ABSTRACT. This paper resolves affirmatively Koplienko's conjecture of 1984 on existence of higher order spectral shift measures. Moreover, the paper establishes absolute continuity of these measures and, thus, existence of the higher order spectral shift functions. A spectral shift function of order n ∈ N is the func-for every sufficiently smooth function f , where H is a self-adjoint operator defined in a separable Hilbert space H and V is a self-adjoint operator in the n-th Schatten-von Neumann ideal S n . Existence and summability of η 1 and η 2 were established by Krein in 1953 and Koplienko in 1984, respectively, whereas for n > 2 the problem was unresolved. We show that η n,H,V exists, integrable, andfor some constant c n depending only on n ∈ N. Our results for η n rely on estimates for multiple operator integrals obtained in this paper. Our method also applies to the general semi-finite von Neumann algebra setting of the perturbation theory.