achieved through the development of innovative biomanufacturing strategies to pattern and assemble cells and extracellular matrix (ECM) in three-dimensions (3D) to create functional tissue constructs. Bioprinting has emerged as a promising 3D biomanufacturing technology, enabling precise control over spatial and temporal distribution of cells and ECM. Bioprinting technology can be used to engineer artificial tissues and organs by producing scaffolds with controlled spatial heterogeneity of physical properties, cellular composition, and ECM organization. This innovative approach is increasingly utilized in biomedicine, and has potential to create artificial functional constructs for drug screening and toxicology research, as well as tissue and organ transplantation. Herein, we review the recent advances in bioprinting technologies and discuss current markets, approaches, and biomedical applications. We also present current challenges and provide future directions for bioprinting research.

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Section: Biopreservationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Towards artificial tissue models: past, present, and future of 3D bioprinting

Arslan‐Yildiz¹,

Assal²,

Chen³

et al. 2016

Biofabrication

Self Cite

243

175

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Light‐Responsive Nanoassemblies: Advancing Biomedical Innovation

Sia,

Tey,

Low

2024

Adv Funct Materials

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The integrative use of light and nanoassemblies has made a profound impact in the biomedical field for diagnosis, drug delivery, and phototherapy. Recent advances in the development of light‐responsive nanoassemblies showcase their capabilities in facilitating targeted diagnosis and therapy with minimal invasiveness, shaping the future of personalized medicine. In this work, the fundamental differences between types of light in biomedical applications, and the application of light‐responsive nanoassemblies in diagnosis and therapy are described, their biosafety profile is overviewed and discussed, and the translational challenges and potential clinical outlook of this emerging field are outlined.

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Zinc pthalocyanine‐loaded chitosan/mPEG‐PLA nanoparticles‐mediated photodynamic therapy for the treatment of cutaneous squamous cell carcinoma

Keyal

Luo

Bhatta

et al. 2018

Journal of Biophotonics

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Zinc pthalocyanine (ZnPc) is a second-generation photodynamic therapy (PDT) sensitizer with sufficient PDT activity for squamous cell carcinoma (SCC). ZnPc is hydrophobic and insoluble in water, which creates hurdles in systemic administration and hence restricts its use in clinic. Here we have loaded ZnPc on chitosan/methoxy polyethylene glycol-polylactic acid (CPP) nanoparticles to form Z-CPP to enhance PDT efficacy. In vitro and in vivo studies were performed to see dark toxicity of the compounds ZnPc, CPP and Z-CPP. Then PDT was done and its growth inhibitory effect on SCC cells was evaluated. In addition, reactive oxygen species (ROS) formation and apoptosis of cancer cells following PDT were studied. The results showed that the tested compounds exhibit no dark toxicity and the effect of PDT was significantly better with Z-CPP when compared to free ZnPc (P < .05). Photoactivation of Z-CPP led to a dose-dependent growth inhibition of cancer cells of >50% at 1 μM to >80% at 10 μM concentration. Also Z-CPP-treated cells had highest number of apoptotic cells and produced more ROS compared to free ZnPc-treated cells (P < .05). Hence, this study suggests that Z-CPP is a suitable pharmaceutical compound to increase PDT efficacy.

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Highlights from the Latest Articles in Advanced Biomanufacturing at Micro- and Nano-Scale

Cited by 22 publications

References 14 publications

Towards artificial tissue models: past, present, and future of 3D bioprinting

Towards artificial tissue models: past, present, and future of 3D bioprinting

Light‐Responsive Nanoassemblies: Advancing Biomedical Innovation

Zinc pthalocyanine‐loaded chitosan/mPEG‐PLA nanoparticles‐mediated photodynamic therapy for the treatment of cutaneous squamous cell carcinoma

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