Higher Metabolic Risk with National Institutes of Health Versus Rotterdam Diagnostic Criteria for Polycystic Ovarian Syndrome in Turkish Women

Anaforoğlu, İnan; Algün, Ekrem; Incecayir, Omer; Ersoy, Kerem

doi:10.1089/met.2011.0019

Cited by 32 publications

(30 citation statements)

References 42 publications

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“…Disagreement has persisted regarding whether the two additional phenotypes (oligo-ovulation with PCO or hyperandrogenism with PCOS) in Rotterdam criteria actually do have classical PCOS, because PCO on ultrasound is a very common finding in normal population [20]. Also in some studies they found that using NIH criteria predicts the metabolic risk more appropriately than Rotterdam criteria [21]. …”

Section: Discussionmentioning

confidence: 99%

Epidemiology of polycystic ovary syndrome: a cross sectional study of university students at An-Najah national university-Palestine

Musmar

Afaneh

Mo'alla

2013

Reprod Biol Endocrinol

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BackgroundPolycystic Ovary Syndrome (PCOS) is the most common gynecological endocrinopathy in women of reproductive age. Despite its heavy burden on female reproduction and general health, there is no study regarding PCOS prevalence in Palestine. This study aims to establish prevalence of PCOS among female university students at An-Najah National University-Palestine and to explore its possible risk factors.MethodsA cross sectional study was conducted on 137 female students using convenience sampling method for age group (18–24) years. PCOS cases were identified according to the National Institute of health (NIH) criteria through clinical interview and assessment for participants at the University clinics. Menstrual irregularities regarding cycle and flow were identified and clinical hyperandrogenism was assessed as the self-reported degree of hirsutism using the modified Ferriman Gallwey (mF-G) scoring method of more than 8 score. Biochemical hyperandrogenism for girls with menstrual irregularities was assessed by measuring free testosterone level. Data were analyzed using SPSS version 17 applying descriptive methods; different risk factor relationships were estimated using bivariate analysis and multivariate logistic regression.ResultsThe estimated prevalence of PCOS was 7.3% , acne was the only studied risk factor among others to be statistically significantly related to PCOS patients (OR = 8.430, P-value = 0.015). Clinical Hirsutism was found in 27% of participants, 70% of whom had idiopathic hirsutism.ConclusionsPrevalence of PCOS in Palestine seems to be relatively high but similar to other Mediterranean statistics. We recommend further studies using wider age group and larger sample for all parts of Palestine in order to generalize results.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of polycystic ovary syndrome: a cross sectional study of university students at An-Najah national university-Palestine

Musmar

Afaneh

Mo'alla

2013

Reprod Biol Endocrinol

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“…There is some evidence that metabolic features of PCOS differ across the diagnostic criteria with a higher prevalence of obesity and IR and worsened metabolic features reported for women diagnosed according to the NIH in comparison with the Rotterdam criteria. 41,42 However, this is not consistently demonstrated. A systematic review of adiposity in PCOS on 43 studies using NIH criteria and 63 studies using Rotterdam criteria 37 reported variable and broadly similar prevalence of overweight and obesity (NIH: 20%-100% vs Rotterdam: 5.9%-93.7%), obesity (14.3%-100% vs 12.5%-94.6%) and central obesity (49.3%-85.5% vs 20.0%-66.5%) across the diagnostic categories.…”

Section: Pcos Phenotypes and Adverse Pregnancy Outcomesmentioning

confidence: 92%

Section: Possible Contributing Mechanisms Of Pcos In Adverse Pregnancmentioning

confidence: 99%

“…A systematic review of adiposity in PCOS on 43 studies using NIH criteria and 63 studies using Rotterdam criteria 37 reported variable and broadly similar prevalence of overweight and obesity (NIH: 20%-100% vs Rotterdam: 5.9%-93.7%), obesity (14.3%-100% vs 12.5%-94.6%) and central obesity (49.3%-85.5% vs 20.0%-66.5%) across the diagnostic categories. Worsened cardiometabolic risk in PCOS by NIH is also largely related to elevated total or abdominal adiposity that may be present in this phenotype 41 and IR as assessed by the gold standard euglycaemic hyperinsulinemic clamp is similar between women with PCOS by both Rotterdam and NIH after correction for BMI. 11 This suggests that IR and associated cardiometabolic abnormalities occur independent of adiposity in PCOS, but are worsened by adiposity.…”

Section: Pcos Phenotypes and Adverse Pregnancy Outcomesmentioning

confidence: 99%

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Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice

Khomami

Boyle

Tay

et al. 2018

Clinical Endocrinology

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Summary Although there is a growing body of literature reporting that pregnancies in women with polycystic ovary syndrome (PCOS) are associated with greater complications than those without PCOS, methodological differences across studies make these results difficult to consolidate. This narrative review outlines potential mechanisms involved in adverse pregnancy outcomes in PCOS and the nature of the complications. It covers limitations of current evidence and future research directions. Future research should include prospective studies with phenotypic stratification of PCOS and matching or consideration of specific PCOS manifestations and risk factors specific to each pregnancy complication. This review also emphasizes the importance of following a healthy lifestyle for women with PCOS and of individualized care according to overall risk factors for pregnancy complications.

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“…Participants were excluded if they had contraindications to fMRI, were pregnant within 6 months of the start of the study, had a history of substance abuse, used centrally acting medications or corticosteroids, or if they had used hormones within 2 months of the start of the study. We used the National Institutes of Health (NIH) criteria of menstrual irregularity and hyperandrogenism for the PCOS diagnosis because a higher metabolic risk has been seen with these diagnostic criteria (2, 15). Insulin resistance was defined as a homeostasis model assessment (HOMA2)–Glycemia (mmol/L) × Insulinemia ( μ IU/mL)/22.5–sensitivity of ≤60%.…”

Section: Methodsmentioning

confidence: 99%

Functional neuroimaging of emotional processing in women with polycystic ovary syndrome: a case-control pilot study

Marsh

Berent-Spillson

Love

et al. 2013

Fertility and Sterility

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Objective To evaluate emotional processing in women with insulin-resistant polycystic ovary syndrome (IR-PCOS) and its relationship to glucose regulation and the mu-opioid system. Design Case-control pilot. Setting Tertiary referring medical center. Patient(s) Seven women with IR-PCOS and five non-insulin-resistant controls, aged 21–40 years, recruited from the general population. Intervention(s) Sixteen weeks of metformin (1,500 mg/day) in women with IR-PCOS. Main Outcome Measure(s) Assessment of mood, metabolic function, and neuronal activation during an emotional task using functional magnetic resonance imaging (fMRI), and mu-opioid receptor availability using positive emission tomography (PET). Result(s) We found that insulin-resistant PCOS patients [1] had greater limbic activation during an emotion task than controls (n = 5); [2] trended toward decreased positive affect and increased trait anxiety; [3] after metformin treatment, had limbic activation that no longer differed from controls; and [4] had positive correlations between fMRI limbic activation during emotional processing and mu-opioid binding potential. Conclusion(s) Patients with IR-PCOS had greater regional activation during an emotion task than the controls, although this resolved with metformin therapy. Alterations in mu-opioid neurotransmission may underlie limbic system activity and mood disorders in IR-PCOS. Clinical Trial Registration Number NCT00670800.

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Higher Metabolic Risk with National Institutes of Health Versus Rotterdam Diagnostic Criteria for Polycystic Ovarian Syndrome in Turkish Women

Abstract: The NIH criteria identify women at high risk for insulin resistance and metabolic syndrome. The Rotterdam criteria include women who have less severe metabolic implications.

Cited by 32 publications

References 42 publications

Epidemiology of polycystic ovary syndrome: a cross sectional study of university students at An-Najah national university-Palestine

Epidemiology of polycystic ovary syndrome: a cross sectional study of university students at An-Najah national university-Palestine

Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice

Functional neuroimaging of emotional processing in women with polycystic ovary syndrome: a case-control pilot study

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