Higher serum 25(OH)D concentration is associated with lower risk of chronic otitis media with effusion: a case-control study

Walker, Rebecca E.; Bartley, Jim; Camargo, Carlos A.; Flint, David; Thompson, John M. D.; Mitchell, Edwin A.

doi:10.1111/apa.13908

Cited by 16 publications

(13 citation statements)

References 30 publications

(40 reference statements)

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“…Several clinical studies indicate that low vitamin D status is significantly associated with a high risk or severity of OM [ 12 13 14 15 ]. A recent case-control study by Cayir et al [ 12 ] showed that the mean serum 25(OH)D level was significantly lower in children with recurrent OM compared with controls (28.5 nmol/L vs. 72.9 nmol/L).…”

Section: Discussionmentioning

confidence: 99%

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Influence of Vitamin D Deficiency on Progression of Experimental Otitis Media in Rats

et al. 2018

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BackgroundVitamin D plays an important role in the immune response against infection. The purpose of the present study was to investigate the influence of vitamin D deficiency on the progression of otitis media (OM) using an experimental rat model.MethodsFour-week-old male Sprague-Dawley rats (n=72) were divided into two groups based on their diet: a control diet group (n=36) and a vitamin D-deficient diet group (n=36). After 8 weeks of diet, experimental OM was induced by inoculation of non-typeable Haemophilus influenzae in the middle ear cavity. The rats were evaluated with otomicroscopy to determine the inflammation in the middle ear mucosa on days 1, 2, 4, 7, and 14 post-inoculation. Bullae from sacrificed rats were collected and analyzed histologically.ResultsThe middle ear mucosa from rats with vitamin D deficiency showed a significantly higher thickness than that of controls during the course of OM. The maximum mucosal thickness was 56.0±9.1 µm in the vitamin D deficiency group, and 43.9±9.8 µm in the control group, although there was no significant difference in the tympanic membrane score between the two groups evaluated with otomicroscopy. An immunohistochemical study showed increased expression of interleukin 6 (IL-6) and tumor necrosis factor α in rats manifesting vitamin D deficiency and decreased expression of IL-10 compared with controls.ConclusionOur results showed that vitamin D deficiency may exacerbate the pathophysiological changes of OM via altered cytokine production. Therefore, maintaining vitamin D status in the optimal range may be beneficial for proper management of OM.

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Section: Discussionmentioning

confidence: 99%

“…Several clinical studies reported a significant association between vitamin D status and OM [ 12 13 14 15 ]. However, little is known about the role of vitamin D status in the pathophysiology of OM.…”

Section: Introductionmentioning

confidence: 99%

Influence of Vitamin D Deficiency on Progression of Experimental Otitis Media in Rats

et al. 2018

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“…Some stronger evidence comes from a case control study where the higher serum 25(OH)D concentrations, with or without supplementation, were associated with a lower risk of chronic otitis media with effusion (COME) in preschool children. They proposed that COME could be reduced by increasing serum 25(OH)D concentration through increased sun exposure, and higher dietary intake or vitamin D supplementation [52]. A more recent study strongly suggests that there is a significant association between vitamin D deficiency and follow-up outcomes of OME, as well as a strong effect of vitamin D on OME prognosis [53].…”

Section: Otitis Mediamentioning

confidence: 99%

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

2019

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Purpose Respiratory tract infections (RTIs) are a major cause of illness worldwide and the most common cause of hospitalization for pneumonia and bronchiolitis. These two diseases are the leading causes of morbidity and mortality among children under 5 years of age. Vitamin D is believed to have immunomodulatory effects on the innate and adaptive immune systems by modulating the expression of antimicrobial peptides, like cathelicidin, in response to both viral and bacterial stimuli. The aim of this review is to summarize the more recently published data with regard to potential associations of 25-hydroxyvitamin D [25(OH)D] with infectious respiratory tract diseases of childhood and the possible health benefits from vitamin D supplementation. Methods The literature search was conducted by using the PubMed, Scopus, and Google Scholar databases, with the following keywords: vitamin D, respiratory tract infection, tuberculosis, influenza, infancy, and childhood. Results Several studies have identified links between inadequate 25(OH)D concentrations and the development of upper or lower respiratory tract infections in infants and young children. Some of them also suggest that intervention with vitamin D supplements could decrease both child morbidity and mortality from such causes. Conclusions Most studies agree in that decreased vitamin D concentrations are prevalent among most infants and children with RTIs. Also, normal to high-serum 25(OH)D appears to have some beneficial influence on the incidence and severity of some, but not all, types of these infections. However, studies with vitamin D supplementation revealed conflicting results as to whether supplementation may be of benefit, and at what doses.

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“…Введение 1000 МЕ/сут витамина D восстанавливает значения D 25 (OH) в сыворотке крови до ≥30 нг/мл, и в большинстве случаев это приводило к значительному снижению риска возникновения ОСО [32]. По данным одного из последних клинических наблюдений выявлено, что низкий уровень 25-гидроксихолекальциферола предрасполагает к возникновению персистирующего течения экссудативного среднего отита, что является важнейшим предрасполагающим фактором к возникновению рецидивирующих острых средних отитов [33].…”

Section: бронхопульмонология и лорunclassified

Prospects for vitamin d in prevention of acute otitis media in children

Воробьёва¹,

Тулупов²,

Карпова³

et al. 2018

Med. sov.

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М.П. ВОРОБЬЁВА, Д.А. ТУЛУПОВ, к.м.н., Е.П. КАРПОВА, д.м.н., профессор, О.Г. НАУМОВ, к.м.н. ГБОУ ДПО «Российская медицинская академии непрерывного профессионального образования», Минздрава России, Москва О ПЕРСПЕКТИВАХ ПРИМЕНЕНИЯ ВИТАМИНА D В ПРОФИЛАКТИЧЕСКОМ ЛЕЧЕНИИ ОСТРЫХ СРЕДНИХ ОТИТОВ У ДЕТЕЙ В статье представлен обзор о роли витамина D в профилактическом лечении острых средних отитов у детей. Коротко дано патогенетическое обоснование действия витамина D на иммунную систему человека. Проанализированы причины актуальности применения препаратов витамина D в профилактике острых средних отитов у детей. Поставлены актуальные вопросы для дальнейшего изучения проблемы в педиатрической практике. Ключевые слова: витамин D, острый средний отит, дети. The article presents an overview of the role of vitamin D in prevention of acute otitis media in children. It provides brief pathogenetic justification of the action of vitamin D on the human immune system. The reasons for the urgency of the use of vitamin D supplements in prevention of acute otitis media in children are analysed. Topical issues to further study the problem in paediatric practice are presented.

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Higher serum 25(OH)D concentration is associated with lower risk of chronic otitis media with effusion: a case-control study

Abstract: This finding supports further investigation into whether the risk of COME could be reduced by increasing serum 25(OH)D concentration through increased sun exposure, higher dietary intake or vitamin D supplementation.

Cited by 16 publications

References 30 publications

Influence of Vitamin D Deficiency on Progression of Experimental Otitis Media in Rats

Influence of Vitamin D Deficiency on Progression of Experimental Otitis Media in Rats

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

Prospects for vitamin d in prevention of acute otitis media in children

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