Floquet higher-order topological insulators and superconductors (HOTI/SCs) with an order-two space-time symmetry or antisymmetry are classified. This is achieved by considering unitary loops, whose nontrivial topology leads to the anomalous Floquet topological phases, subject to a spacetime symmetry/antisymmetry. By mapping these unitary loops to static Hamiltonians with an order-two crystalline symmetry/antisymmetry, one is able to obtain the K groups for the unitary loops and thus complete the classification of Floquet HOTI/SCs. Interestingly, we found that for every order-two nontrivial space-time symmetry/antisymmetry involving a half-period time translation, there exists a unique order-two static crystalline symmetry/antisymmetry, such that the two symmetries/antisymmetries give rise to the same topological classification. Moreover, by exploiting the frequency-domain formulation of the Floquet problem, a general recipe that constructs model Hamiltonians for Floquet HOTI/SCs is provided, which can be used to understand the classification of Floquet HOTI/SCs from an intuitive and complimentary perspective. CONTENTS 32 A. Equivalent classification with symmetrized evolution operators 32 B. Decomposition of time evolution operators 32 C. Order of HOTI/SCs and symmetry-breaking mass terms 32 References 33