Higher prevalence of chronic kidney disease and shorter renal survival in patients with chronic hepatitis C virus infection

Satapathy, Sanjaya K.; Lingisetty, Chandra Sekhar; Williams, Susan E.

doi:10.1007/s12072-011-9284-9

Cited by 67 publications

(82 citation statements)

References 24 publications

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“…The results of this meta-analysis suggest that positive serologic status for anti-HCV antibody is associated with an increased risk of proteinuria but not with reduced GFR compared with anti-HCV-negative patients. The relationship between HCV and proteinuria (adjusted RR, 1.47; 95% CI, 1.12, 1.94; P=0.006) is based only on four surveys but is in keeping with results from other sources (18,33). It has been repeatedly shown that proteinuria predicts the progression of renal disease as well as cardiovascular morbidity and mortality in patients with diabetes as well as the general population (34,35).…”

Section: Discussionsupporting

confidence: 62%

“…Thirty-eight observational studies were considered eligible but were excluded because outcomes from HCV-HIV co-infected participants (n=32) (15), patients with diabetes (n=2) (16,17), HCV-infected patients (n=1) (18), and chronic GN patients only (n=1) (19) were reported. Two studies did not account for important potential confounders in their analyses (20,21).…”

Section: Literature Reviewmentioning

confidence: 99%

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Hepatitis C Virus Infection and Kidney Disease

Fabrizi

Martin

Dixit

et al. 2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Hepatitis C virus (HCV) infection and kidney disease are both highly prevalent diseases. The association between HCV and GN has been supported by previous research but little is known about the relationship between HCV and kidney disease.Design, setting, participants, & measurements A systematic review of the published medical literature was conducted to determine if HCV is associated with increased likelihood of kidney disease in the general population. A random-effects model was used to generate a summary estimate of the relative risk for kidney disease, defined as an estimated GFR ,60 ml/min per 1.73 m 2 or proteinuria, with HCV across the published studies.Results Nine clinical studies (817,917 unique individuals) were identified. Pooling of study results demonstrated the absence of a relationship between HCV seropositive status and reduced estimated GFR (adjusted relative risk, 1.12; 95% confidence interval, 0.91, 1.38; P=0.28) according to the random-effects model. HCV seropositive serology was an independent and significant risk factor for proteinuria (defined by urine dipstick test or spot urine albumin/creatinine ratio) in the general population, with a summary estimate for adjusted relative risk of 1.47 (95% confidence interval, 1.12, 1.94; P=0.006). Significant heterogeneity was observed between studies (Ri=0.82; P value by Q test, ,0.001).Conclusions This meta-analysis shows that HCV is independently associated with proteinuria but not with reduced GFR in the general population. Substantial heterogeneity occurred.

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Section: Discussionsupporting

confidence: 62%

Section: Literature Reviewmentioning

confidence: 99%

Hepatitis C Virus Infection and Kidney Disease

Fabrizi

Martin

Dixit

et al. 2012

Clinical Journal of the American Society of Nephrology

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“…Data from the DOPPS study show that prevalence rates vary widely worldwide, reaching 12.9% in Spain [4]; however, this prevalence is now considerably decreasing when compared to the findings of previous analyses [5]. In addition, survival period is shorter in infected patients than that in noninfected patients [6,7,8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

Universal Sustained Viral Response to the Combination of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with/without Ribavirin in Patients on Hemodialysis Infected with Hepatitis C Virus Genotypes 1 and 4

Abad¹,

Vega²,

Hernández³

et al. 2017

Am J Nephrol

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Background: Hepatitis C virus (HCV) infection is highly prevalent among patients on hemodialysis (HD) and is associated with poor prognosis. Treatment with interferon and ribavirin is poorly tolerated, and few data are available on the impact of new direct-acting antivirals (DAAs). This study was intended to analyze the efficacy and safety of treatment with a combination of ombitasvir/paritaprevir/ritonavir and dasabuvir with/without ribavirin in HCV-infected patients on HD from 3 hospitals. Methods: This is a multicentric study. We analyze the clinical course of all patients on HD with HCV infection who had been treated with the combination of ombitasvir/paritaprevir/ritonavir and dasabuvir in 3 hospitals in Madrid, Spain. All patients under treatment had undergone Transient elastography (FibroScan®) and HCV RNA (PCR) and HCV genotype were determined simultaneously. Results: Thirty-five patients aged 53.3 ± 8.9 years (68.6% males) and with genotypes 1 and 4 were treated with the DAA regimen, and 17 were also given ribavirin. The most common etiology was glomerular disease. Sustained viral response was achieved in 100% of patients. Adverse effects were negligible, and no patient had to discontinue treatment. The most significant side effect was anemia, which led to a significant increase in the dose of erythropoiesis-stimulating agents. Anemia was more marked in patients receiving ribavirin. No patients required transfusions. Conclusion: A combination of ombitasvir/paritaprevir/ritonavir and dasabuvir with/without ribavirin for the treatment of HCV in patients on HD is highly effective and causes minimal side effects. This regimen represents a major advance in disease management. A considerable improvement in prognosis seems likely.

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“…Satapathy et al 9 llevan a cabo un estudio retrospectivo para determinar la presencia de insuficiencia renal crónica mediante el filtrado glomerular estimado y la proteinuria a través de tira reactiva en 552 VHC-positivos y 313 controles y se halla una mayor prevalencia de insuficiencia renal y su asociación independiente del VHC.…”

Section: Discussionunclassified

Microalbuminuria e insuficiencia renal en la infección crónica por el virus de la hepatitis C

Rabih¹,

García-Agudo²,

Burillo³

et al. 2012

Gastroenterología y Hepatología

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Higher prevalence of chronic kidney disease and shorter renal survival in patients with chronic hepatitis C virus infection

Abstract: Chronic HCV infection was associated with a significantly higher prevalence of CKD compared with controls, as well as significantly shorter renal survival. A higher baseline viral load is an independent predictor of CKD.

Cited by 67 publications

References 24 publications

Hepatitis C Virus Infection and Kidney Disease

Hepatitis C Virus Infection and Kidney Disease

Universal Sustained Viral Response to the Combination of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with/without Ribavirin in Patients on Hemodialysis Infected with Hepatitis C Virus Genotypes 1 and 4

Microalbuminuria e insuficiencia renal en la infección crónica por el virus de la hepatitis C

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