Higher Serum Bisphenol A Levels in Diabetic Hemodialysis Patients

Turgut, Faruk; Sungur, Mustafa; Okur, Ramazan; Yaprak, Mustafa; Özsan, Müge; Üstün, İhsan; Gökçe, Cumali

doi:10.1159/000445203

Cited by 14 publications

(10 citation statements)

References 28 publications

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“…2018). Likewise, BPA concentrations were increased after a single hemodialysis session in patients with diabetes (Turgut et al. 2016) or uremia (Shintani 2001), and urinary BPA levels were significantly higher in patients using BPA-free dialyzers in comparison with BPA-containing dialyzers (Bosch-Panadero et al.…”

Section: Discussionmentioning

confidence: 99%

Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure

Iribarne-Durán

Artacho‐Cordón

Peña‐Caballero

et al. 2019

Environ Health Perspect

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Background:Newborns in neonatal intensive care units (NICUs) are in contact with a variety of medical products whose production might include synthetic chemicals with hormonal activity.Objectives:Our aim was to assess the content of bisphenol A (BPA) and parabens (PBs) and the hormone-like activities of a subset of medical products commonly used in NICUs in prolonged intimate contact with NICU newborns.Methods:Fifty-two NICU items were analyzed, determining the concentrations of BPA and PBs [methyl- (MeP), ethyl- (EtP), propyl- (PrP), and butylparaben (BuP)] and using the E-Screen and PALM-luciferase assays to measure the in vitro (anti-)estrogenic and (anti-)androgenic activity, respectively, of the extracts. Items found to have elevated BPA/PB content or hormone-like activities were further extracted using leaching methodologies.Results:BPA was found in three-fifths and PBs in four-fifths of tested NICU items, and ∼25% and ∼10% of extracts evidenced estrogenic and anti-androgenic activity, respectively. The highest BPA content was found in the three-way stopcock (>7.000 ng/g), followed by patterned transparent film dressing, gastro-duodenal feeding tubes, sterile gloves, single-lumen umbilical catheters, and intravenous (IV) infusion extension sets (concentrations ranged from 100 to 700 ng/g BPA). A total PB concentration (∑PBs) >100 ng/g was observed in several items, including light therapy protection glasses, patterned transparent film dressing, winged IV catheters, IV infusion extension sets, and textile tape. The highest estrogenic activity [>450 pM estradiol equivalent (normalE2eq)] was found in small dummy nipples, three-way stopcocks, and patterned transparent film dressing and the highest anti-androgenic activity [>5 mM procymidone equivalent units per gram (Proceq/g)] in small dummy nipples and three-way stopcocks.Discussion:According to these findings, neonates might be exposed to multiple sources of BPA and PBs in NICUs via inhalation, dermal, oral, and IV/parenteral routes. There is a need to address the future health implications for these extremely vulnerable patients and to adopt precautionary preventive measures as a matter of urgency. https://doi.org/10.1289/EHP5564

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Section: Discussionmentioning

confidence: 99%

Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure

Iribarne-Durán

Artacho‐Cordón

Peña‐Caballero

et al. 2019

Environ Health Perspect

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“…Therefore, in ESRD patients, decline in kidney function leads to the accumulation of BPA, yielding higher blood levels [28,30]. Moreover, during dialysis, the contact of blood with polymeric medical devices, such as dialyzers made of polycarbonate, polysulfone, or polyester, may expose ESRD patients to BPA [23,28,30,36]. In addition to dialyzers, BPA present in dialysate fluid is a source of exposure [23].…”

Section: Discussionmentioning

confidence: 99%

Overexposure to Bisphenol A and Its Chlorinated Derivatives of Patients with End-Stage Renal Disease during Online Hemodiafiltration

et al. 2019

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The health safety conditions governing the practice of online hemodiafiltration (OL-HDF) do not yet incorporate the risks related to the presence of endocrine disruptors such as bisphenol A (BPA). The aim of this study was to assess, for the first time, the exposure to BPA but also to its chlorinated derivatives (ClxBPA) (100 times more estrogenic than BPA) during OL-HDF. We demonstrated that BPA is transmitted by the different medical devices used in OL-HDF: ultrafilters, dialysis concentrate cartridges (and not only dialyzers, as previously described). Moreover, BPA has been found in dialysis water as well as in ultrapure dialysate and replacement fluid due to contamination of water coming from municipal network. Indeed, due to contaminations provided by both ultrafilters and water, high levels of BPA were determined in the infused replacement fluid (1033 ng.L−1) from the beginning of the session. Thus, our results demonstrate that dialysis water must be considered as an important exposure source to endocrine disruptors, especially since other micropollutants such as ClxBPA have also been detected in dialysis fluids. While assessment of the impact of this exposure remains to be done, these new findings should be taken into account to assess exposure risks in end-stage renal disease patients.

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“…In this regard, detectable amounts of BPA were reported to leach from hemodialyzers (Haishima et al 2001;Murakami et al 2007), and plasma BPA levels were lower in hemodialysis patients using polynephron (BPA-free) versus conventional polysulfone dialyzer membranes (Mas et al 2018). Likewise, BPA concentrations were increased after a single hemodialysis session in patients with diabetes (Turgut et al 2016) 2001), and urinary BPA levels were significantly higher in patients using BPA-free dialyzers in comparison with BPAcontaining dialyzers (Bosch-Panadero et al 2016). Similar studies have reported increased serum DEHP levels in hemodialysis patients (Wahl et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure

Iribarne-Durán

Artacho‐Cordón

Peña‐Caballero

et al. 2019

Environ Health Perspect

View full text Add to dashboard Cite

BACKGROUND: Newborns in neonatal intensive care units (NICUs) are in contact with a variety of medical products whose production might include synthetic chemicals with hormonal activity. OBJECTIVES: Our aim was to assess the content of bisphenol A (BPA) and parabens (PBs) and the hormone-like activities of a subset of medical products commonly used in NICUs in prolonged intimate contact with NICU newborns. METHODS: Fifty-two NICU items were analyzed, determining the concentrations of BPA and PBs [methyl-(MeP), ethyl-(EtP), propyl-(PrP), and butylparaben (BuP)] and using the E-Screen and PALM-luciferase assays to measure the in vitro (anti-)estrogenic and (anti-)androgenic activity, respectively, of the extracts. Items found to have elevated BPA/PB content or hormone-like activities were further extracted using leaching methodologies. RESULTS: BPA was found in three-fifths and PBs in four-fifths of tested NICU items, and ∼ 25% and ∼ 10% of extracts evidenced estrogenic and anti-androgenic activity, respectively. The highest BPA content was found in the three-way stopcock (>7:000 ng=g), followed by patterned transparent film dressing, gastro-duodenal feeding tubes, sterile gloves, single-lumen umbilical catheters, and intravenous (IV) infusion extension sets (concentrations ranged from 100 to 700 ng=g BPA). A total PB concentration (P PBs) >100 ng=g was observed in several items, including light therapy protection glasses, patterned transparent film dressing, winged IV catheters, IV infusion extension sets, and textile tape. The highest estrogenic activity [>450 pM estradiol equivalent (E 2 eq)] was found in small dummy nipples, three-way stopcocks, and patterned transparent film dressing and the highest anti-androgenic activity [>5 mM procymidone equivalent units per gram (Proceq=g)] in small dummy nipples and three-way stopcocks. DISCUSSION: According to these findings, neonates might be exposed to multiple sources of BPA and PBs in NICUs via inhalation, dermal, oral, and IV/parenteral routes. There is a need to address the future health implications for these extremely vulnerable patients and to adopt precautionary preventive measures as a matter of urgency.

show abstract

Higher Serum Bisphenol A Levels in Diabetic Hemodialysis Patients

Cited by 14 publications

References 28 publications

Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure

Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure

Overexposure to Bisphenol A and Its Chlorinated Derivatives of Patients with End-Stage Renal Disease during Online Hemodiafiltration

Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure

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