Higher pulse pressure and risk for cardiovascular events in patients with essential hypertension: The Campania Salute Network

Mancusi, Costantino; Losi, Maria Angela; Izzo, Raffaele; Canciello, Grazia; Carlino, Maria Viviana; Albano, Giovanni; Luca, Nicola De; Trimarco, Bruno; Simone, Giovanni de

doi:10.1177/2047487317747498

Cited by 63 publications

(45 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, such studies should also take potential nonlinear relationships into account, as the effects of hypo-and hyperthyroidism on blood pressure come together within the normal range. This is important, as observational studies have shown that increased pulse pressure is an independent predictor of cardiovascular events in patients with hypertension (59,60), as well as a predictor for peripheral arterial disease (61).…”

Section: Discussionmentioning

confidence: 99%

Variation in Normal Range Thyroid Function Affects Serum Cholesterol Levels, Blood Pressure, and Type 2 Diabetes Risk: A Mendelian Randomization Study

Kuś

Marouli

et al. 2021

Thyroid

View full text Add to dashboard Cite

Background: Observational studies have demonstrated that variation in normal range thyroid function is associated with major cardiovascular risk factors, including dyslipidemia, hypertension, type 2 diabetes (T2D), and obesity. As observational studies are prone to residual confounding, reverse causality, and selection bias, we used a Mendelian randomization (MR) approach to investigate whether these associations are causal or not. Methods: Two-sample MR analysis using data from the largest available genome-wide association studies on normal range thyrotropin (TSH) and free thyroxine (fT4) levels, serum lipid levels, blood pressure measurements, T2D, and obesity traits (body mass index [BMI] and waist/hip ratio). Results: A one standard deviation (SD) increase in genetically predicted TSH levels was associated with a 0.037 SD increase in total cholesterol levels (p = 3.0 • 10-4). After excluding pleiotropic instruments, we also observed significant associations between TSH levels and low-density lipoprotein levels (b = 0.026 SD, p = 1.9 • 10-3), pulse pressure (b =-0.477 mmHg, p = 7.5 • 10-10), and T2D risk (odds ratio = 0.95, p = 2.5 • 10-3). While we found no evidence of causal associations between TSH or fT4 levels and obesity traits, we found that a one SD increase in genetically predicted BMI was associated with a 0.075 SD decrease in fT4 levels (p = 3.6 • 10-4). Conclusions: Variation in normal range thyroid function affects serum cholesterol levels, blood pressure, and T2D risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Variation in Normal Range Thyroid Function Affects Serum Cholesterol Levels, Blood Pressure, and Type 2 Diabetes Risk: A Mendelian Randomization Study

Kuś

Marouli

et al. 2021

Thyroid

View full text Add to dashboard Cite

show abstract

“…This largely agrees with our results regarding increased CV events (myocardial infarction, stroke, heart failure). Similar findings were reported by the previous investigation …”

Section: Discussionmentioning

confidence: 99%

The importance of pulse pressure on cardiovascular risk and total mortality in the general population: Is sex relevant?

Tadić

Quartı-Trevano

Bombelli

et al. 2018

J of Clinical Hypertension

View full text Add to dashboard Cite

The aim of the present study is to investigate the predictive value of pulse pressure (PP) on cardiovascular events in the general population and in both sexes, separately. The study involved 2045 participants from the PAMELA study who underwent 24-hour ambulatory blood pressure (BP) monitoring. The participants were followed from the initial medical visit for a time interval of 137 ± 23 months. It was found that office, home, and 24-hour blood pressures were significantly higher in the individuals who experienced cardiovascular (CV) events. Office, 24-hour, and daytime PP were independent predictors of CV events after adjustment for main demographic and clinical parameters in the whole study population. Nighttime PP was an additional independent predictor in men. In conclusion, PP represents an important predictor of cardiovascular events in the general population, particularly among men. Daytime and 24-hour PP have greater predictive importance than nighttime PP in the general population.

show abstract

“…Therefore, elevated PP can be used as a functional marker of target organ damage. 13 The study by Selvaraj et al 14 provided robust evidence on the role of PP in cardiovascular risk outcomes. However, when the predictive value of a 10-mmHg increase in PP was evaluated, a protective effect of elevated PP was found.…”

Section: Journal Of Transcatheter Interventionsmentioning

confidence: 99%

Pulse pressure as a risk factor for cardiovascular events: myth or reality?

Braite¹,

Santos²,

Neto³

et al. 2019

J Transcat Intervent

View full text Add to dashboard Cite

Background: Elevated systolic blood pressure and decreased diastolic blood pressure increase systolic load, with concurrent decrease in coronary perfusion pressure. Researches suggested a relation between elevated pulse pressure and morbidity and mortality due to cardiovascular events. This study set out to investigate whether pulse pressure is a predisposing risk factor for coronary heart disease or an aggravating risk factor in patients with coronary artery disease. Methods: A total of 5,027 pressure registers were evaluated. Pulse pressure was determined invasively in the ascending aorta. Coronary artery disease was diagnosed in the presence of obstructive lesion with luminal diameter reduction of 50% or more in at least one major epicardial vessel. Intergroup comparisons were performed using the unpaired Student's t test or Mann-Whitney test, as indicated. Categorical variables were compared using the Chi-squared test. Long-term survival was assessed using Kaplan-Meier curves. The p values ≤0.05 were considered significant. Results: Pulse pressure ranged from 20.0 to 160.0mmHg (mean ± standard deviation: 68.4±22.3; median: 66.0mmHg; 75th percentile: 82.0mmHg). Pulse pressure was associated with risk factors for coronary artery disease when patients with and without obstructive coronary artery disease were compared. However, pulse pressure was not an independent predictor of mortality. Conclusion: Pulse pressure is not an independent predictor of mortality in patients with coronary artery disease undergoing angiography.

show abstract

Higher pulse pressure and risk for cardiovascular events in patients with essential hypertension: The Campania Salute Network

Cited by 63 publications

References 43 publications

Variation in Normal Range Thyroid Function Affects Serum Cholesterol Levels, Blood Pressure, and Type 2 Diabetes Risk: A Mendelian Randomization Study

Variation in Normal Range Thyroid Function Affects Serum Cholesterol Levels, Blood Pressure, and Type 2 Diabetes Risk: A Mendelian Randomization Study

The importance of pulse pressure on cardiovascular risk and total mortality in the general population: Is sex relevant?

Pulse pressure as a risk factor for cardiovascular events: myth or reality?

Contact Info

Product

Resources

About