Higher skin autofluorescence detection using AGE-Reader™ technology as a measure of increased tissue accumulation of advanced glycation end products in dialysis patients with diabetes: a meta-analysis

Varikasuvu, Seshadri Reddy; Aloori, Sowjanya; Bhongir, Aparna Varma

doi:10.1007/s10047-020-01189-6

Cited by 3 publications

(3 citation statements)

References 44 publications

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“…More recently, it has been demonstrated that SAFin a healthy population is directly associated with age, smoking, waist circumference and diet 51 . In disease states associated with increased ROS production, there is a significant increase in skin AGE autofluorescence 52 …”

Section: Hazards Of Advanced Glycation End‐productsmentioning

confidence: 99%

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The effects of advanced glycation end‐products on skin and potential anti‐glycation strategies

Wang,

Jiang,

Zhao

2024

Experimental Dermatology

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The advanced glycation end‐products (AGEs) are produced through non‐enzymatic glycation between reducing sugars and free amino groups, such as proteins, lipids or nucleic acids. AGEs can enter the body through daily dietary intake and can also be generated internally via normal metabolism and external stimuli. AGEs bind to cell surface receptors for AGEs, triggering oxidative stress and inflammation responses that lead to skin ageing and various diseases. Evidence shows that AGEs contribute to skin dysfunction and ageing. This review introduces the basic information, the sources, the metabolism and absorption of AGEs. We also summarise the detrimental mechanisms of AGEs to skin ageing and other chronic diseases. For the potential strategies for counteracting AGEs to skin and other organs, we summarised the pathways that could be utilised to resist glycation. Chemical and natural‐derived anti‐glycation approaches are overviewed. This work offers an understanding of AGEs to skin ageing and other chronic diseases and may provide perspectives for the development of anti‐glycation strategies.

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Section: Hazards Of Advanced Glycation End‐productsmentioning

confidence: 99%

“…51 In disease states associated with increased ROS production, there is a significant increase in skin AGE autofluorescence. 52…”

Section: Indicator Of Skin Advanced Glycation End Productsmentioning

confidence: 99%

The effects of advanced glycation end‐products on skin and potential anti‐glycation strategies

Wang,

Jiang,

Zhao

2024

Experimental Dermatology

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“…Skin's autofluorescence (AF) of advanced end products (AGEs) has shown promise for non-invasive diagnosis of diabetes and diabetes-associated diseases [15][16][17]. The major fluorophores in the normal skin include collagen, elastin, melanin, keratins, NADH and FAD [18,19].…”

Section: Introductionmentioning

confidence: 99%

UV-induced skin’s green autofluorescence is a biomarker for both non-invasive evaluations of the dosages of UV exposures of the skin and non-invasive prediction of UV-induced skin damage

Zhang

Ying

2022

Photochem Photobiol Sci

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It is crucial to discover biomarkers for non-invasive evaluations of the dosages of UV exposures to a person during post-UV exposure period, and for non-invasive prediction of UV-induced skin damage. Our current study has obtained findings: UVB exposures produced dose-dependent increases in skin's green autofluorescence (AF) intensity of mice, which were significantly associated with the UVB dosages. The UVC-induced green AF increases were dose dependent, which were highly associated with the UVC dosages. Moreover, both previous reports and our current study have collectively shown significant association between UVB/UVC dosages and UVB/UVC-induced skin damage. Collectively, our study has indicated that the UVB/UVC-induced skin's AF are first biomarkers for both non-invasive evaluations of the dosages of UV exposures to a person during post-UV exposure period and non-invasive and label-free prediction of UVB/UVC-induced skin damage.

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Challenges in Management of Diabetic Patient on Dialysis

Eldehni

Crowley

Selby

2022

Kidney and Dialysis

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Diabetes mellitus is the leading cause of end-stage kidney disease in many countries. The management of diabetic patients who receive dialysis can be challenging. Diabetic dialysis patients have higher rates of cardiovascular events and mortality due to metabolic factors and accelerated vascular calcification. Diabetic haemodialysis patients have high rates of haemodynamic instability which leads to organ ischaemia and end organ damage; autonomic dysfunction seems to play an important role in haemodynamic instability and abnormal organ perfusion during haemodialysis. Poor glycaemic control contributes to fluid overload and worse cardiovascular outcome. Xerostomia and thirst are the main drivers for fluid overload in haemodialysis patients and in peritoneal dialysis a chronic state of hyperhydration that is related to absorption of glucose from the PD fluids, protein loss and malnutrition contributes to fluid overload. Glycaemic control is of great importance and adjustments to diabetic agents are required. In haemodialysis, a reduction in insulin dose is recommended to avoid hypoglycaemia whereas in peritoneal dialysis an increase in insulin dose is often required. Foot ulcers and infection are more common in diabetic dialysis patients compared to non-diabetic dialysis patients or diabetic patients with normal renal function and regular surveillance for early identification is important. Ultimately, a multi-disciplinary approach which includes diabetologist, nephrologist, dietitians, microbiologist, vascular surgeon, interventional radiologist is required to address the complicated aspects of diabetic patient care on dialysis.

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Higher skin autofluorescence detection using AGE-Reader™ technology as a measure of increased tissue accumulation of advanced glycation end products in dialysis patients with diabetes: a meta-analysis

Cited by 3 publications

References 44 publications

The effects of advanced glycation end‐products on skin and potential anti‐glycation strategies

The effects of advanced glycation end‐products on skin and potential anti‐glycation strategies

UV-induced skin’s green autofluorescence is a biomarker for both non-invasive evaluations of the dosages of UV exposures of the skin and non-invasive prediction of UV-induced skin damage

Challenges in Management of Diabetic Patient on Dialysis

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