Higher visceral adiposity index was associated with an elevated prevalence of gallstones and an earlier age at first gallstone surgery in US adults: the results are based on a cross-sectional study

Zhang, Gaopeng; Ding, Zhewen; Yang, Junping; Wang, Tianqi; Li, Tong; Cheng, Jian; Zhang, Chao

doi:10.3389/fendo.2023.1189553

Cited by 7 publications

(8 citation statements)

References 38 publications

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“…The present data align well with past reports of strong positive relationships between DII, which serves as a comprehensive index for dietary inflammation, and gallstone incidence. Higher DII values are also related to the incidence of metabolic syndrome ( 34 ), obesity ( 35 ), and insulin resistance ( 36 ), all of which have the potential to directly or indirectly influence gallstone incidence ( 1 , 34 , 37 ), consistent with the positive relationship noted between DII and gallstones.…”

Section: Discussionsupporting

confidence: 60%

Characterizing the relationships between dietary indices, gallstone prevalence and the need for gallbladder surgery in the general US population

Jiang,

Shao

2024

Front. Nutr.

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BackgroundThe dietary inflammatory index (DII) and composite dietary antioxidant index (CDAI) were developed as tools for use when seeking to assess the potential inflammatory and antioxidant activity of a given diet, respectively. The associations between these indices and gallstone incidence remain largely unexplored.ObjectiveThe present study sought to clarify how both the DII and the CDAI are related to gallstone incidence and age at first gallbladder surgery among adults in the USA.MethodsCross-sectional data from the 2017–2020 cycles of the National Health and Nutrition Examination Survey (NHANES) pertaining to 12,426 individuals were used to conduct the present study. Data from 2 days with 24-h dietary recall were employed when calculating DII and CDAI scores. Relationships between dietary indices and the incidence of gallstones were assessed through logistic regression analyses, while linear regression analyses were employed to characterize how these indices are associated with the age at first gallbladder surgery.ResultsHigher DII scores and lower CDAI scores, which, respectively, denote diets with greater inflammatory potential and reduced antioxidant potential, were found to be associated with higher gallstone incidence even following adjustment for potential confounding factors. Smooth curve fitting suggested that the association between DII and gallstones was nearly linear, whereas that between CDAI and gallstone incidence was nonlinear. Higher DII values were also related to first gallbladder surgery at an earlier age (β = −0.64, 95% CI: −1.26, −0.02).ConclusionThese results emphasize the benefits of anti-inflammatory diets rich in antioxidants, which may help reduce gallstone incidence among adults in the USA. Higher DII scores may also predict the need for gallbladder surgery at a younger age.

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Section: Discussionsupporting

confidence: 60%

Characterizing the relationships between dietary indices, gallstone prevalence and the need for gallbladder surgery in the general US population

Jiang,

Shao

2024

Front. Nutr.

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“…In contrast, a negative linear correlation was found between the METS-IR index and the age at which the first gallstone was formed. In another crosssectional investigation conducted by Zhang et al, 26 a significant discovery was made indicating a positive correlation between a higher visceral obesity index (VAI) and the prevalence of gallstones, potentially resulting in an earlier age at initial gallstone surgery. This association persisted when subgroup analyses were performed in different age groups, and races, with and without hypertension, and with and without diabetes.…”

Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus Mediates the Relationship Between Atherogenic Index of Plasma and Gallstones: A Population-Based Cross-Sectional Study

Du,

Wang,

Song

et al. 2024

DMSO

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Purpose Previous studies have shown a correlation between diabetes mellitus and gallstone formation. The atherogenic index of plasma (AIP) is associated with many metabolic diseases. However, insufficient evidence still exists to elucidate the association between AIP and gallstones. The primary objective of this study was to investigate the correlation between AIP and gallstones in US adults, and the secondary objective was to analyze whether diabetes plays a mediating role in the association. Patients and Methods Using data from the National Health and Nutrition Survey (NHANES) conducted between 2017 and March 2020, this study investigated the association between AIP and gallstone incidence in US adults. A variety of statistical methods were used to analyze the data in this study, including multivariate logistic regression, subgroup analyses, restricted cubic spline curves (RCS), and mediation effects analysis. In addition, two-stage linear regression was used to detect possible threshold and saturation effects. Results A total of 6952 subjects were enrolled in the trial, of which 748 patients were diagnosed with gallstones. A significant positive association between AIP and gallstones was observed by fully adjusted multivariate logistic regression analysis, with an odds ratio (OR) of 1.45 and a 95% confidence interval (CI) of (1.09, 1.93). In addition, a non-linear positive association and saturation effect between AIP and gallstones were found, with an inflection point of 0.2246. Mediation analysis showed that diabetes had a mediating effect of 16.9% in the association between AIP and gallstones. Conclusion This study suggests that elevated levels of AIP are linked to an augmented vulnerability to gallstone development, with diabetes serving as a mediating factor. These findings present a novel perspective on clinical approaches to prevent and manage gallstones.

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“…This study included an assortment of covariates based on the literature (1,2,12,15), such as age, sex (male, female), household poverty-to-income ratio (PIR), educational level (below high school, high school, and above), smoking history (never, former, current), body mass index (BMI), cholesterol level (mg/dl), diabetes and cardiovascular disease (CVD), and dietary intake factors Between 2017 and 2020, every person performed a 24 h dietary recall; our analyses used the initial recall rate. BMI was divided into two categories: nonobese (<25 kg/m 2 ) and obese (≥25 kg/m 2 ).…”

Section: Assessment Of Covariatesmentioning

confidence: 99%

“…Gallstone disease is one of the most common digestive disorders and a significant factor in gastrointestinal hospitalization (1,2). Gallstones are more frequently found in geriatric people and in women than in young people and men (3).…”

Section: Introductionmentioning

confidence: 99%

“…Gallstones are solid biliary conglomerates consisting of calcium bilirubinate, mucus, cholesterol monohydrate crystals, and protein aggregates and can be categorized into cholesterol gallstones and pigment gallstones, with the former accounting for more than 70% of all gallstones (5,11). Age, female, race/genetics, pregnancy, family history of gallstones, and sedentary lifestyle are a few well-known risk factors for gallstones (1,(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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Higher levels of systemic immune-inflammatory index are associated with the prevalence of gallstones in people under 50 years of age in the United States: a cross-sectional analysis based on NHANES

Meng,

Liu

2024

Front. Med.

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IntroductionInflammation plays a significant role in gallstones formation. The prognosis of various illnesses was initially predicted using the systemic immune-inflammatory index (SII). We performed an updated analysis on the impact of SII and gallstones.MethodsTo investigate the connection between the SII and gallstones occurrence in a sample of individuals from the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2020, we employed logistic regression analysis, subgroup analysis, and smoothing curve fitting.ResultsIn our study, an aggregate of 4,950 individuals over the age of 20 were enrolled, and 429 of them claimed to have gallstones. A fully adjusted model showed that the third and fourth quartiles of SII was parallel associated with gallstones in adults (OR = 2.43, 95% CI = 1.39–4.26; OR = 2.97, 95% CI = 1.72–5.16) under 50 years. Subgroup analysis and smoothed curve fitting provided evidence in favor of this finding.ConclusionAccording to our research, gallstones are more likely to occur in US adults younger than 50 years.

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Higher visceral adiposity index was associated with an elevated prevalence of gallstones and an earlier age at first gallstone surgery in US adults: the results are based on a cross-sectional study

Cited by 7 publications

References 38 publications

Characterizing the relationships between dietary indices, gallstone prevalence and the need for gallbladder surgery in the general US population

Characterizing the relationships between dietary indices, gallstone prevalence and the need for gallbladder surgery in the general US population

Diabetes Mellitus Mediates the Relationship Between Atherogenic Index of Plasma and Gallstones: A Population-Based Cross-Sectional Study

Higher levels of systemic immune-inflammatory index are associated with the prevalence of gallstones in people under 50 years of age in the United States: a cross-sectional analysis based on NHANES

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