Higher Levels of Psychological Burden and Alterations in Personality Functioning in Crohn’s Disease and Ulcerative Colitis

Engel, Felicitas; Berens, Sabrina; Gauss, Annika; Schaefert, Rainer; Eich, Wolfgang; Tesarz, Jonas

doi:10.3389/fpsyg.2021.671493

Cited by 13 publications

(10 citation statements)

References 56 publications

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“…Previous neuroimaging studies have shown that the FPN is critical for the regulation of emotions. Our rs-FC findings in the FPN could be implicated in the inhibition of mentalization processes recently highlighted in patients with IBD ( Agostini et al, 2019 ; Engel et al, 2021 ). Chronic exposure to physical discomfort in the context of CD has been suggested to lead to reduced mentalization (the ability to understand one’s own behavior and the behavior of others) and result in alterations in brain areas that are involved in emotion processing.…”

Section: Discussionsupporting

confidence: 58%

An examination of resting-state functional connectivity in patients with active Crohn’s disease

Thapaliya,

Eldeghaidy,

Radford

et al. 2023

Front. Neurosci.

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BackgroundAlterations in resting state functional connectivity (rs-FC) in Crohn’s Disease (CD) have been documented in default mode network (DMN) and frontal parietal network (FPN) areas, visual, cerebellar, salience and attention resting-state-networks (RSNs), constituting a CD specific neural phenotype. To date, most studies are in patients in remission, with limited studies in active disease.MethodsTwenty five active CD cases and 25 age-, BMI- and gender-matched healthy controls (HC) were recruited to a resting-state-functional Magnetic Resonance Imaging (rs-fMRI) study. Active disease was defined as C-reactive protein>5 mg/dL, faecal calprotectin>250 μg/g, or through ileocolonoscopy or MRE. rs-fMRI data were analysed using independent component analysis (ICA) and dual regression. Differences in RSNs between HCs and active CD were assessed, and rs-FC was associated with disease duration and abdominal pain.ResultsIncreased connectivity in the FPN (fusiform gyrus, thalamus, caudate, posterior cingulate cortex, postcentral gyrus) and visual RSN (orbital frontal cortex) were observed in CD versus HC. Decreased activity was observed in the salience network (cerebellum, postcentral gyrus), DMN (parahippocampal gyrus, cerebellum), and cerebellar network (occipital fusiform gyrus, cerebellum) in CD versus HCs. Greater abdominal pain scores were associated with lower connectivity in the precuneus (visual network) and parietal operculum (salience network), and higher connectivity in the cerebellum (frontal network). Greater disease duration was associated with greater connectivity in the middle temporal gyrus and planum temporale (visual network).ConclusionAlterations in rs-FC in active CD in RSNs implicated in cognition, attention, emotion, and pain may represent neural correlates of chronic systemic inflammation, abdominal pain, disease duration, and severity.

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Section: Discussionsupporting

confidence: 58%

An examination of resting-state functional connectivity in patients with active Crohn’s disease

Thapaliya,

Eldeghaidy,

Radford

et al. 2023

Front. Neurosci.

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“…Among the included studies, three compared patients suffering from IBS with patients diagnosed with IBD [26][27][28], while other studies focused on patients with one of these conditions (IBS or IBD) and compared them with a control group [29][30][31][32]. RFS mean (SD) scores were 2.7 (1.4) for IBS, 1.4 (1.9) for NAP, and 3.3 (1.7) for AD.…”

Section: Resultsmentioning

confidence: 99%

“…There were differences between IBS-M and IBS-C (p = 0.023). No significant differences between IBS-M and IBS-D, and between IBS-D and IBS-C. With regard to the instruments used to assess mentalization, three studies used the Mentalization Questionnaire (MZQ) [26,28,31], two studies used the Metacognitions Questionnaire-30 (MCQ-30) [27,32], one study used both the Reflective Functioning Questionnaire (RFQ) and Reading the Mind in the Eyes Test (RMET) [29], and one study used both the Brief Reflective Function Interview (BRFI) and Reflective Functioning Scale (RFS) [30].…”

Section: Resultsmentioning

confidence: 99%

Inflammatory Bowel Disease and Irritable Bowel Syndrome: What Differences in Mentalization Abilities? A Scoping Review

Benfante,

Cisarò,

Ribaldone

et al. 2023

IJERPH

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Mentalization is a psychological process that enables individuals to understand the self and others in terms of intentional mental states. The aim of this scoping review was to provide an overview of the findings on mentalization in patients with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). A literature search, in line with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols extension for Scoping Review guidelines, was conducted in the following bibliographic databases: PubMed, PsycINFO, and Scopus. Databases were queried using the following strings (with Boolean operators): (“mentaliz*” OR “metacogniti*” OR “theory of mind” OR “ToM” OR “reflective function*”) AND (“irritable bowel syndrome” OR “IBS” OR “inflammatory bowel disease” OR “IBD”). In line with the eligibility criteria, seven articles were included. Results showed that no significant differences in metacognitive ability were found between patients in the IBD and IBS groups. This review revealed the mentalizing difficulties for patients with IBD and IBS. These results should be interpreted with caution since they are based on a few studies that used different instruments to assess mentalizing processes. Future studies are needed to clarify the role of mentalization in patients with these gastrointestinal conditions.

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“…For instance, psoriasis (PsO) is associated with psychological comorbidities, such as depression ( 3 ). Inflammatory bowel disease (IBD) patients have a higher level of depression and anxiety than healthy controls ( 4 ). Furthermore, autoimmune diseases can cause physical limitations or disabilities in patients with refractory to conventional treatments.…”

Section: Introductionmentioning

confidence: 99%

Research progress of autoimmune diseases based on induced pluripotent stem cells

Ren,

Jiang,

et al. 2024

Front. Immunol.

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Autoimmune diseases can damage specific or multiple organs and tissues, influence the quality of life, and even cause disability and death. A ‘disease in a dish’ can be developed based on patients-derived induced pluripotent stem cells (iPSCs) and iPSCs-derived disease-relevant cell types to provide a platform for pathogenesis research, phenotypical assays, cell therapy, and drug discovery. With rapid progress in molecular biology research methods including genome-sequencing technology, epigenetic analysis, ‘-omics’ analysis and organoid technology, large amount of data represents an opportunity to help in gaining an in-depth understanding of pathological mechanisms and developing novel therapeutic strategies for these diseases. This paper aimed to review the iPSCs-based research on phenotype confirmation, mechanism exploration, drug discovery, and cell therapy for autoimmune diseases, especially multiple sclerosis, inflammatory bowel disease, and type 1 diabetes using iPSCs and iPSCs-derived cells.

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Higher Levels of Psychological Burden and Alterations in Personality Functioning in Crohn’s Disease and Ulcerative Colitis

Cited by 13 publications

References 56 publications

An examination of resting-state functional connectivity in patients with active Crohn’s disease

An examination of resting-state functional connectivity in patients with active Crohn’s disease

Inflammatory Bowel Disease and Irritable Bowel Syndrome: What Differences in Mentalization Abilities? A Scoping Review

Research progress of autoimmune diseases based on induced pluripotent stem cells

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