Higher Seasonal Variation of Systemic Inflammation in Bipolar Disorder
Sara Dallaspezia,
Vincenzo Cardaci,
Mario Gennaro Mazza
et al.
Abstract:Seasonal rhythms affect the immune system. Evidence supports the involvement of immuno-inflammatory mechanisms in bipolar disorder (BD), with the neutrophil to lymphocyte ratio (NLR), and the systemic immune-inflammatory index (SII; platelets × neutrophils/lymphocytes) consistently reported to be higher in patients with BD than in HC, but seasonal rhythms of innate and adaptive immunity have never been studied. We retrospectively studied NLR and SII in 824 participants divided into three groups: 321 consecutiv… Show more
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