Higher platelet counts are associated with metabolic syndrome independent of fatty liver diagnosis

Fang, Kuan Chieh; Cheng, Yuan-Lung; Su, Chien–Wei; Wang, Yuan Jen; Lan, Keng‐Li; Huo, Teh Ia; Huang, Yi Hsiang; Chu, Chi‐Jen; Lin, Chih-Chieh; Hou, Ming; Lin, Han Chieh; Lee, Fa Yauh; Wu, Jaw Ching; Lee, Shou Dong

doi:10.1016/j.jcma.2016.07.003

Cited by 26 publications

(13 citation statements)

References 40 publications

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“…In our study, the platelet count and COL4‐7S were only a little affected by aging in practice. However, there are normally no changes in the platelet count or COL4‐7S with older age in healthy people, ( 44,45 ) The reason why COL4‐7S was affected by age, although a little, was that subjects in this study were patients with NAFLD and liver fibrosis, and these parameters were affected by progression of liver fibrosis with aging. The present NITs are diagnostic methods for advanced fibrosis ≥ stage 3, but they may be necessary to identify it and screen from stage F2 for intervention and a cure.…”

Section: Discussionmentioning

confidence: 93%

Type IV Collagen 7S Is the Most Accurate Test For Identifying Advanced Fibrosis in NAFLD With Type 2 Diabetes

Ishiba¹,

Sumida

Seko³

et al. 2020

Hepatol Commun

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This study aimed to examine whether the diagnostic accuracy of four noninvasive tests (NITs) for detecting advanced fibrosis in nonalcoholic fatty liver disease (NAFLD) is maintained or is inferior to with or without the presence of type 2 diabetes. Overall, 874 patients with biopsy‐proven NAFLD were enrolled. After propensity‐score matching by age, sex, and the prevalence of dyslipidemia, 311 patients were enrolled in each group of with or without diabetes. To evaluate the effect of diabetes, we compared the diagnostic accuracy of the fibrosis‐4 (FIB‐4) index, the NAFLD fibrosis score (NFS), the aspartate aminotransferase to platelet ratio index (APRI), and type IV collagen 7S (COL4‐7S) in patients with NAFLD with and without diabetes. The areas under the receiver operating characteristic curve (AUROC) for identifying advanced fibrosis in patients without diabetes were 0.879 for the FIB‐4 index, 0.851 for the NFS, 0.862 for the APRI, and 0.883 for COL4‐7S. The AUROCs in patients with diabetes were 0.790 for the FIB‐4 index, 0.784 for the NFS, 0.771 for the APRI, and 0.872 for COL4‐7S. The AUROC of COL4‐7S was significantly larger than that of the other NITs in patients with NAFLD with diabetes than in those without diabetes. The optimal high and low cutoff points of COL4‐7S were 5.9 ng/mL and 4.8 ng/mL, respectively. At the low cutoff point, the accuracy of COL4‐7S was better than that of the other NITs, especially in patients with diabetes. Conclusion: COL4‐7S measurement might be the best NIT for identifying advanced fibrosis in NAFLD, especially in NAFLD with diabetes.

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Section: Discussionmentioning

confidence: 93%

Type IV Collagen 7S Is the Most Accurate Test For Identifying Advanced Fibrosis in NAFLD With Type 2 Diabetes

Ishiba¹,

Sumida

Seko³

et al. 2020

Hepatol Commun

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“…Platelet to lymphocyte ratio (PLR) has been reported to be associated with the prognosis of CRC 16–18. Previous studies indicated that increased platelet counts were associated with MetS in adults 19,20. Akboga et al reported that increased PLR was significantly associated with MetS in a Turkish population 21.…”

Section: Introductionmentioning

confidence: 99%

Impact of platelet to lymphocyte ratio and metabolic syndrome on the prognosis of colorectal cancer patients

You¹,

Zhang²,

Shen³

et al. 2017

OTT

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ObjectiveThe aim of this study was to evaluate the prognostic value of both platelet to lymphocyte ratio (PLR) and metabolic syndrome (MetS) in colorectal cancer (CRC) patients.Patients and methodsWe retrospectively enrolled 1,163 CRC patients. Preoperative values of PLR were stratified into three groups according to cut-off values of 120 and 220. The Kaplan–Meier analysis was used to calculate cumulative survival rate related to PLR and MetS. Cox proportional hazard regression models were used to analyze potential risk factors and the prognosis associated with PLR and MetS in CRC patients.ResultsPLR was significantly higher in the MetS(+) group as compared to MetS(−) group (P=0.039). An elevated PLR was significantly associated with mortality (P=0.014), but not the existence of MetS (P=0.235). In multivariate regression analysis, PLR was an independent risk factor for overall survival (OS) (P=0.046). For the subgroup with a PLR >220, MetS was an independent predictor for both OS and disease-free survival (P=0.039 and P=0.047, respectively) by multivariate analysis adjusting for confounding covariates. In addition, the presence of MetS was associated with a 2-fold increased risk of mortality and tumor recurrences (hazard ratio [HR] =2.0 and HR =1.9, P<0.05, respectively).ConclusionPreoperative PLR was associated with MetS in CRC patients. Testing for the combined presence of PLR and MetS could potentially improve the predictive accuracy of CRC prognosis.

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“…Furthermore, the literature suggests that estrogen causes less severity of fibrosis,[ 27 ] whereas in our study majority patients were females in fertile age, however, no difference in the severity of liver fibrosis was observed among genders. One interesting finding of this study was a raised ALT and platelets observed in females compared to males; it is hypothesized to be that could be due to insulin resistance and hepatosteatosis, which is evident in previous literature,[ 28 29 ] however, this is one limitation of the study as testing for metabolic syndrome (fasting lipid profile, FBS, etc.) was not incorporated, Further studies are recommended to get a clear association with this aspect.…”

Section: Discussionmentioning

confidence: 63%

Relationship of FIB-4 index with transient elastography in chronic hepatitis C patients having APRI ≥ 0.5 - ≤2 in a resource-limited setting in Pakistan

Ishtiaq

Shah

Iftikhar

et al. 2020

J Family Med Prim Care

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Objective: We aimed to study the extent of liver fibrosis in chronic hepatitis C patients with indeterminate APRI score of ≥ 0.5 - ≤2 (between higher and lower cut off value) and correlate it to transient elastography (TE) and FIB 4 index. Method: A cross-sectional study, 80 patients with CHC mono infection, APRI score ≥ 0.5 - ≤2 were interviewed from the cohort visiting the CHC program clinic at a tertiary care hospital in Karachi, Pakistan. Data were analyzed using STATA 14.0 and R 3.5.2 and SPSS 24.0 software according to their capabilities. Result: Of 80 patients, 50 (62.5%) were females and 30 (37.5%) were males with mean (±SD) ages of 41.73 (±11.5) years and 41.16 (±9.24) years respectively. The FIB 4 value among indeterminate APRI was reported as 1.47 (IQR 1.05-2.43). TE categories was reported: F0-F1 ( n = 29; 36%), F1-F2 ( n = 10; 12.5%), F2 ( n = 9; 11.2%) F3 ( n = 13; 16.2%), F3-F4 ( n = 1; 1.2%) F4 ( n = 18; 22.5%). FIB4 had a moderate positive correlation with TE while a weak positive correlation was found between APRI and TE (0.488, P < 0.0001 and 0.289, P < 0.001, respectively). TE was taken as a gold standard and compared with FIB4. The model constructed reported FIB4 as a good prediction for liver fibrosis with diagnostic accuracy 72%. Conclusion: The combination of two serum markers proves to be a low-cost noninvasive testing strategy for CHC patients having an indeterminate APRI score. By being readily accessible both biochemical scores can simplify liver assessment in lower middle-income countries (LMIC) and help family physicians to take appropriate decisions about treatment initiation with minimum delays.

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Higher platelet counts are associated with metabolic syndrome independent of fatty liver diagnosis

Abstract: There is a significant correlation between PC and MS, and the correlation exists independent of gender, age, and fatty liver. PC may act as a surrogate marker for MS, and physicians should be concerned with the presence of MS among patients with high PC.

Cited by 26 publications

References 40 publications

Type IV Collagen 7S Is the Most Accurate Test For Identifying Advanced Fibrosis in NAFLD With Type 2 Diabetes

Type IV Collagen 7S Is the Most Accurate Test For Identifying Advanced Fibrosis in NAFLD With Type 2 Diabetes

Impact of platelet to lymphocyte ratio and metabolic syndrome on the prognosis of colorectal cancer patients

Relationship of FIB-4 index with transient elastography in chronic hepatitis C patients having APRI ≥ 0.5 - ≤2 in a resource-limited setting in Pakistan

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