Highlight report: acetaminophen hepatotoxicity

Highlight report: Metabolomics in hepatotoxicity testing

“…Currently, mechanisms of hepatotoxicity represent a major focus in toxicological research (Kyriakides et al, 2016[ 18 ]; Ghallab, 2015[ 7 ]; Ramachandran et al, 2015[ 19 ]; Chen et al, 2015[ 4 ]; Campos et al, 2014[ 3 ]; Hammad et al, 2014[ 14 ]; Hassan, 2016[ 15 ]; Stöber, 2015[ 23 ]). Despite progress in the field of stem cell research (Gómez-Lechón and Tolosa, 2016[ 12 ]; Godoy et al, 2016[ 11 ]; Cameron et al, 2015[ 2 ]) and studies with cell lines (Tolosa et al, 2015[ 25 ]; Hewitt et al, 2007[ 16 ]; Godoy et al, 2013[ 10 ]), primary hepatocytes still remain a gold standard (Reif et al, 2015[ 22 ]; Grinberg et al, 2014[ 13 ]; Stöber, 2015[ 23 ]; Ghallab, 2015[ 6 ]; Arbo et al, 2016[ 1 ]). Moreover PBPK modeling (Ghallab, 2015[ 8 ]; Reif et al, 2017[ 21 ]; Thiel et al, 2015[ 24 ]) and spatio-temporal models (Ghallab et al, 2016[ 9 ]; Vartak et al, 2016[ 26 ]; Jansen et al, 2017[ 17 ]; Friebel et al, 2015[ 5 ]) have supported our understanding of the mechanisms of liver toxicity.…”

Highlight report: physiologically-based modeling of diseased liver tissue

“…For this purpose, Schenk et al (2017) time-dependently analyzed the concentrations of a set of drugs (midazolam, torsemide, codein, talinolol, pravastatin and caffeine) in the portal vein and liver vein of mice and compared the situation in healthy mice and after CCl 4 intoxication. The mechanisms of hepatotoxicity and their functional consequences are currently an intensively studied field of research (Kyriakides et al 2016;Ghallab 2015;Mazzanti et al 2015;Tolosa et al 2015;Stöber 2016;Stoeber 2015a, b;Hammad 2013;El-Zawahry et al 2016). The modeling techniques presented by Schenk et al may certainly help to better understand the relationship between structural loss of tissue and its consequences on the function.…”