Higher levels of serum IL-1β and TNF-α are associated with an increased probability of major depressive disorder

Das, Rajesh; Emon, Md. Prova Zaman; Shahriar, Mohammad; Nahar, Zabun; Islam, Sardar Mohammad Ashraful; Bhuiyan, Mohiuddin Ahmed; Islam, Sheikh Nazrul; Islam, Md. Rabiul

doi:10.1101/2020.10.04.20206508

Cited by 3 publications

(3 citation statements)

References 52 publications

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“…So, people generally do not even care about finding the root cause of such an alarming rate of suicide. Mental health issues like depression, anxiety, loneliness remain undiscovered here (Das et al, 2021b; Repon et al, 2021). Therefore, victims do not realize that social media is causing this harm to them partially.…”

Section: Discussionmentioning

confidence: 99%

Association between the use of social networking sites and mental health of young generation in Bangladesh: A cross‐sectional study

Islam

Jannath

Moona

et al. 2021

Journal Community Psychology

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The social networking sites (SNS) are popular among people of all levels. Here we aimed to evaluate the relationship between the use of SNS and the mental health of the young generation in Bangladesh. We conducted this cross‐sectional study among 791 subjects aged between 15 and 40 years. Self‐reported questionnaires were used to collect demographics and SNS usage patterns of the respondents. We have measured the levels of loneliness, depression, generalized anxiety, and sleep disturbance using the recommended mental health assessment scales. The estimations of loneliness, depression, generalized anxiety, and sleep disturbance among the respondents were 64%, 38%, 63%, and 75%, respectively. Young adults, female sex, unmarried individuals, students, and urban residents reported higher psychological issues regarding the SNS use. Reported mental health issues were associated with time spent in SNS, the number of friends and groups connected with, personal beliefs, and feeling about SNS. A notable association between the use of SNS and the mental health issues of users has been ascertained. The present study findings might have significant implications in the field of clinical psychology and psychotherapy. Therefore, we recommend more comprehensive clinical interventions to find the tangible impact of SNS on the mental health of users.

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Section: Discussionmentioning

confidence: 99%

Association between the use of social networking sites and mental health of young generation in Bangladesh: A cross‐sectional study

Islam

Jannath

Moona

et al. 2021

Journal Community Psychology

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“…Together with our enrichment in several immunologic signatures, our result indicated that MDD with insomnia is associated with a dysfunctional immune system. Accumulating evidence has suggested that MDD is linked to elevated proinflammatory cytokines such as interleukin (IL)-1, IL-6, tumor necrosis factor (TNF)-α, and chemokines [81][82][83][84]. Studies also indicated that the phase shift of IL-6 and TNF secretion is associated with chronic insomnia [85].…”

Section: Discussionmentioning

confidence: 99%

GWAS Meta-Analysis Reveals Shared Genes and Biological Pathways Between Major Depressive Disorder and Insomnia

Lin¹,

Wang²,

Chen³

2021

Preprint

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Major depressive disorder (MDD) is one of the most prevalent and disabling mental disorders worldwide. Among the symptoms of MDD, sleep disturbance such as insomnia is prominent and the first reason patients may seek professional help. However, the underlying pathophysiology of this comorbidity is still elusive. Recently, genome-wide association studies (GWAS) have begun to unveil the genetic background of several psychiatric disorders, including MDD and insomnia. Identifying the shared genomic risk loci between comorbid psychiatric disorders could be a valuable strategy to understand their comorbidity. This study seeks to identify the shared genes and biological pathways between MDD and insomnia based on their shared genetic variants. First, we performed a meta-analysis based on the GWAS summary statistics of MDD and insomnia obtained from Psychiatric Genomics Consortium and UK Biobank, respectively. Next, we associated shared genetic variants to genes using two gene mapping strategies: (a) positional mapping based on genomic proximity and (b) expression quantitative trait loci (eQTL) mapping based on gene expression linkage across multiple tissues. As a result, a total of 719 shared genes were identified. Over half (51%) of them are protein-coding genes. Functional enrichment analysis shows that the most enriched biological pathways are related to epigenetic modification, sensory perception, and immunologic signatures. We also identified druggable targets using a network approach. Together these results may provide insights into understanding the genetic predisposition and underlying biological pathways of comorbid MDD and insomnia symptoms.

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“…Despite having various proposed mechanisms of developing MDD, mounting pieces of evidence have suggested a strong association between chronic inflammatory processes and the pathophysiology of MDD (Miller et al, 2009; Nishuty et al, 2019). Recent findings in neuroscience also indicated an association between the families of immune protein-designated chemokines and many neuroimmune processes related to psychiatric illnesses, for examples, synaptic transmission, and plasticity, hindrance in the progression of neurogenesis, and neuron-glia communication (Das et al, 2020; Heinisch and Kirby, 2009; Pujol et al, 2005; Stuart and Baune, 2014). Activation of the inflammatory response system causes alterations in any of these functions that may lead to the pathogenesis of MDD (Daria et al, 2020; Islam et al, 2018b; Nishuty et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Monocyte chemoattractant protein-1 levels are associated with major depressive disorder

Proma

Daria

Islam

et al. 2020

Preprint

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Major depressive disorder (MDD) is a distressing condition characterized by persistent low mood, loss of interest in daily activities. Many biological, psycho-social, and genetic factors are thought to be involved with depression. The present study aimed to investigate the serum levels of monocyte chemoattractant protein-1 (MCP-1) in MDD patients to explore its role in the development of depression. This case-control study recruited 114 MDD patients and 106 healthy controls (HCs) matched by age and gender. A specialized psychiatrist diagnosed the cases and evaluated the controls based on the diagnostic and statistical manual for mental disorders, 5th edition. The serum MCP-1 levels were quantified by commercially available enzyme-linked immune sorbent assay kits. The Hamilton depression rating scale (Ham-D) was applied to measure the severity of depression. We observed the decreased levels of serum MCP-1 in MDD patients compared to HCs. A significant negative correlation was obtained between serum MCP-1 levels and Ham-D scores. Also, female MDD patients with higher Ham-D scores exhibited lower serum MCP-1 levels. The receiver operating characteristic analysis demonstrated the good diagnostic value of MCP-1 with the area under the curve at 0.837. The depression-related alteration of serum MCP-1 may be more complicated than the current assumption and depends on the characteristics of the individual patients. Our study suggests that the serum MCP-1 levels might be involved in the pathophysiology and mechanism of MDD. The present findings, along with the diagnostic evaluation, might be used to assess the depression risk.

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Higher levels of serum IL-1β and TNF-α are associated with an increased probability of major depressive disorder

Cited by 3 publications

References 52 publications

Association between the use of social networking sites and mental health of young generation in Bangladesh: A cross‐sectional study

Association between the use of social networking sites and mental health of young generation in Bangladesh: A cross‐sectional study

GWAS Meta-Analysis Reveals Shared Genes and Biological Pathways Between Major Depressive Disorder and Insomnia

Monocyte chemoattractant protein-1 levels are associated with major depressive disorder

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