Higher renal functional reserve in well-functioning renal grafts

Nakamura, Hiroshi; Daidoh, Yuichiro; Asano, Tomohiko; Mochizuki, Takashi

doi:10.1016/s0041-1345(96)00074-7

Cited by 4 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the small size of the study population renders statistical analysis not very reliable, but certain tendencies seem to appear: the basal GFR was higher in patients with very low RFR than those with significant RFR. This finding flies in the face of the well‐documented concept that the more the glomerular filtration is altered, the less it is able to respond to a protein load [19,20]. In constrast, our study showed that all the grafts had similar MFC, but that only some of them had the capacity to function ‘in slow motion’ under basal conditions.…”

Section: Discussionmentioning

confidence: 54%

Long‐term (≥20 yr) status of 14 cadaveric kidney‐transplant recipients

Delclaux

Morel

Fernandez

et al. 2001

Clinical Transplantation

View full text Add to dashboard Cite

The aim of this study was to analyze the status of patients with a successful long-term (> or =20 yr) kidney graft. Nineteen (8.1%) of the 234 recipients who received a cadaveric kidney transplant between 1968 and 1978 in our center are still alive 21.7+/-1.6 yr (mean+/-standard error of the mean) later with a functioning allograft. Function, including measurement of the renal functional reserve (RFR), histological status, and morbidity were evaluated. Fourteen patients agreed to participate in this study. Their current immunosuppressive regimens combined prednisone (P)+azathioprine (AZA) (n=9), P+AZA+cyclosporine (CsA) (n=3) or P+CsA (n=2). Although they described their quality of life as good, 10 patients had mild hypertension, 5 developed 10 malignancies (9 cutaneous), 5 had replicative hepatitis, 8 had osteopenia, and 6 had cataracts, but none had diabetes mellitus. Proteinuria was detected in 6 patients, but was always less than 1 g/d. Mean serum creatinine was 1.28+/-0.28 mg/dL and glomerular filtration rate was 54.5+/-5.3 mL/min/1.73 m2. RFR was present for 4 patients with a mean value of +14.8+/-1.9 mL/min. Their functional status was not correlated with the histological lesions observed in concomitant transplant biopsies. Kidney grafts are able to function well even more than 20 yr post-transplantation, with some having a RFR whose significance remains unknown. Morbidity is of minor clinical severity, but could be further reduced with optimized management. Moreover, transplantation is much less costly than hemodialysis.

show abstract

Section: Discussionmentioning

confidence: 54%