Higher Prevalence of Vitamin D Deficiency in Mothers of Rachitic Than Nonrachitic Children

Dawodu, Adekunle; Agarwal, Mukesh; Sankaran-Kutty, M.; Hardy, Denis; Kochiyil, Jose; Badrinath, Padmanabhan

doi:10.1016/j.jpeds.2005.03.001

Cited by 86 publications

(79 citation statements)

References 10 publications

(12 reference statements)

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“…The strong correlation between 25(OH)D concentrations in newborns and their mothers in both groups indicates that adequate vitamin D intake for mothers should be emphasized during pregnancy and lactation (Hollis and Wagner, 2004;Specker, 2004;Dawodu et al, 2005;Hollis and Wagner, 2006;Javaid et al, 2006). The last finding of the study, which shows that 25(OH)D concentrations were deficient in mothers of both groups (study and control group), has important public health implications in our country (Hatun et al, 2005).…”

Section: Discussionmentioning

confidence: 78%

Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers

et al. 2007

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Background/Objectives: There are other benefits of vitamin D than those for bone health. To determine the association of serum 25-hydroxy vitamin D (25(OH)D) concentrations in newborns with acute lower respiratory infection (ALRI) and without clinical signs of rickets, and their mothers. The design comprises a hospital-based case-control study. Subjects/Methods: The study group consisted of 25 newborns with ALRI who were admitted to neonatal intensive care unit and their mothers. Controls were 15 healthy newborns of the same age as the study group and their mothers. A commercial radioimmunoassay was used to measure 25(OH)D concentrations in serum for assessing vitamin D status. Results: The two groups were similar in gestational week, birth weight, birth height, head circumference, age and gender. The mean serum 25(OH)D concentrations in the study group newborns were lower than those of the control group (9.12±8.88 ng/ml and 16.33 ± 13.42 ng/ml, respectively) (P ¼ 0.011). Also, mean serum 25(OH)D concentrations in the mothers of the study group were lower than those in the mothers of the control group (13.38±16.81 ng/ml and 22.79±16.93 ng/ml respectively) (P ¼ 0.012). In 87.5% of all newborns and 67.5% of all mothers, serum 25(OH)D concentrations were lower than 20 ng/ml. The 25(OH)D concentrations of newborns were highly correlated with mothers' serum 25(OH)D concentrations. Conclusions: Our findings suggest that newborns with subclinical vitamin D deficiency may have an increased risk of suffering from ALRI. The strong positive correlation between newborns' and mothers' 25(OH)D concentrations shows that adequate vitamin D supplementation of mothers should be emphasized during pregnancy especially in winter months.

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Section: Discussionmentioning

confidence: 78%

Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers

et al. 2007

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“…Because the sources of calcium will vary by country and region, we recommend that clinicians develop a dietary calcium intake questionnaire specific to their country/region. the prevention of NR is based on strong evidence [1,2,[24][25][26][27] supported by the increased incidence of NR with 25OHD concentrations <30 nmol/l (1 ng/ml = 2.5 nmol/l). Our definition is consistent with that of the Institute of Medicine (IOM) [28] .…”

Section: Global Rickets Consensusmentioning

confidence: 99%

“…Hypocalcemia (see section 4.1.2) or other early biochemical signs of rickets (such as elevated ALP and PTH) are present before radiographic signs of NR occur in unsupplemented neonates and infants [82,83] . A high percentage of mothers of infants with symptomatic vitamin D deficiency are from highrisk groups who are vitamin D deficient and exclusively breast-feeding [11,24,[83][84][85] .…”

Section: Evidencementioning

confidence: 99%

Global Consensus Recommendations on Prevention and Management of Nutritional Rickets

Munns¹,

Shaw²,

Kiely³

et al. 2016

Horm Res Paediatr

353

477

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Background: Vitamin D and calcium deficiencies are common worldwide, causing nutritional rickets and osteomalacia, which have a major impact on health, growth, and development of infants, children, and adolescents; the consequences can be lethal or can last into adulthood. The goals of this evidence-based consensus document are to provide health care professionals with guidance for prevention, diagnosis, and management of nutritional rickets and to provide policy makers with a framework to work toward its eradication. Evidence: A systematic literature search examining the definition, diagnosis, treatment, and prevention of nutritional rickets in children was conducted. Evidence-based recommendations were developed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system that describes the strength of the recommendation and the quality of supporting evidence. Process: Thirty-three nominated experts in pediatric endocrinology, pediatrics, nutrition, epidemiology, public health, and health economics evaluated the evidence on specific questions within five working groups. The consensus group, representing 11 international scientific organizations, participated in a multiday conference in May 2014 to reach a global evidence-based consensus. Results: This consensus document defines nutritional rickets and its diagnostic criteria and describes the clinical management of rickets and osteomalacia. Risk factors, particularly in mothers and infants, are ranked, and specific prevention recommendations including food fortification and supplementation are offered for both the clinical and public health contexts. Conclusion: Rickets, osteomalacia, and vitamin D and calcium deficiencies are preventable global public health problems in infants, children, and adolescents. Implementation of international rickets prevention programs, including supplementation and food fortification, is urgently required. nology, pediatrics, nutrition, epidemiology, public health, and health economics evaluated the evidence on specific questions within five working groups. The consensus group, representing 11 international scientific organizations, participated in a multiday conference in May 2014 to reach a global evidence-based consensus. Results: This consensus document defines nutritional rickets and its diagnostic criteria and describes the clinical management of rickets and osteomalacia. Risk factors, particularly in mothers and infants, are ranked, and specific prevention recommendations including food fortification and supplementation are offered for both the clinical and public health contexts. Conclusion: Rickets, osteomalacia, and vitamin D and calcium deficiencies are preventable global public health problems in infants, children, and adolescents. Implementation of international rickets prevention programs, including supplementation and food fortification, is urgently required. Key WordsRickets · Nutrition · Vitamin D · Calcium · Consensus recommendations Abstract Background: Vitamin D and ca...

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“…Prevalence rates in Delhi are 4-27%, 20% in central India, and 3.3% among preschool children in Calcutta. [2][3][4][5] Incidence of rickets is considered to increase with latitude and malnutrition, which also applies to tea garden community of Assam. Singleton R in his article on rickets and vitamin D deficiency in Alaska native children concluded that rickets incidence increased with latitude and rickets/vitamin D deficiency cases are more likely to have malnutrition (OR 38.1; 95% CI 4.9-294).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of skeletal deformity due to nutritional rickets in children between 1 and 18 years in tea garden community

Chabra

Tahbildar

Sharma

et al. 2016

Journal of Clinical Orthopaedics and Trauma

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Higher Prevalence of Vitamin D Deficiency in Mothers of Rachitic Than Nonrachitic Children

Cited by 86 publications

References 10 publications

Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers

Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers

Global Consensus Recommendations on Prevention and Management of Nutritional Rickets

Prevalence of skeletal deformity due to nutritional rickets in children between 1 and 18 years in tea garden community

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