Higher risk of matrix metalloproteinase (<scp><i>MMP</i></scp>‐2, 7, 9) and tissue inhibitor of metalloproteinase (<scp><i>TIMP</i></scp>‐2) genetic variants to gallbladder cancer

Sharma, Kiran; Misra, Sanjeev; Kumar, Ashok; Mittal, Balraj

doi:10.1111/j.1478-3231.2012.02822.x

Cited by 57 publications

(33 citation statements)

References 54 publications

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“…Here, we investigated the relationship between MMP-12 rs652438 and CHD, although our results did not found find any association between this SNP and CHD. The MMP-2 rs2285053 CT and TT genotypes have been found to be significantly associated with increased risk of gallbladder cancer (Sharma et al, 2012), while the bile acid hyodeoxycholic acid has been shown to efficiently suppress atherosclerosis formation and plasma cholesterol levels in mice (Sehayek et al, 2001). Furthermore, the MMP-13 rs640198-T allele is associated with CHD severity, in terms of the number of stenoses and affected arteries (Vasku et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population

Cm¹,

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene polymorphisms were associated with CHD in Han Chinese. Our case-control study was involved with 1509 unrelated individuals, 12255Matrix metalloproteinases and coronary heart disease ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 12254-12261 (2015) including 777 CHD cases and 732 controls. We selected a total of five polymorphisms whose genotypes were determined using Sequenom iPLEX technology. Our results showed there were no significant associations between the five MMP gene polymorphisms and CHD risk at either genotype or allele levels (P > 0.05). Further subgroup analyses by sex were also unable to reveal any significant association (P > 0.05).In conclusion, no significant associations were found between the five MMP gene polymorphisms and the risk of CHD in Han Chinese.

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Section: Discussionmentioning

confidence: 99%

Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population

Cm¹,

et al. 2015

Genet. Mol. Res.

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“…Among these regulatory elements, the Sp1 binding site is particularly interesting. Among the well studied polymorphisms locate at promoter region of MMP-2, a C to T transition at -1306 and -735 disrupts a SP1 binding element results in decreased promoter activity and reduces the MMP-2 expression (Hajihoseini et al, 2011;Guo et al, 2012;Sharma et al, 2012). There is no data available to demonstrate the role of MMP-2 C-735T variants in susceptibility to breast cancer.…”

Section: Discussionmentioning

confidence: 99%

The MMP-2 -735 C Allele is a Risk Factor for Susceptibility to Breast Cancer

Yari¹,

Rahimi²,

Moradi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The expression of MMP genes has been demonstrated to be associated with tumor invasion, metastasis and survival rate for a variety of cancers. The functional promoter polymorphism MMP-2 C-735T is associated with decreased expression of the MMP-2 gene. The aim of present study was to detect any association between MMP-2 C-735T and susceptibility to breast cancer. Materials and Methods: The MMP-2 C-735T polymorphism was studied in 233 women (98 with breast cancer and 135 healthy controls). All studied women were from Kermanshah and Ilam provinces of Western Iran. The MMP-2 C-735T polymorphism was detected using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The frequencies of MMP-2 CC, CT and TT genotypes in healthy individuals were 59.3, 38.5 and 2.2%, respectively. However, in breast cancer patients, only CC (71.4%) and CT (28.6%) genotypes were observed (p=0.077). controls (78.5 %, p=0.048). The presence of C allele of MMP-2 increased the risk of breast cancer by 1.64-fold family history of cancer (67.3%, p=0.31). Conclusions: polymorphism is associated with increased risk of breast cancer. Also, the MMP-2 C allele might increase the risk of young onset breast cancer in our population.

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“…Genetic variants of MMP-2, MMP-7, and MMP-9 are associated with higher susceptibility of gallbladder cancer (Sharma et al 2012). Heparanase is a further enzyme playing a role in invasion and metastasis (Dutta and Poomachandra 2008;Wu et al 2008).…”

Section: Invasion and Spreadmentioning

confidence: 99%

Adenocarcinoma of the Gallbladder: Risk Factors and Pathogenic Pathways

Zimmermann

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Higher risk of matrix metalloproteinase (MMP‐2, 7, 9) and tissue inhibitor of metalloproteinase (TIMP‐2) genetic variants to gallbladder cancer

Abstract: This study suggests that genetic variants in MMP-2,7,9 and TIMP-2genes are associated with higher susceptibility of gallbladder cancer.

Cited by 57 publications

References 54 publications

Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population

Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population

The MMP-2 -735 C Allele is a Risk Factor for Susceptibility to Breast Cancer

Adenocarcinoma of the Gallbladder: Risk Factors and Pathogenic Pathways

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