Higher Serum Dehydroepiandrosterone Sulfate Levels Are Protectively Associated with Depressive Symptoms in Men, But Not in Women: A Community-Based Cohort Study of Older Japanese

Michikawa, Takehiro; Nishiwaki, Yuji; Nakano, Makiko; Iwasawa, Satoko; Yamada, Masaya; Asakura, Keiko; Yoshioka, Noriyuki; Kuwahara, Erika; Takebayashi, Toru

doi:10.1016/j.jagp.2013.01.054

Cited by 18 publications

(32 citation statements)

References 48 publications

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“…Two studies, in fact, did not find any association between serum DHEAS levels and risk of depression, 5,30 whereas another two studies found an association only in men. 18,20 The differences between our study and others with negative findings may be explained by methodologic issues. First, we used the 30-item GDS for detection of depression, and the diagnosis was confirmed by geriatricians skilled in psychogeriatric medicine, whereas in other studies shorter forms of the GDS or other tools (like the Center for Epidemiologic Studies Depression Scale) were used alone.…”

Section: Discussioncontrasting

confidence: 74%

“…For continuous variables, normal distributions were tested using the Shapiro-Wilk test. Because previous research has shown that serum DHEAS levels significantly differ between genders and there is a significant sex by DHEAS level interaction for the onset of depression, 3,13,18,20 we tested if a similar interaction exists in our study using a Cox's regression analysis. Because this interaction was significant, all data analyses were made using gender-specific tertiles of baseline DHEAS.…”

Section: Discussionmentioning

confidence: 99%

“…Also, blood parameters that previous research has shown to be related to depression (fasting plasma glucose and cholesterol) were included in this work. 20 Fasting plasma glucose was measured with hexokinase glucose-6-phosphate dehydrogenase (Dimension Vista System; Siemens, Milan, Italy). Total cholesterol was calculated using the enzymatic method.…”

Section: Social and Medical Conditionsmentioning

confidence: 99%

See 2 more Smart Citations

Serum Dehydroepiandrosterone Sulfate and Incident Depression in the Elderly: The Pro.V.A. Study

Veronese

Rui

Bolzetta

et al. 2015

The American Journal of Geriatric Psychiatry

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Section: Discussioncontrasting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Social and Medical Conditionsmentioning

confidence: 99%

See 1 more Smart Citation

Serum Dehydroepiandrosterone Sulfate and Incident Depression in the Elderly: The Pro.V.A. Study

Veronese

Rui

Bolzetta

et al. 2015

The American Journal of Geriatric Psychiatry

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“…The Kurabuchi Study is a community‐based cohort study of aging that started in 2005 and involves functional assessment of an elderly population in Kurabuchi Town, Takasaki City, Gunma Prefecture, which is approximately 100 km north of Tokyo, Japan. In 2005 and 2006, we targeted all residents aged 65 and older who were not hospitalized or bedridden (n = 1,294) and administered a baseline survey to 834 of them (64.5%) at eight town community centers after obtaining written informed consent . There were no substantial demographic differences between the total eligible population and those who participated in the baseline health examinations; those aged 80 and older accounted for 28.2% of the total population and 26.4% of participants, and women accounted for 54.7% of the total population and 58.3% of participants .…”

Section: Methodsmentioning

confidence: 99%

“…In 2005 and 2006, we targeted all residents aged 65 and older who were not hospitalized or bedridden (n = 1,294) and administered a baseline survey to 834 of them (64.5%) at eight town community centers after obtaining written informed consent. [15][16][17] There were no substantial demographic differences between the total eligible population and those who participated in the baseline health examinations; those aged 80 and older accounted for 28.2% of the total population and 26.4% of participants, and women accounted for 54.7% of the total population and 58.3% of participants. 18 For the purposes of this study, we excluded residents who were already ADL dependent at baseline (7 residents with low Katz Index of Independence in ADL (Katz ADL) scores and 22 residents who were institutionalized) and those whose living circumstances or marital status were unknown (n = 36).…”

Section: Study Populationmentioning

confidence: 95%

Relationship Between Depressive Symptoms and Activity of Daily Living Dependence in Older Japanese: The Kurabuchi Study

Nakamura

Michikawa

Imamura

et al. 2017

J American Geriatrics Society

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Background/Objectives Few published studies have investigated the possibility of an association between depressive symptoms and dependence in activities of daily living (ADLs) in elderly adults. The objective of the study was to examine the association between depressive symptoms and future ADL dependence and to investigate how this association varies according to living circumstances and marital status. Design Community‐based prospective observational study. Setting Kurabuchi Town, Gunma Prefecture, Japan. Participants A total of 769 residents aged 65 and older were surveyed at baseline in 2005/06; they were followed up annually during the 7.5‐year study period (follow‐up rate, 99% (n = 763). Measurements Presence of depressive symptoms was defined as a score of 2 or greater on the five‐item Geriatric Depression Scale, and dependence in ADLs was defined as admission to a nursing home (institutionalization), eligibility for long‐term care (LTC), or need for help in any of the six basic ADL items in the Katz Index of Independence in ADLs. Results Depressive symptoms were observed in 232 of the 763 participants (30.4%). Those with depressive symptoms were more prone to future ADL dependence than those without (adjusted risk ratio = 1.29, 95% confidence interval = 1.04–1.61). There was no clear evidence of any effect modification according to living circumstances or marital status on this association, although living with other people or marriage was found to be associated with greater risk of institutionalization. Conclusion Our findings suggest that depressive symptoms are associated with future ADL dependence and that living circumstances (except for institutionalization) and marital status do not affect the association.

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Derivatization‐based quadruplex LC/ESI–MS/MS method for high throughput quantification of serum dehydroepiandrosterone sulfate

Aso

Ogawa

Nishimoto-Kusunose

et al. 2020

Biomedical Chromatography

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The quantification of the circulating dehydroepiandrosterone sulfate (DHEAS) might be of diagnostic help for several diseases. For the DHEAS quantification, LC/ESI–MS/MS has the advantage of a high specificity compared with immunoassay, whereas LC/ESI–MS/MS has room to improve the analysis throughput. One of the promising solutions to enhance the analysis throughput is sample‐multiplexing in the same injection, which can reduce the total LC/ESI–MS/MS run time. In this study, a quadruplex LC/ESI–MS/MS method was developed to quantify DHEAS in four different serum samples in a single run. After the four samples were separately deproteinized and derivatized with one of four Girard reagents (Girard reagent T, P and their isotopologs), the resulting samples were mixed, then injected into the LC/ESI–MS/MS. The applicability and advantage of the developed method were evaluated based on the analysis of nine batches of serum samples from healthy subjects (total 36 samples). The limit of quantitation was 0.050 μg/ml, which was sensitive enough for clinical laboratory use. The method was precise (intra‐ and inter‐assay RSDs ≤ 3.6%), accurate (94.4–108.1%) and robust for the matrix effects. The analysis time was also shortened by about 60% for 36 samples by the introduced method compared with the conventional method.

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Higher Serum Dehydroepiandrosterone Sulfate Levels Are Protectively Associated with Depressive Symptoms in Men, But Not in Women: A Community-Based Cohort Study of Older Japanese

Cited by 18 publications

References 48 publications

Serum Dehydroepiandrosterone Sulfate and Incident Depression in the Elderly: The Pro.V.A. Study

Serum Dehydroepiandrosterone Sulfate and Incident Depression in the Elderly: The Pro.V.A. Study

Relationship Between Depressive Symptoms and Activity of Daily Living Dependence in Older Japanese: The Kurabuchi Study

Derivatization‐based quadruplex LC/ESI–MS/MS method for high throughput quantification of serum dehydroepiandrosterone sulfate

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