Higher mortality of severe influenza patients with probable aspergillosis than those with and without other coinfections

Ku, Yee Huang; Chan, Khee Siang; Yang, Chengxu; Tan, Che-Kim; Chuang, Yin Ching; Yu, Wen Liang

doi:10.1016/j.jfma.2017.06.002

Cited by 78 publications

(85 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were four larger case series which included immunocompetent patients with Influenza and IPA; however, these were not listed above as granular data were not available for individual patients (Ku et al, 2017; Martín-Loeches et al, 2011; van de Veerdonk et al, 2017; Wauters et al, 2012). …”

Section: Figmentioning

confidence: 99%

Invasive pulmonary aspergillosis and influenza co-infection in immunocompetent hosts: case reports and review of the literature

Shah

Hsiao

Kirsch

et al. 2018

Diagnostic Microbiology and Infectious Disease

View full text Add to dashboard Cite

Invasive pulmonary aspergillosis (IPA) is classically considered an illness of severely immunocompromised patients with limited host defenses. However, IPA has been reported in immunocompetent but critically ill patients. This report describes two fatal cases of pathologically confirmed IPA in patients with Influenza in the intensive care unit. One patient had Influenza B infection, whereas the other had Influenza A H1N1. Both patients died despite broad-spectrum antimicrobials, mechanical ventilation, and vasopressor support. Microscopic and histologic postmortem examination confirmed IPA. Review of the English language and foreign literature indicates that galactomannan antigen testing and classic radiologic findings for IPA may not be reliable in immunocompetent patients. Respiratory cultures which grow Aspergillus species in critically ill patients, particularly those with underlying Influenza infection, should not necessarily be disregarded as contaminants or colonizers. Further research is needed to better understand the immunological relationship between Influenza and IPA for improved prevention and treatment of Influenza and Aspergillus co-infections.

show abstract

Section: Figmentioning

confidence: 99%

Invasive pulmonary aspergillosis and influenza co-infection in immunocompetent hosts: case reports and review of the literature

Shah

Hsiao

Kirsch

et al. 2018

Diagnostic Microbiology and Infectious Disease

View full text Add to dashboard Cite

show abstract

“…9 The Taiwanese study did not reveal any high-risk patients. 10 The proportion of patients receiving antifungal therapy was significantly lower in the Taiwanese cohort (67% vs 91% and 92%, P = 0.007). The median time to initiation of antifungal therapy from the day of influenza diagnosis was shorter in survivors than in non-survivors (2 days vs 9 days, P = 0.06) in the Dutch cohort, but was similar in the Taiwanese (9 days vs 8 days) and Belgium (4 days vs 5 days) cohorts.…”

Section: Dear Editormentioning

confidence: 84%

“…In Taiwan, a retrospective study enrolled adult patients with severe influenza in a tertiary center over a 15-month period. 10 IAA was identified in 21 (17%) of 124 influenza cases with a similar mortality of 67% (14/21). In this letter, we compare the clinical aspects and risk factors for mortality of the three cohorts with IAA.…”

Section: Dear Editormentioning

confidence: 91%

“…8 These results were similar to those in the Taiwanese cohort for ICU mortality (67% vs 15%, P < 0.001) and the use of mechanical ventilation (100% vs 69%, P = 0.002). 10 Both showed substantial impact of IAA on severe influenza patients.…”

Section: Dear Editormentioning

confidence: 97%

“…In this letter, we compare the clinical aspects and risk factors for mortality of the three cohorts with IAA. [8][9][10] The results of comparing the three studies are shown in Table 1. Categorical variables were compared using the chisquare test or Fisher exact test and P < 0.05 was considered statistically significant.…”

Section: Dear Editormentioning

confidence: 99%

See 2 more Smart Citations

Aspergillosis related to severe influenza: A worldwide phenomenon?

Liu

Chan

et al. 2019

Clinical Respiratory J

View full text Add to dashboard Cite

Analysis of risk factors of fungal superinfections in viral pneumonia patients: A systematic review and meta‐analysis

Lin

Zhong

et al. 2022

Immunity Inflam & Disease

View full text Add to dashboard Cite

Background Infections with fungi, such as Aspergillus species, have been found as common complications of viral pneumonia. This study aims to determine the risk factors of fungal superinfections in viral pneumonia patients using meta‐analysis. Objective This study aims to determine the risk factors of fungal infection s in viral pneumonia patients using meta‐analysis. Methods We reviewed primary literature about fungal infection in viral pneumonia patients published between January 1, 2010 and September 30, 2020, in the Chinese Biomedical Literature, Chinese National Knowledge Infrastructure, Wanfang (China), Cochrane Central Library, Embase, PubMed, and Web of Science databases. These studies were subjected to an array of statistical analyses, including risk of bias and sensitivity analyses. Results In this study, we found a statistically significant difference in the incidence of fungal infections in viral pneumonia patients that received corticosteroid treatment as compared to those without corticosteroid treatment ( p < .00001). Additionally, regarding the severity of fungal infections, we observed significant higher incidence of invasive pulmonary aspergillosis (IPA) in patients with high Acute Physiology and Chronic Health Evaluation (APACHE) II scores ( p < .001), tumors ( p = .005), or immunocompromised patients ( p < .0001). Conclusions Our research shows that corticosteroid treatment was an important risk factor for the development of fungal infection in patients with viral pneumonia. High APACHE II scores, tumors, and immunocompromised condition are also important risk factors of developing IPA. The diagnosis of fungal infection in viral pneumonia patients can be facilitated by early serum galactomannan (GM) testing, bronchoalveolar lavage fluid Aspergillus antigen testing, culture, and biopsy.

show abstract

Higher mortality of severe influenza patients with probable aspergillosis than those with and without other coinfections

Cited by 78 publications

References 28 publications

Invasive pulmonary aspergillosis and influenza co-infection in immunocompetent hosts: case reports and review of the literature

Invasive pulmonary aspergillosis and influenza co-infection in immunocompetent hosts: case reports and review of the literature

Aspergillosis related to severe influenza: A worldwide phenomenon?

Analysis of risk factors of fungal superinfections in viral pneumonia patients: A systematic review and meta‐analysis

Contact Info

Product

Resources

About