Higher regular coffee and tea consumption is associated with reduced endometrial cancer risk

Abstract

Several studies have investigated the associations between diet and endometrial cancer, but few have focused specifically on coffee and tea. In a hospital-based case-control study, we examined the associations between endometrial cancer risk and usual consumption of coffee, decaffeinated coffee, and black tea among 541 women with endometrial cancer and 541 women with an intact uterus but without a cancer diagnosis seen at Roswell Park Cancer Institute (Buffalo, New York) between 1982 and 1998. Daily frequency of consumption of coffee, decaffeinated coffee, and black tea in the few years prior to diagnosis in cases and questionnaire completion in controls was assessed with a self-administered epidemiologic questionnaire and categorized as none, 0.5 cups/d, 1-2 cups/d and >2 cups/d. Odds ratios (OR) and 95% confidence intervals (CI) for each category referent to nondrinkers were estimated with unconditional logistic regression adjusting for age, endometrial cancer risk factors and each beverage mutually adjusted for other beverages. Compared to nondrinkers, we observed a nonsignificant negative association with endometrial cancer risk among women who reported >2 cups/d regular coffee (OR 0.71, 95% CI 0.49-1.03), a significant inverse association with >2 cups/d black tea (OR 0.56, 95% CI 0.35-0.90) and a significant inverse association with >4 cups/d combined coffee and tea consumption (OR 0.47, 95% CI 0.28-0.80). These findings suggest coffee and tea may be important in reducing endometrial cancer risk.

A Prospective Cohort Study of Coffee Consumption and Risk of Endometrial Cancer over a 26-Year Follow-Up

“…A large Swedish cohort study found a RR of 0.75 for 4 or more cups of coffee per day vs. 1 cup or less per day, using baseline intake (16). Four case-control studies (18, 36–38) and two cohort studies in Norway (39) and Sweden (40) reported a non-significant inverse association, while two case-control studies in Europe (41, 42) reported a non-significant positive association.…”

“…Only two case-control studies assessed the relationship between decaffeinated coffee and risk of endometrial cancer, and found no association (18, 41). We found a non-significant inverse association with decaffeinated coffee intake of ≥ 2 cups/d.…”

Green and black tea in relation to gynecologic cancers

“…Tea intake and risk of endometrial cancer has been evaluated in several western populations including the US [26, 31, 32], Canada [33], and Europe [34, 35]. Although an inverse association was reported in one hospital-based case–control study [32], the remaining studies reported either positive or no associations. The combined OR for black tea and endometrial cancer was 1.20 (95% CI: 1.05, 1.38) (Table 4).…”

“… All studies Combined OR=1.20 (95% CI: 1.05, 1.38) c), d), e) Case-control studies Combined OR=1.25 (95% CI: 1.08, 1.44)c), f) a) ORs or RRs were adjusted for age [26, 31, 32, 34, 35], menstrual and/or reproductive factors [26, 31-33, 64], hormone use [26, 32, 33, 64], smoking [26, 31-33, 35], body size [26, 31-33, 64], and/or coffee intake [32, 35]. …”

Dietary and supplemental intake of one-carbon nutrients and the risk of type I and type II endometrial cancer: a prospective cohort study

“…However, currently known risk factors do not completely explain endometrial cancer risk. Recently, attention has focused on dietary intake in order to identify food and nutrients that might be associated with an increased or decreased risk of developing endometrial cancer [6][7][8][9][10][11].…”